Moringa isothiocyanate-1 inhibits LPS-induced inflammation in mouse myoblasts and skeletal muscle

Sailaja, Badi Sri; Hassan, Sohaib; Cohen, Evan N.; Tmenova, Irina; Farias-Pereira, Renalison; Verzi, Michael P.; Raskin, Ilya

doi:10.1371/journal.pone.0279370

Cited by 9 publications

(4 citation statements)

References 42 publications

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“…Moringine-specific benzyl ITC from Moringa Oleifera modulated the Nrf2/AER pathway, proinflammatory biomarkers, and apoptotic pathway in different mouse and rat models (Galuppo et al, 2014. In another mouse model (LPS induced), it was found that ITCs effectively decreased TNF-α, IL-1β, IL-6 and inhibited NF-kβ (Sailaja et al, 2022). It also downregulated senescence as it promoted neuronal repair in in vitro Aβ induce SH5Y5Y cells (Silvestro et al, 2021).…”

Section: Bioavailability Of Glcs and Itcsmentioning

confidence: 99%

Advances in Discoveries of Plant Phytochemicals

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Bioavailability Of Glcs and Itcsmentioning

confidence: 99%

Advances in Discoveries of Plant Phytochemicals

2024

Frontiers Research Topics

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“…Moringine-specific benzyl ITC from Moringa Oleifera modulated the Nrf2/AER pathway, proinflammatory biomarkers, and apoptotic pathway in different mouse and rat models ( Galuppo et al, 2014 , ( Galuppo et al, 2015 ). In another mouse model (LPS induced), it was found that ITCs effectively decreased TNF-α, IL-1β, IL-6 and inhibited NF-kβ ( Sailaja et al, 2022 ). It also downregulated senescence as it promoted neuronal repair in in vitro Aβ induce SH5Y5Y cells ( Silvestro et al, 2021 ).…”

Section: Role In Neuroprotection Ache Inhibition and Neuroinflammator...mentioning

confidence: 99%

Dietary glucosinolates derived isothiocyanates: chemical properties, metabolism and their potential in prevention of Alzheimer’s disease

et al. 2023

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Alzheimer’s disease (AD) is the most prevalent form of dementia affecting millions of people worldwide. It is a progressive, irreversible, and incurable neurodegenerative disorder that disrupts the synaptic communication between millions of neurons, resulting in neuronal death and functional loss due to the abnormal accumulation of two naturally occurring proteins, amyloid β (Aβ) and tau. According to the 2018 World Alzheimer’s Report, there is no single case of an Alzheimer’s survivor; even 1 in 3 people die from Alzheimer’s disease, and it is a growing epidemic across the globe fruits and vegetables rich in glucosinolates (GLCs), the precursors of isothiocyanates (ITCs), have long been known for their pharmacological properties and recently attracted increased interest for the possible prevention and treatment of neurodegenerative diseases. Epidemiological evidence from systematic research findings and clinical trials suggests that nutritional and functional dietary isothiocyanates interfere with the molecular cascades of Alzheimer’s disease pathogenesis and prevent neurons from functional loss. The aim of this review is to explore the role of glucosinolates derived isothiocyanates in various molecular mechanisms involved in the progression of Alzheimer’s disease and their potential in the prevention and treatment of Alzheimer’s disease. It also covers the chemical diversity of isothiocyanates and their detailed mechanisms of action as reported by various in vitro and in vivo studies. Further clinical studies are necessary to evaluate their pharmacokinetic parameters and effectiveness in humans.

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“…2 Mouse skeletal myoblasts are cells that rely on anchorage, necessitating the provision of a solid substrate for the creation of cell-based meat. 3 These solid substrates, also known as cell culture scaffolds, play a crucial role in the development of cell-based meat. 4 An optimal scaffold for cell-based meat should be biocompatible, possess a suitable microstructure, offer sufficient mechanical strength, and most importantly, facilitate cell adhesion and sustain metabolic functions.…”

Section: Introductionmentioning

confidence: 99%

Cell-Based Meat Scaffold Based on a 3D-Printed Starch-Based Gel

Wang,

Dai,

Xiang

et al. 2024

J. Agric. Food Chem.

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Starch was mixed with a gel to produce a starch-based gel ink, which exhibited favorable printing characteristics. Through the optimization of infill density, 3D-printed scaffolds with 50% infill density and a highly ordered microstructure were successfully fabricated. The addition of calcium carbonate nanoparticles–glucono delta lactone (CaCO3 NPs-GDL) had notable effects on the swelling degree, in vitro digestion, water stability, and pore distribution of the scaffolds. When the amount of CaCO3 NPs in the starch-based gel was 0.075 g, the resulting 3D-printed gel scaffold with a 50% infill density proved to be the most suitable for cultivating cell-based meat. It featured pore sizes ranging from 80 to 120 μm and a compression modulus of 246.76 Pa. After 7 days of proliferation, the C2C12 mouse skeletal myoblasts exhibited an approximately 2.81-fold increase in cell numbers. The fusion index and maturation index of C2C12 cells on the scaffolds were 57.00 ± 0.45% and 34.56 ± 0.56%, respectively. The starch-based gel scaffolds demonstrated excellent water stability and in vitro degradability. Moreover, C2C12 cells exhibited successful proliferation and differentiation on the starch-based scaffolds, ultimately leading to the production of cell-based meat. This study developed a starch-based composite gel scaffold for the manufacture of cell-based meat.

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Moringa isothiocyanate-1 inhibits LPS-induced inflammation in mouse myoblasts and skeletal muscle

Cited by 9 publications

References 42 publications

Advances in Discoveries of Plant Phytochemicals

Advances in Discoveries of Plant Phytochemicals

Dietary glucosinolates derived isothiocyanates: chemical properties, metabolism and their potential in prevention of Alzheimer’s disease

Cell-Based Meat Scaffold Based on a 3D-Printed Starch-Based Gel

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