2023
DOI: 10.1186/s12974-023-02715-y
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Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy

Abstract: Objective Patients with hypertension have a risk of depression. Morinda officinalis oligosaccharides (MOOs) have anti-depressant properties. In this study, we aimed to determine whether MOOs can improve the symptoms of depression in individuals with hypertension. Methods Dahl salt-sensitive rats fed with a high-salt diet were stimulated by chronic unpredictable mild stress to mimic hypertension with depression. Primary astrocytes and neurons were i… Show more

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Cited by 29 publications
(10 citation statements)
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“… 37 , 48 Former research indicated that diseases induced by LPS in rat models are linked to abnormalities in hemodynamic parameters. 49 , 50 It has been documented that after treatment with LPS in rats, the HR and HWI are augmented, while LVEF and MAP are lessened, 37 , 38 which was consistent with our findings. We also confirmed that Dioscin reversed the effects of LPS on HR, HWI, LVEF, and MAP in SIC rats.…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“… 37 , 48 Former research indicated that diseases induced by LPS in rat models are linked to abnormalities in hemodynamic parameters. 49 , 50 It has been documented that after treatment with LPS in rats, the HR and HWI are augmented, while LVEF and MAP are lessened, 37 , 38 which was consistent with our findings. We also confirmed that Dioscin reversed the effects of LPS on HR, HWI, LVEF, and MAP in SIC rats.…”
Section: Discussionsupporting
confidence: 92%
“…LPS, a major component of the outer membrane of Gram‐negative bacteria, is frequently used to induce SIC in rats as an important immunomodulator 37,48 . Former research indicated that diseases induced by LPS in rat models are linked to abnormalities in hemodynamic parameters 49,50 . It has been documented that after treatment with LPS in rats, the HR and HWI are augmented, while LVEF and MAP are lessened, 37,38 which was consistent with our findings.…”
Section: Discussionsupporting
confidence: 90%
“…Previous study showed that M. officinalis oligosaccharides can regulate mitochondrial autophagy in astrocytes. 21 Our results identified the inhibitory effect of another extract from M. officinalis How. on RANKL-induced OCP autophagy.…”
Section: Discussionmentioning
confidence: 59%
“…Inflammation and mitochondrial dysfunction are also associated with the pathogenesis of depression ( Bansal and Kuhad, 2016 ; Kohler et al, 2016 ). In addition, Morinda Officinalis Oligosaccharide Capsule mitigate depression by regulating Mitofusin two protein-mediated mitophagy in rats ( Yang et al, 2023 ). Morinda Officinalis Oligosaccharide Capsule mainly contains inulin-type oligosaccharides extracted from the roots of M. officinalis, which is effective in ameliorating symptoms of depressive disorder ( Zhang et al, 2018 ).…”
Section: Discussionmentioning
confidence: 99%