Morphine‐isoflurane interaction in dogs, swine and Rhesus monkeys

Steffey, Eugene; Baggot, J. D.; Eisele, John H.; Willits, Neil H.; Woliner, M. J.; Jarvis, K. A.; Elliott, A. R.; Tagawa, Masahiro

doi:10.1111/j.1365-2885.1994.tb00234.x

Cited by 102 publications

(112 citation statements)

References 43 publications

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“…A estabilidade cardiorrespiratória determinada pelos AINES ou pela Arnica montana se dá em função da ausência de depressão central, constituindo uma das vantagens do uso pré-operatório desses medicamentos (PIBAROT et al, 1997;FERNANDEZ et al, 2002), quando comparado ao uso de opioides, sobretudo os agonistas totais, que podem causar depressão cardiovascular e respiratória, principalmente quando associados aos anestésicos gerais (STEFFEY et al, 1994).…”

Section: Mathews 2007) Já O Efeito Antiinflamatório Daunclassified

Analgesia e ação antiinflamatória da Arnica montana 12CH comparativamente ao cetoprofeno em cães

et al. 2011

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Section: Mathews 2007) Já O Efeito Antiinflamatório Daunclassified

Analgesia e ação antiinflamatória da Arnica montana 12CH comparativamente ao cetoprofeno em cães

et al. 2011

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“…Morphine and buprenorphine are opioids that are often used in research involving pigs. Furthermore, these opioids have been reported to decrease minimum alveolar concentration (MAC) of the volatile anaesthetic when given preoperatively in many species (Valverde et al 1989, Steffey et al 1994, Doherty et al 2002. For instance, epidural morphine has been reported to reduce MAC of halothane in dogs (Valverde et al 1989), ponies (Doherty et al 1997) and the requirement of isoflurane in pigs (Malavasi et al 2006).…”

mentioning

confidence: 99%

Changes in minimal alveolar concentration of isoflurane following treatment with medetomidine and tiletamine/zolazepam, epidural morphine or systemic buprenorphine in pigs

et al. 2008

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SummaryThe aim of this study was to determine the changes in minimal alveolar concentration (MAC) of isoflurane after treatment with medetomidine and tiletamine/zolazepam (MTZ), epidural morphine or systemic buprenorphine in 11 healthy crossbred pigs. The first part of this study was to measure the baseline values in pigs induced with isoflurane (5%) by face mask and maintained with isoflurane in air and oxygen for 2 h (ISO). Baseline isoflurane MAC was determined using mechanical stimulation. Thereafter, each pig was randomly chosen for a crossover test in which the same animal received three different treatments with at least one week in between treatments. The three treatments were as follows: induction of anaesthesia with medetomidine (0.05 mg kg 21) and tiletamine/zolazepam (2.5 mg kg 21 each) given intramuscularly (MTZ); MTZ followed by epidural morphine (0.1 mg kg 21 ; MTZ/M); and MTZ followed by intramuscular buprenorphine (0.1 mg kg 21; MTZ/B). All pigs were maintained with isoflurane in oxygen and air for 2 h and their lungs were mechanically ventilated. The end-tidal isoflurane concentration, respiratory rate, inspiratory and expiratory O 2 and CO 2 concentrations, heart rate (HR) and arterial blood pressure were recorded every 10 min. Arterial blood gases were analysed every 20 min. Among the treatment groups, differences in isoflurane MAC were tested using GLM and Tukey's method for further comparison; P , 0.05 was adopted as significant. Isoflurane MAC was 1.9 + 0.3%. MTZ reduced isoflurane MAC to 0.6 + 0.1%. Additional morphine or buprenorphine reduced the MTZ isoflurane MAC further to 0.4 + 0.2 and 0.3 + 0.1%, respectively. During MTZ, MTZ/M and MTZ/B mean arterial blood pressure was higher and the alveolar-arterial oxygen tension difference was lower compared with ISO. In conclusion, induction of anaesthesia with MTZ reduced the isoflurane MAC in pigs by 68%. Additional epidural morphine or systemic buprenorphine decreased MTZ isoflurane MAC by 33 and 50%, respectively.

