Morphophonemics includes two studies in the fields of morphology and phonology. Morphophonemic studies, especially with regional languages as objects, are still difficult to find and rarely carried out. The purpose of this study is to describe various kinds of phoneme changes and morphophonemic processes in Malay in Tungkal Ilir District. The method used is descriptive analysis with data collection techniques: listen, engage, speak, record and take notes. The research data is in the form of sentences containing morphophonemic words originating from native Malay speakers in Tungkal Ilir District. Based on the results of the study, obtained 66 morphophonemic words found in community speech in Malay in Tungkal Ilir District. Based on these data, found 5 kinds of phoneme changes, namely 5 phoneme appearances, 24 phoneme disappearances, 35 phoneme decay, 2 phoneme changes and 10 phoneme shifts. Based on these results, it can be concluded that the Malay language in Tungkal Ilir District is a regional language that indirectly occurs in the morphophonemic process in the community's language. Morphophonemics is also a study that can be implied in learning at school or college. The study of morphophonemics bequeaths learning resources for learning morphology and phonology at the university or school level in learning local languages.