Morbidity and mortality of elderly patients with zoonotic Salmonella and Campylobacter: A population-based study

Gradel, Kim Oren; Schønheyder, Henrik Carl; Dethlefsen, Claus; Kristensen, Brian; Ejlertsen, Tove; Nielsen, Henrik

doi:10.1016/j.jinf.2008.06.013

Cited by 17 publications

(11 citation statements)

References 35 publications

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“…Studies from developed countries have shown that the elderly with NTS infections have higher hospitalization and mortality rates. 23,24 As opposed to reports of increasing resistance to traditional first-line agents in both Asia and Africa and increasing rates of multidrug resistance, 13 we found a marked decrease in MDR and decreasing resistance to the traditional first-line agents ampicillin, chloramphenicol, and TMP/SMX but an increasing resistance to ciprofloxacin. This result may be because of a decreasing use of non-fluoroquinolone agents in favor of fluoroquinolones for the treatment of both gastroenteritis and undefined febrile illnesses.…”

Section: Discussioncontrasting

confidence: 96%

Non-Typhoidal Salmonella Gastroenteritis at a Diarrheal Hospital in Dhaka, Bangladesh, 1996–2011

Leung¹,

Das²,

Malek³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Abstract. Data on non-typhoidal Salmonella (NTS) infection in South Asia are limited. We used data gathered prospectively from 1996 to 2011 as part of a hospital surveillance system in Dhaka, Bangladesh, to identify diarrheal patients with NTS isolated from stool. NTS was isolated in 1.3% (468 of 37,439) of diarrheal patients; 47% of total cases of NTS were in children 5 years of age, although older adults ( 60 years) had the highest isolation rates. NTS isolation peaked in the monsoon months of July and August. Over the study period, rates of multidrug resistance decreased, whereas rates of decreased susceptibility to ciprofloxacin increased. Compared with control patients, NTS patients were older and wealthier; however, no differences in type of housing or exposure to animals were found. NTS patients had increased inflammatory cells in stool and required more fluid resuscitation.

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Section: Discussioncontrasting

confidence: 96%

Non-Typhoidal Salmonella Gastroenteritis at a Diarrheal Hospital in Dhaka, Bangladesh, 1996–2011

Leung¹,

Das²,

Malek³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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“…Increased prevalence of comorbid diseases have been observed in elderly persons [6,28]. However, the spectrum of underlying diseases was different from the young comparators in our study.…”

Section: Discussioncontrasting

confidence: 78%

“…In the USA, 22 % of patients with Salmonella infections required hospitalization, while the hospitalization rate in the elderly (>60 years) with NTS infection was even higher [5]. In a populationbased study performed in Denmark, Gradel et al found that the incidence rate of NTS bacteraemia increased steadily from age groups 40-49 years to >90 years [6]. Not surprisingly, elderly patients with Salmonella infection had a higher mortality rate than children and young adults, because of multiple comorbidity [5,7,8].…”

Section: Introductionmentioning

confidence: 99%

Non-typhoidal Salmonella bacteraemia in elderly patients: an increased risk for endovascular infections, osteomyelitis and mortality

Chen

Lee

et al. 2012

Epidemiol. Infect.

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Non-typhoidal Salmonella (NTS) is a common pathogen causing foodborne infections, bacteraemia, and extra-intestinal focal infections (EFIs) in humans. The study compares the clinical characteristics of elderly patients with NTS bacteraemia with those of young adults. Of 272 adults with NTS bacteraemia identified in this study, 162 (59·6%) were aged ⩾55 years. EFIs were observed in 36% of the 162 patients. The most common EFIs in the elderly patients (⩾55 years) was mycotic aneurysm, followed by pulmonary infections and bone/joint infections. Elderly patients more often had chronic heart, lung, renal and malignant diseases, had more EFIs, and a higher 30-day mortality rate. Independent factors of 30-day mortality in elderly patients were solid-organ tumour [adjusted odds ratio (aOR) 4·4, P=0·003], mycotic aneurysm (aOR 3·7, P=0·023) and shock (aOR 12·1, P<0·0001). HIV infection, autoimmune diseases, and receipt of immunosuppressive therapy were more often observed in young patients.

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“…Studies of older persons infected with Campylobacter sp. show increased hospitalization and mortality, with clinical care further complicated by higher levels of comorbidities and risk for invasive infection [8, 31]. However, whether such a shift in the age structure of campylobacteriosis across high-income countries can be generalized is less certain, with a recent US study showing a decreasing rate of campylobacteriosis with increasing age [8].…”

Section: Discussionmentioning

confidence: 99%

The campylobacteriosis conundrum – examining the incidence of infection withCampylobactersp. in Australia, 1998–2013

et al. 2016

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Campylobacter sp. are a globally significant cause of gastroenteritis. Although rates of infection in Australia are among the highest in the industrialized world, studies describing campylobacteriosis incidence in Australia are lacking. Using national disease notification data between 1998 and 2013 we examined Campylobacter infections by gender, age group, season and state and territory. Negative binomial regression was used to estimate incidence rate ratios (IRRs), including trends by age group over time, with post-estimation commands used to obtain adjusted incidence rates. The incidence rate for males was significantly higher than for females [IRR 1·20, 95% confidence interval (CI) 1·18-1·21], while a distinct seasonality was demonstrated with higher rates in both spring (IRR 1·18, 95% CI 1·16-1·20) and summer (IRR 1·17, 95% CI 1·16-1·19). Examination of trends in age-specific incidence over time showed declines in incidence in those aged <40 years combined with contemporaneous increases in older age groups, notably those aged 70-79 years (IRR 1998-2013: 1·75, 95% CI 1·63-1·88). While crude rates continue to be highest in children, our findings suggest the age structure for campylobacteriosis in Australia is changing, carrying significant public health implications for older Australians.

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Morbidity and mortality of elderly patients with zoonotic Salmonella and Campylobacter: A population-based study

Cited by 17 publications

References 35 publications

Non-Typhoidal Salmonella Gastroenteritis at a Diarrheal Hospital in Dhaka, Bangladesh, 1996–2011

Non-Typhoidal Salmonella Gastroenteritis at a Diarrheal Hospital in Dhaka, Bangladesh, 1996–2011

Non-typhoidal Salmonella bacteraemia in elderly patients: an increased risk for endovascular infections, osteomyelitis and mortality

The campylobacteriosis conundrum – examining the incidence of infection withCampylobactersp. in Australia, 1998–2013

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