Morbidity associated with the use of foramen ovale electrodes

Pastor, Jesús; Sola, Rafael G.; Hernando‐Requejo, Virgilio; Navarrete, E. García; Pulido, Paloma Contreras

doi:10.1111/j.1528-1167.2007.01314.x

Cited by 35 publications

(24 citation statements)

References 15 publications

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“…Here, we validate a minimally invasive method to detect this activity using FO electrodes, which are safe, readily inserted percutaneously, and allow highly sensitive monitoring of mTL activity. 9,14,15 The clinical utility of FO recordings in evaluating dementia patients is not yet known, though our FO recordings clearly demonstrate that scalp EEG findings greatly underestimate subcortical hyperexcitability in AD (Figure 2). All mTL seizures and over 95% of mTL spikes were not evident on scalp EEG.…”

mentioning

confidence: 86%

Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease

Lam

Deck

Goldman

et al. 2017

Nat Med

310

271

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We directly assessed mesial temporal activity in two Alzheimer’s disease (AD) patients without a history or EEG evidence of seizures, using intracranial foramen ovale electrodes. We detected clinically silent hippocampal seizures and epileptiform spikes during sleep, a period when both were most likely to interfere with memory consolidation. These index cases support a model in which early development of occult hippocampal hyperexcitability may contribute to the pathogenesis of AD.

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mentioning

confidence: 86%

Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease

Lam

Deck

Goldman

et al. 2017

Nat Med

310

271

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“…Briefly, all patients were studied with scalp electroencephalography (EEG), interictal single photon emission computer tomography (SPECT) with 99m Tc-HmPAO, magnetic resonance imaging (MRI) 1.5 T, and video-electroencephalography (v-EEG) using 19 scalp electrodes according to the international 10–20 system. In some patients, six-contact platinum foramen ovale electrodes (FO), with 1 cm center-to-center spacing (AD-Tech, Racine, USA), were inserted bilaterally under general anesthesia, as previously published [25]. During the operation, resection was guided by electrocorticography (ECoG) placing a 4 × 5 electrode grid (lateral neocortex) and a 1 × 8 electrode strip (uncus and parahippocampal gyrus) directly over the cortex.…”

Section: Methodsmentioning

confidence: 99%

Plasma Albumin Induces Cytosolic Calcium Oscilations and DNA Synthesis in Human Cultured Astrocytes

Vega-Zelaya

Ortega

Sola

et al. 2014

BioMed Research International

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So far, a little is known about transition from normal to focal epileptic brain, although disruption in blood-brain barrier and albumin had recently involved. The main objective of this work is to characterize the response of cultured human astrocytes to plasma albumin, including induction of DNA synthesis. Cortical tissue was obtained from 9 patients operated from temporal lobe epilepsy. Astrocytes were cultured for 3-4 weeks and cytosolic calcium concentration ([Ca2+]c) was measured. Bovine and human plasma albumin were used. We observed that low albumin concentration decreases [Ca2+]c, while higher concentration, induces increase in [Ca2+]c. It was shown that increase in [Ca2+]c was mediated by inositol 1,4,5-trisphosphate and released from internal stores. Increase in [Ca2+]c was reduced to 19% by blocking the transforming growth factor-beta (TGF-βR) receptor. Albumin induces DNA synthesis in a dose-response manner. Finally, induction of DNA synthesis can be partially blocked by heparin and block of TGF-β; however, the combination of both incompletely inhibits DNA synthesis. Therefore, results suggest that mechanisms other than Ca2+ signals and TGF-β receptor activation might induce DNA synthesis in a lesser degree. These results may be important to further understand the mechanisms involved in the transition from normal to focal epileptic brain.

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“…Sola restarted the ESU in the University Hospital de La Princesa, Madrid. This is probably the Spanish ESU that has developed the highest activity and had the largest number of scientific publications in the last years [73, 83, 86, 87]. …”

Section: Resultsmentioning

confidence: 99%

The start and development of epilepsy surgery in Europe: a historical review

et al. 2015

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Epilepsy has not always been considered a brain disease, but was believed to be a demonic possession in the past. Therefore, trepanation was done not only for medical but also for religious or spiritual reasons, originating in the Neolithic period (3000 BC). The earliest documentation of trepanation for epilepsy is found in the writings of the Hippocratic Corpus and consisted mainly of just skull surgery. The transition from skull surgery to brain surgery took place in the middle of the nineteenth century when the insight of epilepsy as a cortical disorder of the brain emerged. This led to the start of modern epilepsy surgery. The pioneer countries in which epilepsy surgery was performed in Europe were the UK, Germany, and The Netherlands. Neurosurgical forerunners like Sir Victor Horsley, William Macewen, Fedor Krause, and Otfrid Foerster started with “modern” epilepsy surgery. Initially, epilepsy surgery was mainly done with the purpose to resect traumatic lesions or large surface tumours. In the course of the twentieth century, this changed to highly specialized microscopic navigation-guided surgery to resect lesional and non-lesional epileptogenic cortex. The development of epilepsy surgery in Southern Europe, which has not been described until now, will be elaborated in this manuscript. To summarize, in this paper, we provide (1) a detailed description of the evolution of European epilepsy surgery with special emphasis on the pioneer countries; (2) novel, never published information about the development of epilepsy surgery in Southern Europe; and (3) we review the historical dichotomy of invasive electrode implantation strategy (Anglo-Saxon surface electrodes versus French-Italian stereoencephalography (SEEG) model).

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Morbidity associated with the use of foramen ovale electrodes

Cited by 35 publications

References 15 publications

Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease

Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease

Plasma Albumin Induces Cytosolic Calcium Oscilations and DNA Synthesis in Human Cultured Astrocytes

The start and development of epilepsy surgery in Europe: a historical review

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