Morbidity and Discomfort of Ten-Core Biopsy of the Prostate Evaluated by Questionnaire

Abstract

Transition zone biopsies have been found to increase the detection rates of cancer of the prostate in patients with negative digital rectal examination. There are however no data available whether the higher biopsy rate is associated with greater morbidity. The present study was therefore designed to evaluate the complication rate of extended sextant biopsy. In this prospective study, 162 consecutive patients who presented for prostatic evaluation were included. After starting prophylactic antibiotic treatment 48 h prior to the procedure, transrectal ultrasound-guided core biopsies were obtained from each lobe: three each from the peripheral zone (apex, mid-zone and base) and two from the transition zone of each prostatic lobe. In all patients a questionnaire was obtained 10–12 days after the procedure. Major complications occurred in 3 patients. In 2 of the 3 cases major macroscopic hematuria was treated by an indwelling catheter for 1 or 2 days and 1 patient developed fever >38.5°C for 1 day. Minor macroscopic hematuria was present in 68.5% of the patients. In 17.9% of these cases, the hematuria lasted for more than 3 days. Hematospermia was observed in 19.8% and minor rectal bleeding occurred in 4.9%. Ten-core biopsies did not lead to an increase in adverse effects or complications when compared to the results of sextant biopsies reported in the literature.

Comparative study on Periprostatic local anesthesia with Intraprostatic local anesthesia for ultrasonoguided transrectal prostatic biopsy

“…Regarding the complications biopsy procedure the present study showed that rectal bleeding and urinary tract infection were observed 2(6.7%) and 1(3.3%) in group I and group II respectively. The same complication were found in 2% of case in the study in their series 3,19,20,21 . In the current study urinary tract infection was 2(6.7%) in group I and 1(3.3%) in in group II.…”

“…This difference was significant (p<0.05). Including the degree of pain after 30 minutes of biopsy and duration of pain, were not significantly (p>0.05) different between the two groups 19,20 . The results obtained in above authors is strongly support the present study, where the pain degree during biopsy it was found that most patients had mild pain in group I which was 13(50.0%) and in group II no pain was predominant which was 13(43.3%) of the patients.…”

Bleeding after transrectal ultrasonography‐guided prostate biopsy: a study of 7‐day morbidity after a six‐, eight‐ and 12‐core biopsy protocol

“…Modern prostate biopsy with the appropriate antibiotic prophylaxis has an acceptable safety margin, but mild haematuria, haematospermia and rectal bleeding are common. Table 3 summarizes the previous publications on the complication rates after prostate biopsy, classified according to the number of cores taken [3,6,7,10–27].…”

Severe Life Threatening Rectal Bleed After Prostate Biopsy Requiring Angiographic Therapy: A Case Report

“…After this procedure, mild rectal bleeding may occur in 0-25% of patients [2, 3]. Other complications include self limiting hematuria, hematospermia and urinary tract infection, most of which resolve with conservative therapy [4, 5].…”