Morinda citrifolia fruit reduces stress-induced impairment of cognitive function accompanied by vasculature improvement in mice

Muto, Junko; Lee, Hosung; Uwaya, Akemi; Isami, Fumiyuki; Ohno, Makoto; Mikami, Toshio

doi:10.1016/j.physbeh.2010.04.014

Cited by 34 publications

(25 citation statements)

References 29 publications

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“…Likewise, in another report, an ethyl acetate extract of noni fruit prevented beta-amyloid (25–35)-induced cognitive dysfunction in mice [23]. In addition, administration of noni fruit juice protected brains from stress-induced impairment of cognitive function [24]. Given these results, it seems unlikely that the observed attenuation of ethanol CPP by TNJ in the current study can be accounted for by drug-induced memory impairment.…”

Section: Discussionsupporting

confidence: 72%

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Noni (<i>Morinda citrifolia</i> Linn.) fruit juice attenuates the rewarding effect of ethanol in conditioned place preference in mice

Pandy

Khan

2016

Exp. Anim.

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Morinda citrifolia L. commonly known as noni or Indian mulberry belongs to the family Rubiaceae. Noni fruit juice has recently become a very popular remedy for the treatment of several diseases, including psychiatric disorders. This study aimed to investigate the anticraving effect of Tahitian Noni® Juice (TNJ) against ethanol seeking behavior in ICR male mice using the conditioned place preference (CPP) test. The CPP procedure consisted of four phases: preconditioning, conditioning, extinction, and reinstatement. During conditioning, intraperitoneal (i.p.) injections of ethanol (2 g/kg body weight (bw)) and normal saline (10 ml/kg bw) were given on alternate days for 12 days. Then, the animals were subjected to extinction trials for the next 12 days to weaken CPP. Finally, CPP was reinstated in the extinguished animals by a single low-dose priming injection of ethanol (0.4 g/kg bw, i.p.). The effect of TNJ (as a source of drinking water) on different phases of ethanol CPP in mice was studied. TNJ-treated mice showed a significant reduction in ethanol seeking behavior in the CPP test. The reference drug, acamprosate (ACAM) also showed a similar effect in the CPP test. The outcome of this study suggests that TNJ is effective in attenuating ethanol craving in mice and could be utilized for the treatment of alcohol dependence. Further clinical studies in this direction are warranted to support the present preclinical findings.

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Section: Discussionsupporting

confidence: 72%

“…These results confirmed the safety of noni juice in subacute treatment for 30 days. Recently, noni juice has been reported to have nootropic activity in stress-induced cognitively impaired mice using the Morris water maze (MWM) test [24]. …”

Section: Discussionmentioning

confidence: 99%

Noni (<i>Morinda citrifolia</i> Linn.) fruit juice attenuates the rewarding effect of ethanol in conditioned place preference in mice

Pandy

Khan

2016

Exp. Anim.

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“…14 The discoveries by Muto et al recommended that the association of Noni fruit juice shields brain from stress-instigated impedance of psychological capacity and that this defensive impact might be identified with change in stressinitiated diminishes in vein thickness in the hippocampal dentate gyrus. 15 Harada et al recommended that Noni juice could encourage insulin discharge after ischemic stress and may reduce the advancement of glucose intolerance. These components may add to the neuronal defensive impact of Noni juice against ischemic stress.…”

Section: Introductionmentioning

confidence: 99%

In vitro & ex vivo Acetylcholinesterase Inhibitory Activity of Morinda citrifolia Linn (Noni) Fruit Extract

