2016
DOI: 10.1016/j.eururo.2016.03.052
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More Than 15 Years of Experience with Intradetrusor OnabotulinumtoxinA Injections for Treating Refractory Neurogenic Detrusor Overactivity: Lessons to Be Learned

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Cited by 42 publications
(40 citation statements)
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“…Eighteen studies involving 1533 patients were included in the review and their characteristics are shown in Table 1. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] The level of evidence of the included studies ranged from 3 to 4. Ten studies were retrospective case series, [12][13][14][15][16][17][18][19]22,27 seven studies were prospective cohort studies 11,20,21,23,24,26,28 and the remaining article was a mixed study comprising both retrospective and prospective components.…”
Section: Study and Patient Characteristicsmentioning
confidence: 99%
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“…Eighteen studies involving 1533 patients were included in the review and their characteristics are shown in Table 1. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] The level of evidence of the included studies ranged from 3 to 4. Ten studies were retrospective case series, [12][13][14][15][16][17][18][19]22,27 seven studies were prospective cohort studies 11,20,21,23,24,26,28 and the remaining article was a mixed study comprising both retrospective and prospective components.…”
Section: Study and Patient Characteristicsmentioning
confidence: 99%
“…Ten studies were retrospective case series, [12][13][14][15][16][17][18][19]22,27 seven studies were prospective cohort studies 11,20,21,23,24,26,28 and the remaining article was a mixed study comprising both retrospective and prospective components. 25 Thirteen studies used Botox, 12,15,[17][18][19][20][21][23][24][25][26][27][28] four studies used Dysport, 13,14,16,22 and one study used both Botox and Dysport. 11 Botox was administered at doses of 200 or 300 U, and Dysport was administered at doses ranging from 500 to 1000 U.…”
Section: Study and Patient Characteristicsmentioning
confidence: 99%
See 1 more Smart Citation
“…38,39 Furthermore, in the longest follow-up study of the use of onabotulinumtoxinA (15 years), the overall discontinuation rate amongst all neurogenic patients (SCI, MS, MMC) was 40%, and only 14% of MS patients continued with the treatment. 40 …”
Section: Disease Specific Findingsmentioning
confidence: 99%
“…Vanilloids are contraindicated in case of ureteral reflux, bladder mucosa lesions, coagulation impairment, pregnancy, and breastfeeding. 29 discontinue treatment over time due to a lack of clinical and/or urodynamic efficacy or switch to another treatment, 39 so that alternative treatment options are urgently needed. Indeed, vanilloids might become a promising therapeutic alternative but not in its current form because of the unfavorable safety profile.…”
Section: Implications For Practicementioning
confidence: 99%