Moraxella catarrhalis, Kingella, and Other Gram-Negative Cocci

MURPHY, TIMOTHY F.

doi:10.1016/b978-0-443-06839-3.00213-7

Cited by 7 publications

(6 citation statements)

References 83 publications

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“…Extrapolation of these data indicate that adults with COPD experience 2 to 4 million exacerbations caused by M. catarrhalis annually in the US [22]. The most recent editions of the major textbooks of Internal Medicine and Infectious Diseases now recognize M. catarrhalis as one of the major causes of exacerbations of COPD [27, 28]. …”

Section: Role Of M Catarrhalis In Copdmentioning

confidence: 99%

Potential impact of a Moraxella catarrhalis vaccine in COPD

Perez

Murphy

2019

Vaccine

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Moraxella catarrhalis is the second most common cause of exacerbations in adults with COPD, resulting in enormous morbidity and mortality in this clinical setting. Vaccine development for M. catarrhalis has lagged behind the other two important causes of exacerbations in COPD, nontypeable Haemophilus influenzae and Streptococcus pneumoniae. While no licensed vaccine is currently available for M. catarrhalis, several promising candidate vaccine antigens have been identified and characterized and are close to entering clinical trials. Key steps that are required to advance vaccines for M. catarrhalis along the translational pipeline include standardization of assay systems to assess candidate antigens, identification of a reliable correlate of protection and expansion of partnerships between industry, academia and government to overcome regulatory hurdles. A vaccine to prevent M. catarrhalis infections in COPD would have a major impact in reducing morbidity, mortality and healthcare costs in COPD.

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Section: Role Of M Catarrhalis In Copdmentioning

confidence: 99%

Potential impact of a Moraxella catarrhalis vaccine in COPD

Perez

Murphy

2019

Vaccine

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“…Commensal Neisseria is a rare cause of invasive diseases such as meningitis, endocarditis, bacteremia, ocular infections, pericarditis, empyema, peritonitis, septic arthritis, bursitis, and osteomyelitis (1). Reports of intraabdominal infection due to Neisseria species are exceedingly rare.…”

Section: Introductionmentioning

confidence: 99%

The First Case Report of Acute Cholangitis and Bacteremia Due to <i>Neisseria subflava</i>

et al. 2017

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We herein report a case of acute cholangitis and bacteremia caused by a commensal Neisseria species, Neisseria subflava, in an 82-year-old man with cholangiocarcinoma. Emergency endoscopic nasobiliary drainage and cefoperazone/sulbactam therapy were effective. Gram negative coccobacilli were isolated from both blood and bile cultures on 5% sheep blood agar. The isolate was identified as N. subflava biovar perflava by mass spectrometry, a sequence analysis of the 16S rRNA, and biochemical testing. Although biliary infections due to commensal Neisseria are extremely rare, this case demonstrates the possibility of its occurrence in patients undergoing bile duct treatment.

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“…Over the past three decades, M. catarrhalis has accounted for 10% of the bacteria mediated exacerbations in patients with chronic obstructive pulmonary disease (COPD). 1,2 Nosocomial respiratory tract infections are also caused by it. 3 The prevalence of betalactamase producing strains is increasing.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Moraxella catarrhalis in patients of lower respiratory tract infection with underlying risk factors

2017

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Background: Moraxella catarrhalis is a Gram-negative diplococcus, commonly found as a normal flora in the human upper respiratory tract. Recently, M. catarrhalis has emerged as an important and common human respiratory tract pathogen. This study was aimed to determine the rate of isolation of M. Catarrhalis in patients attending a tertiary care hospital with lower respiratory tract infection (LRTI), antibiotic susceptibility pattern and predisposing factors responsible for their infection.Methods: A prospective study was carried out in 1001 lower respiratory specimens from patients (above 20 years’ age) with suspected LRTI. The study investigated by microscopic examination, culture and antibiotic sensitivity test according to the standard guidelines. Assessment of clinical significance of M. Catarrhalis was ascertained on the basis of preformed criteria.Results: A total of 60 clinically significant M. Catarrhalis were isolated from the 930 culture positive samples. The isolates showed maximum sensitivity to second and third generation cephalosporins (95%), azithromycin (90%) followed by amoxicillin clavulanic acid (85%). Rate of isolation was more in males (70%) and elderly people above 60 years (63.33%) were found to be more affected. Patients (58.33%) with Chronic Obstructive Pulmonary Diseases (COPD) were found to be more prone to get infection by M. Catarrhalis.Conclusions: Moraxella catarrhalis should be considered as significant lower respiratory tract pathogen especially in elderly patients with underlying risk factors like COPD.

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Moraxella catarrhalis, Kingella, and Other Gram-Negative Cocci

Cited by 7 publications

References 83 publications

Potential impact of a Moraxella catarrhalis vaccine in COPD

Potential impact of a Moraxella catarrhalis vaccine in COPD

The First Case Report of Acute Cholangitis and Bacteremia Due to <i>Neisseria subflava</i>

Prevalence of Moraxella catarrhalis in patients of lower respiratory tract infection with underlying risk factors

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