Morphofunctional changes in the adrenal glands of juvenile rats systematically exposed to hypergravity

Мороз, Г А; Kriventsov, Maxim A.; Кутя, С А

doi:10.15275/rusomj.2018.0401

Cited by 6 publications

(5 citation statements)

References 2 publications

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“…In similar case the adrenal gland can compensate for testis function by producing another font of testosterone. At the present we don't have any evidence concerning a direct effect of hypergravity on other endocrine glands, however, the scienti c literature reports following hypergravity exposure, the alteration of the adrenal gland zona reticularis representing the secondary font of production of testosterone (Moroz et al, 2018). Following these evidence hypergravity seems to decrease widely the testosterone production, and the hypothesis of a wider involvement of hormonal balance may be advanced.…”

Section: Discussionmentioning

confidence: 62%

The Importance of Gravity Vector on Adult Mammalian Organisms: Effects of Hyper-Gravity on Mouse Testis

Bonetto¹,

Magnelli²,

Sabbatini³

et al. 2022

Preprint

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In the time of space explorations, the effect of hyper-gravity on the human physiology is a topic relatively neglected. Nevertheless, astronauts have several experiences of hyper-gravity during their mission. The main disturbance of altered gravity can be imputed to cell cytoskeleton alteration and physiologic homeostasis of the body. Testis has been revealed to be an organ particularly sensible, to be affected by environmental alteration and physiological disturbance. This makes testis an organ eligible for investigating the alteration following exposure to altered gravity. In our study, mice were exposed to hypergravity (3g for 14 days) in Large Diameter Centrifuge. We have observed morphological alteration of the regular architecture of the seminiferous tubules of testis as well as an altered expression of factors involved in junctional complexes of Sertoli cells, responsible to assure the morpho-functional integrity of the organ. The expression of key receptors in the physiological performance, such as Androgen Receptors and Interstitial Cells Stimulating Hormone (ICSH) receptors have been found lower expressed. All these findings indicate the occurrence of altered physiological performance of the organ such as the reduction of the spermatozoa number and an altered relationships with the endocrine physiology following hypergravity exposure.

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Section: Discussionmentioning

confidence: 62%

The Importance of Gravity Vector on Adult Mammalian Organisms: Effects of Hyper-Gravity on Mouse Testis

Bonetto¹,

Magnelli²,

Sabbatini³

et al. 2022

Preprint

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“…The results recorded by Moroz et al 12 who calculated in young adult (70 day old) male rats the ratios of medulla/gland area (12.6%), cortex/gland area (87.4%) and within cortex ZG/cortex area (9.17%) are in total agreement with the measurements of the present study (13.9, 86.1 and 10.8% respectively), whereas their results for ZF/cortex area 69.01% and ZR/cortex area 21.82% differ slightly from ours (49.75 and 39.5% respectively).…”

Section: Discussionmentioning

confidence: 87%

“…In literature, a number of studies exist about their morphometric parameters in mice [1][2][3][4] and rats. [5][6][7][8][9][10][11][12][13][14][15] To our knowledge though, there are no studies comparing morphometric parameters between the two species.…”

Section: Introductionmentioning

confidence: 99%

Adrenal glands of mice and rats: A comparative morphometric study

et al. 2021

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Mice and rats are among the most used laboratory animals. They share numerous similarities along with differences, some yet unexplored. One of them is the morphometry of their adrenal glands, whose characteristics may be related to differences in energy management, immune response, drug metabolism, behaviour and temperament. The present study tries to fill this knowledge gap with the evaluation and comparison of adrenal gland anatomical/morphometric parameters of mice and rats. In groups of 10 ( n = 10) adult, male and female BALB/c mice and Wistar rats, one in every 20 sections transverse to the longitudinal axis of the gland was used for measuring entire gland area, capsule, entire cortex, cortex zones and medulla with the aid of an image analysis system and subjected to statistical analysis. Quotients of the individual areas were calculated and comparison between the resulting ratios was performed. Gland length and volume were also calculated. Statistically significant differences were revealed between the rat female and male cortex area, rat and mouse medulla/cortex, medulla/gland, zona glomerulosa/cortex and cortex/gland ratios, male and female rats’ medulla/cortex, medulla/gland, capsule/gland, zona glomerulosa/cortex, zona reticularis/cortex and zona glomerulosa/zona fasciculata ratios, length and volume. The correlation evaluation revealed that in male rats and in female mice the larger medulla area was accompanied by a larger cortex area and vice versa. In general, a larger cortex area was accompanied by larger areas of cortex zones. The collected data and the revealed differences can possibly contribute to the understanding of the physiology of the two species.

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“…In such case the adrenal gland can compensate for testis function by producing another font of testosterone. At the present we have any evidence concerning a direct effect of hypergravity on other endocrine glands, however, the scientific literature reports following hypergravity exposure, the alteration of the adrenal gland zona reticularis representing the secondary font of production of testosterone [ 24 ]. Following these evidence hypergravity seems to decrease widely the testosterone production, and the hypothesis of a wider involvement of hormonal balance may be advanced.…”

Section: Discussionmentioning

confidence: 99%

The importance of gravity vector on adult mammalian organisms: Effects of hypergravity on mouse testis

Bonetto,

Magnelli,

Sabbatini

et al. 2023

PLoS ONE

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In the age of space exploration, the effect of hypergravity on human physiology is a relatively neglected topic. However, astronauts have several experiences of hypergravity during their missions. The main disturbance of altered gravity can be imputed to cell cytoskeleton alteration and physiologic homeostasis of the body. Testis has proved to be a particularly sensible organ, subject to environmental alteration and physiological disturbance. This makes testis an organ eligible for investigating the alteration following exposure to altered gravity. In our study, mice were exposed to hypergravity (3g for 14 days) in the Large Diameter Centrifuge machine (ESA, Netherland). We have observed a morphological alteration of the regular architecture of the seminiferous tubules of testis as well as an altered expression of factors involved in the junctional complexes of Sertoli cells, responsible for ensuring the morpho-functional integrity of the organ. The expression of key receptors in physiological performance, such as Androgen Receptors and Interstitial Cells Stimulating Hormone receptors, was found lower expressed. All these findings indicate the occurrence of altered physiological organ performance such as the reduction of the spermatozoa number and altered endocrine parameters following hypergravity exposure.

show abstract

Morphofunctional changes in the adrenal glands of juvenile rats systematically exposed to hypergravity

Cited by 6 publications

References 2 publications

The Importance of Gravity Vector on Adult Mammalian Organisms: Effects of Hyper-Gravity on Mouse Testis

The Importance of Gravity Vector on Adult Mammalian Organisms: Effects of Hyper-Gravity on Mouse Testis

Adrenal glands of mice and rats: A comparative morphometric study

The importance of gravity vector on adult mammalian organisms: Effects of hypergravity on mouse testis

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