More Than Just a Periodontal Pathogen –the Research Progress on Fusobacterium nucleatum

Chen, Yuanxin; Huang, Zhijie; Tang, Zhengming; Huang, Yi‐Sheng; Huang, Mingshu; Liu, Hongyu; Ziebolz, Dirk; Schmalz, Gerhard; Jia, Bo; Zhao, Jianjiang

doi:10.3389/fcimb.2022.815318

Cited by 47 publications

(48 citation statements)

References 166 publications

(182 reference statements)

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“…to the host tissue or that Fusobacterium spp. facilitated the co-adhesion of other bacteria, as reported for F. nucleatum in periodontal diseases 39 50 . F. nucleatum has tissue-adhesive and co-aggregating properties qua its virulence factors FadA Fap2, RadD, and FomA 39–42 .…”

Section: Discussionsupporting

confidence: 59%

Biofilms and core pathogens shape the tumour microenvironment and immune phenotype in colorectal cancer

Kvich,

Fritz,

Zschach

et al. 2023

Preprint

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Objective: Increasing evidence links bacterial dysbiosis with colorectal cancer (CRC) carcinogenesis, with enrichment of core pathogens such as Bacteroides fragilis and Fusobacterium nucleatum. Here, we characterized the in situ biogeography and the molecular interplay between bacteria and the host at the transcriptional level in mucosal colon biopsies. Design: The influence of CRC core pathogens and biofilms on the tumour microenvironment (TME) was investigated in biopsies from patients with and without CRC (paired normal tissue and healthy tissue biopsies) using fluorescence in situ hybridization and dual-RNA sequencing. Results: Distinct, tissue-invasive, mixed-species biofilms characterized CRC tissue with B. fragilis and F. nucleatum enrichment, especially in right-sided tumours. Notably, Fusobacterium spp. was associated with increased bacterial biomass and inflammatory response in CRC samples. CRC samples with high bacterial activity had increased expression of proinflammatory cytokines, defensins, matrix-metalloproteases, and immunomodulatory factors, contrasting with samples with low bacterial activity with an expression profile resembling those of healthy tissue samples. Moreover, immune cell profiling showed that B. fragilis and F. nucleatum were essential modulators of the TME and correlated with the infiltration of neutrophils and CD4+ T-cells. Overall, bacterial activity was critical for the immune phenotype and correlated with the infiltration of various immune cell subtypes, including M2 macrophages and regulatory T-cells, highlighting the importance of widening the scope beyond CRC core pathogens. Conclusion: Biofilms and core pathogens shape the TME and immune phenotype in CRC. Our results support that Fusobacterium spp. may provide a therapeutic target to reduce biofilms and the inflammatory response in the TME.

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Section: Discussionsupporting

confidence: 59%

Biofilms and core pathogens shape the tumour microenvironment and immune phenotype in colorectal cancer

Kvich,

Fritz,

Zschach

et al. 2023

Preprint

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“…Thus, it can promote and accelerate the development of periodontitis. Moreover, Fusobacterium nucleatum can cause local halitosis and pulp infections and may systemically promote the development or progression of oral cancer and other extraoral diseases [ 62 ]. Kang et al [ 63 ] explored and identified three types of Weissella cibaria from human saliva, which produce hydrogen peroxides.…”

Section: Oral Microbiome In Periodontal Diseasesmentioning

confidence: 99%

“…Suzuki et al [ 64 ] showed that Lactobacillus saliva WB21 buccal tablets can specifically reduce the amount of F. nucleatum in patients with halitosis. This means that the use of W. cibaria and Lactobacillus saliva WB21 as probiotics can be a beneficial method of combating bad breath and controlling PD [ 62 , 64 ].…”

