Morbilliform rash after administration of Pfizer-BioNTech COVID-19 mRNA vaccine

Jedlowski, Patrick; Jedlowski, Mahdieh F.

doi:10.5070/d3271052044

Cited by 53 publications

(34 citation statements)

References 4 publications

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“…Recurrence occurred in 16% of those who experienced the first reaction. Exanthema reactions can be easily treated with systemic and/or topical corticosteroid and systemic antihistamines to relieve symptoms and shorten the disease duration [20,21]. We also observed the occurrence of uncommon rashes as SDRIFE (Figure 4).…”

Section: Exanthemasmentioning

confidence: 66%

“…Exanthemas (morbilliform or maculopapular, varicella-like, or papulovesicular); vascular lesions (purpura/petechiae, livedoid, and chilblain-like); and urticarial are morphological patterns that are already associated with SARS-CoV-2 infection [79]. Hence, common immunopathological mechanisms, including host immune activation against viral particles, rather than direct viral damage, may be involved [6,7,21]. Polyethylene glycol-2000 (PEG) and polysorbate 80 are the two main potential allergenic/immunogenic excipients in the COVID-19 vaccines.…”

Section: Discussionmentioning

confidence: 99%

“…Pruritus may be severe. A purpuric hue can be found, especially when the rash involves the inferior limbs [18][19][20][21][22][23]. A -papulovesicular or varicelliform rash is characterized by small papules/vesicles surrounded by erythema without a herpetiform arrangement [6].…”

Section: Exanthemasmentioning

confidence: 99%

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Cutaneous Adverse Reactions Associated with SARS-CoV-2 Vaccines

Bellinato

Maurelli

Gisondi

et al. 2021

JCM

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Many patients are receiving SARS-CoV-2 vaccinations, which have been associated with a variety of adverse effects. Cutaneous adverse reactions to SARS-CoV-2 vaccinations have been progressively reported, but they have not been reviewed according to their morphological clinical patterns. The objective of this review was to summarize the existing data concerning the cutaneous adverse reactions following SARS-CoV-2 vaccines and group them according to common morphological and pathogenetic patterns. We reviewed the English language literature up to 15 August 2021, using predefined keywords to identify the relevant studies evaluating cutaneous adverse reactions associated with SARS-CoV-2 vaccines. We search for recurrent morphological patterns sharing clinical signs and symptoms and physio-pathological mechanisms. Timing to onset following the first or booster dose of the vaccine, predisposing conditions, therapeutic management, and outcome were also collected. Among the dermatological manifestations associated with SARS-CoV-2 vaccinations, we distinguished: (1) new onset reactions and (2) flares of preexisting dermatoses. The most common were injection site reactions, affecting 30–70% and generally mild or moderate. Small case series or single case reports included filler reactions, exanthemas, vascular lesions, urticaria, eczematous dermatitis, autoimmune bullous reactions, and severe cutaneous adverse reactions. In addition, the exacerbation of chronic immuno-mediated dermatoses (mainly psoriasis and atopic dermatitis) and reactivations of herpes infection were reported. The cutaneous reactions were generally mild, self-limiting, and resembled common cutaneous drug eruptions and/or COVID-19 skin manifestations.

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Section: Exanthemasmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

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Cutaneous Adverse Reactions Associated with SARS-CoV-2 Vaccines

Bellinato

Maurelli

Gisondi

et al. 2021

JCM

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“…However, polymorphic exanthemas in connection with viral infections, drugs, or both may be specified as rash if a further description is added (e.g., morbilliform-"like an exanthema seen with measles"). Normally, paraviral exanthemas and maculopapular drug eruptions develop within one week, and are self-limiting; the same seems to be true for rashes associated with COVID-19 vaccines, assuming a correct diagnosis in the published data [21,55]. On the other hand, there are reports about very early onset of rashes-within hours-which then persist as pruritic eruptions over weeks [56].…”

Section: Maculopapular Morbilliform and Vesicular Rashmentioning

confidence: 94%

Cutaneous Adverse Reactions to COVID-19 Vaccines: Insights from an Immuno-Dermatological Perspective

et al. 2021

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(1) Background: Numerous vaccines are under preclinical and clinical development for prevention of severe course and lethal outcome of coronavirus disease 2019 (COVID-19). In light of high efficacy rates and satisfactory safety profiles, some agents have already reached approval and are now distributed worldwide, with varying availability. Real-world data on cutaneous adverse drug reactions (ADRs) remain limited. (2) Methods: We performed a literature research concerning cutaneous ADRs to different COVID-19 vaccines, and incorporated our own experiences. (3) Results: Injection site reactions are the most frequent side effects arising from all vaccine types. Moreover, delayed cutaneous ADRs may occur after several days, either as a primary manifestation or as a flare of a pre-existing inflammatory dermatosis. Cutaneous ADRs may be divided according to their cytokine profile, based on the preponderance of specific T-cell subsets (i.e., Th1, Th2, Th17/22, Tregs). Specific cutaneous ADRs mimic immunogenic reactions to the natural infection with SARS-CoV-2, which is associated with an abundance of type I interferons. (4) Conclusions: Further studies are required in order to determine the best suitable vaccine type for individual groups of patients, including patients suffering from chronic inflammatory dermatoses.

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“…Since December 2020, different types of COVID-19 vaccines have been developed to limit the spread of the pandemic [Jedlowski et al, 2021]. There are few reported side effects and adverse reactions of COVID-19 vaccines.…”

mentioning

confidence: 99%