Jeyabalan¹,

Subramanian²,

Cheekala³

et al. 2017

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Background: Psychological problem is a key medical issue for numerous neuropsychiatric and neurodegenerative diseases, for example, schizophrenia, Alzheimer's, dementia, seizure and Parkinsonism. Morinda citrifolia (Noni) has been utilized for a considerable length of time to cure or counteract assortment of diseases by conventional therapeutic professionals in Hawaii and Polynesia. Objective: The present study is focused to identify the neuroprotective activity of Morinda citrifolia fruit extract (MCFE) on in vitro and ex vivo animal model by inhibition of acetylcholinesterase (AChE), an enzyme target used for the treatment of Alzheimer's disease. Methods: Acetylcholinesterase inhibition assay was performed by in vitro & ex vivo methods as described by Ellman et al. In vitro antioxidant assay of the extract was performed by DPPH free radical scavenging activity & nitric oxide scavenging activity. Statistical analysis used: Statistical analysis was carried out using non linear regression analysis for plotting the line of best fit for the observed values using GraphPad Prism software. Results: By performing in vitro antioxidant assay the IC 50 value of the standard quercetin was found to be 46.22 µg/ml as compared to the MCFE which has an IC 50 value of 43.14 µg/ml for DPPH free radical scavenging activity. Similarly the IC 50 value of the standard ascorbic acid was found to be 81.85 µg/ml as compared to the MCFE which has an IC 50 value of 148.0 µg/ml for nitric oxide scavenging activity. Acetylcholinesterase inhibition assay was performed by in vitro method and the IC 50 value of MCFE and neostigmine was found to be 31.84 µg/ml & 19.71 µg/ml respectively. Conclusions: The present study investigated the neuroprotective activity of MCFE and it was identified by both in vitro and ex vivo techniques that the phytoconstituents has the ability to improve the learning and memory function by inhibiting the acetylcholinesterase. Key words:Morinda citrifolia, Noni, Acetylcholinesterase, Neuroprotective activity, in vitro, ex vivo. Key Messages: The present study investigated the neuroprotective activity of Morinda citrifolia and it was identified by both in vitro and ex vivo techniques that the phytoconstituents in the plant can improve the learning and memory function by inhibiting the acetylcholinesterase. Further the antioxidant potential of the plant was also evident from the DPPH and nitric oxide scavenging activity. Future studies may be designed for chronic administration of Morinda citrifolia to further investigate the effect on in vivo experimentation and also to identify the safety and efficacy parameters at both preclinical and clinical stages.

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“…They suggested that Noni juice protect brain from stress-induced impairment of cognitive function and reported this protective effect may be related to improvement in stress-induced decrease in blood vessel density in the hippocampal dentate gyrus. 57 …”

Section: Effect On Cognitive Functionmentioning

confidence: 99%

Health Benefits of Morinda citrifolia (Noni): A Review

Ali¹,

Kenganora²,

Manjula³

2016

Phcogj

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Background: Morinda citrifolia (Noni) has been used widely as a comple mentary and alternative therapy in many countries owing to its potent anti oxidant activity and proven health benefits. Traditionally, it finds used as a therapeutic remedy to various diseases as an antibacterial, antitumor, anthelminthic, analgesic, anti inflammatory, immunostimulant. Also it has proved beneficial in conditions like gastritis, skin diseases, respiratory infections, menstrual and urinary tract disorders, fever, diabetes and venereal diseases. Objective: This review emphasizes on the phytochemical and mineral profile of the different parts of Noni plant. In addition, this review corroborates the pharmacological basis for the various health benefits, traditional and medicinal applications of Noni. Materials and Methods: All the available information of Noni were collected from electronic databases such as Academic Journals, Ethnobotany, Ethnopharmacology, Springer, PubMed, Google Scholar, Science Direct and other primary and secondary sources. Results: According to our search results pertaining to scientific literature, Morinda citrifolia is used for more than 40 types of ailments worldwide. Crude extract of various parts of plant and fruit juice are reported

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Morinda citrifolia fruit reduces stress-induced impairment of cognitive function accompanied by vasculature improvement in mice

Cited by 34 publications

References 29 publications

Noni (<i>Morinda citrifolia</i> Linn.) fruit juice attenuates the rewarding effect of ethanol in conditioned place preference in mice

Noni (<i>Morinda citrifolia</i> Linn.) fruit juice attenuates the rewarding effect of ethanol in conditioned place preference in mice

In vitro & ex vivo Acetylcholinesterase Inhibitory Activity of Morinda citrifolia Linn (Noni) Fruit Extract

Health Benefits of Morinda citrifolia (Noni): A Review

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