Section: Oral Microbiome In Periodontal Diseasesmentioning

confidence: 99%

The Role of the Oral Microbiome in the Development of Diseases

Kozak

Pawlik

2023

IJMS

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Periodontal disease (PD) is a complex and infectious illness that begins with a disruption of bacterial homeostasis. This disease induces a host inflammatory response, leading to damage of the soft and connective tooth-supporting tissues. Moreover, in advanced cases, it can contribute to tooth loss. The aetiological factors of PDs have been widely researched, but the pathogenesis of PD has still not been totally clarified. There are a number of factors that have an effect on the aetiology and pathogenesis of PD. It is purported that microbiological, genetic susceptibility and lifestyle can determine the development and severity of the disease. The human body’s defence response to the accumulation of plaque and its enzymes is known to be a major factor for PD. The oral cavity is colonised by a characteristic and complex microbiota that grows as diverse biofilms on all mucosal and dental surfaces. The aim of this review was to provide the latest updates in the literature regarding still-existing problems with PD and to highlight the role of the oral microbiome in periodontal health and disease. Better awareness and knowledge of the causes of dysbiosis, environmental risk factors and periodontal therapy can reduce the growing worldwide prevalence of PDs. The promotion of good oral hygiene, limiting smoking, alcohol consumption and exposure to stress and comprehensive treatment to decrease the pathogenicity of oral biofilm can help reduce PD as well as other diseases. Evidence linking disorders of the oral microbiome to various systemic diseases has increased the understanding of the importance of the oral microbiome in regulating many processes in the human body and, thus, its impact on the development of many diseases.

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“…The overlap of the unique members of oral microbes with other remote organs is consistent with previous clinical studies in which Fusobacterium nucleatum , a Gram-negative oral anaerobe, were clinically suspected to be a major risk factor in colorectal cancer [ 97 , 98 , 99 ], oral squamous cell carcinoma (OSCC) [ 100 ], and in preterm and term stillbirth [ 101 , 102 ]. Likewise, an infamous oral pathogenic bacterium, Porphyromonas gingivalis , is related to pancreatic cancer [ 103 ], colorectal cancer [ 104 , 105 , 106 ], liver health [ 107 ], rheumatoid arthritis [ 108 , 109 ], diabetes [ 110 , 111 , 112 ], OSCC [ 113 , 114 ], and neurodegenerative diseases [ 88 , 89 , 90 , 91 , 92 , 115 , 116 , 117 , 118 ]. In the case of atherosclerotic CVD, when the vascular tissues of the coronary and femoral arteries of the patients with CVD were examined, P. gingivalis was found in 42 out of 42 patients [ 119 ].…”

Section: Oral Pathogens and Systemic Diseasesmentioning

confidence: 99%

Leaky Gum: The Revisited Origin of Systemic Diseases

Park¹,

Park²,

Lee³

et al. 2022

Cells

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The oral cavity is the gateway for microorganisms into your body where they disseminate not only to the directly connected respiratory and digestive tracts but also to the many remote organs. Oral microbiota, travelling to the end of the intestine and circulating in our bodies through blood vessels, not only affect a gut microbiome profile but also lead to many systemic diseases. By gathering information accumulated from the era of focal infection theory to the age of revolution in microbiome research, we propose a pivotal role of “leaky gum”, as an analogy of “leaky gut”, to underscore the importance of the oral cavity in systemic health. The oral cavity has unique structures, the gingival sulcus (GS) and the junctional epithelium (JE) below the GS, which are rarely found anywhere else in our body. The JE is attached to the tooth enamel and cementum by hemidesmosome (HD), which is structurally weaker than desmosome and is, thus, vulnerable to microbial infiltration. In the GS, microbial biofilms can build up for life, unlike the biofilms on the skin and intestinal mucosa that fall off by the natural process. Thus, we emphasize that the GS and the JE are the weakest leaky point for microbes to invade the human body, making the leaky gum just as important as, or even more important than, the leaky gut.

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More Than Just a Periodontal Pathogen –the Research Progress on Fusobacterium nucleatum

Cited by 47 publications

References 166 publications

Biofilms and core pathogens shape the tumour microenvironment and immune phenotype in colorectal cancer

Biofilms and core pathogens shape the tumour microenvironment and immune phenotype in colorectal cancer

The Role of the Oral Microbiome in the Development of Diseases

Leaky Gum: The Revisited Origin of Systemic Diseases

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