Mooren's Ulcer following Extracapsular Cataract Extraction

Nr, Acharya; Srinivasan, M; Kundu, Arunava; Tm, Lietman; Jp, Whitcher; Et, Cunningham

doi:10.1177/112067210801800306

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…Corneoscleral incisions, particularly those related to extra capsular cataract extraction, have been specifically implicated in the pathogenesis of MU. A recent study investigating the relationship between MU and prior cataract extraction found that the ulceration in patients with prior extracapsular cataract extraction was typically unilateral, developed within 2 years of the cataract surgery and occurred at or contiguous with the cataract wound, which was typically a superior limbal incision in the majority of cases [12,21].…”

Section: Risk Factorsmentioning

confidence: 98%

Mooren’s ulcer

Zelefsky

Srinivasan

Cunningham

2011

Expert Review of Ophthalmology

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Mooren's ulcer (MU) is an inflammatory peripheral ulcerative keratopathy that occurs most commonly in the developing world. Recent evidence supports the notion that autoimmune mechanisms are involved in the pathogenesis of this disease. Patients with MU typically develop painful, progressive peripheral ulceration of the cornea that, if untreated, can lead to corneal perforation and blindness. Risk factors for the development of MU include HLA-DR17 haplotype expression, prior corneal surgery or trauma, and hookworm infestation. A thorough ocular and systemic history and clinical examination, together with directed laboratory testing, should be carried out to rule out other causes of corneal ulceration, including both infectious keratitis and peripheral ulcerative keratitis secondary to an underlying systemic autoimmune disease. Treatment of MU is often challenging, but typically includes local and/or systemic corticosteroids. Noncorticosteroid immunosuppressive agents, conjunctival resection or advancement and tectonic surgical repair have also been used with success in patients refractory to corticosteroid therapy.

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Section: Risk Factorsmentioning

confidence: 98%

Mooren’s ulcer

Zelefsky

Srinivasan

Cunningham

2011

Expert Review of Ophthalmology

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“…This is supported by the fact that their cases healed after limbal conjunctivectomy. However, Acharya et al, [5] in a retrospective study of patients who had extracapsular cataract extraction in Madurai, India, concluded that exposure of normally concealed antigens may contribute to the pathogenesis of MU in some patients. Zelefsky et al [6] demonstrated an association between MU and human leucocyte antigen (HLA) type DR17(3) in patients from Tamil Nadu state of south India.…”

Section: Introductionmentioning

confidence: 95%