“…This is despite the ready availability of UDPglucose as a cofactor in hepatocytes. Although there are relatively few examples of drugs that are glucosidated to any significant extent in mammals, some of them include: morphine, phenobarbital, amobarbital, ibuprofen, and varenicline (Kalow et al, 1979;Arima & Kato, 1990;Bernus et al, 1994;Nandi & Soine, 1997;Chau et al, 2014). In most instances, the same drugs are also metabolized by glucuronidation with higher efficiency, although a few exceptions have been identified, including acyl glucosidation of panoprofen in mice (Arima & Kato, 1990), and N-glucosidation of amobarbital and phenobarbital in humans (Kalow et al, 1979;Bernus et al, 1994;Nandi & Soine, 1997).…”