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“…The results of these same studies (MURPHY;HUG, 1982;STEFFEY et al, 1994;WAGNER et al, 2002) suggest that a reduction in the inhalant anesthetic requirements should improve cardiopulmonary function, thereby improving the safety of general anesthesia. The IV combination of morphine and lidocaine or morphine and ketamine has been found to be synergistic and to prevent CNS hypersensitivity when administered to humans with inflammatory or neuropathic pain (WU et al, 2002).…”

Section: Discussionmentioning

confidence: 80%

“…Intravenous administration of morphine can induce mild respiratory depression that is responsive to naloxone (STEFFEY et al, 1994). We could not assess the effects on ventilation because our sheep were mechanically ventilated.…”

Section: Discussionmentioning

confidence: 99%

Effects of the morphine-lidocaine-ketamine combination on cardiopulmonary function and isoflurane sparing in sheep

Beier

Rosa

Oleskovicz³

et al. 2014

Sem. Ci. Agr.

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The aims of this study were to evaluate the isoflurane sparing and clinical effects of a constant rate infusion of morphine -lidocaine -ketamine (MLK) in healthy sheep undergoing experimental gastrointestinal surgery. Twelve adult female sheep (Texel breed) were used, weighing 36.5 ± 8.1 kg. The sheep were anesthetized for the implantation of duodenal cannulas. The sheep were premedicated with 0.3 mg kg -1 intramuscular (IM) morphine and 20 µg kg -1 intravenous (IV) detomidine. After premedication, anesthesia was induced using 5 mg kg -1 ketamine and 0.5 mg kg -1 diazepam IV and maintained using isoflurane in 100% oxygen. After the induction of anesthesia, the animals were allocated into two groups (each n=6); the GMLK (MLK group -10 mg morphine, 150 mg lidocaine, 30 mg de ketamine were added in 500 mL saline) received a 10 mL kg -1 h -1 MLK infusion during the maintenance of anesthesia, and GCON (control group) received 10 mL kg -1 h -1 of 0.9% sodium chloride. The animals were mechanically ventilated. Cardiopulmonary variables and end-tidal isoflurane concentration (FE´Iso) were measured at baseline (immediately before the surgery) and 15, 30 and 45 minutes after initiation of surgery. In GMLK, there was a decrease in the FE´Iso at 15, 30 and 45 minutes, a reduction of up to 75.6% during the surgery. The HR was lower in GMLK compared with GCON at 30 minutes, and the MAP was at during baseline in GCON compared with GMLK. The standing time was less in GMLK than in GCON. The use of intravenous MLK was demonstrated to offer great efficiency as part of a balanced anesthesia protocol in sheep, with a 75.6% reduction in the need for isoflurane, providing stability of the cardiovascular parameters and blood gases with a shortened recovery period. Key words: Sheep, morphine, lidocaine, ketamine, isoflurane ResumoOs objetivos deste estudo foram avaliar a redução na concentração expirada de isoflurano, bem como os efeitos clínicos de uma infusão constante de morfina -lidocaína -cetamina (MLK) em ovinos saudáveis submetidos a cirurgia gastrointestinal experimental. Foram utilizados doze ovinos adultos da raça Texel, fêmeas, pesando 36,5 ± 8,1 kg. Os animais foram anestesiados para implantação de cânulas no duodeno, sendo pré-medicados com morfina 0,3 mg kg -1 , pela via intramuscular (IM), e detomidina 20 ug kg -1 pela via intravenosa (IV). Após a pré-medicação, a anestesia foi induzida com cetamina 5 mg kg -1 e diazepam 0,5 mg kg -1 IV, sendo mantidos com isoflurano em oxigênio a 100%. Após a indução da anestesia os animais foram divididos em dois grupos (n = 6): GMLK (grupo MLK -10 mg de morfina, 150 mg de lidocaína e 30 mg de cetamina foram adicionados em 500 ml de solução salina) que recebeu infusão contínua de MLK na taxa de 10 mL kg

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Morphine‐isoflurane interaction in dogs, swine and Rhesus monkeys

Cited by 102 publications

References 43 publications

Analgesia e ação antiinflamatória da Arnica montana 12CH comparativamente ao cetoprofeno em cães

Analgesia e ação antiinflamatória da Arnica montana 12CH comparativamente ao cetoprofeno em cães

Changes in minimal alveolar concentration of isoflurane following treatment with medetomidine and tiletamine/zolazepam, epidural morphine or systemic buprenorphine in pigs

Effects of the morphine-lidocaine-ketamine combination on cardiopulmonary function and isoflurane sparing in sheep

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