More on the Inhibition of the Urease Reaction by Boric Acid

What transcriptomics and proteomics can tell us about a high borate perturbed boron tolerant Bacilli strain

“…60 Borate can also disrupt protein function via two distinct reversible mechanisms. 61 The first replicates a high energy transition state structure by creating a covalent boronic acid tetrahedral adduct with the active site serine oxygen. 62 The second technique is the development of a stable transition-state analogue and the inhibition of metalloenzymes by binding to metal ions in their active sites.…”