Morphogenesis of a Cytomegalovirus from an American Bison Affected with Malignant Catarrhal Fever

Todd, William J.; Storz, J.

doi:10.1099/0022-1317-64-5-1025

Cited by 48 publications

(29 citation statements)

References 7 publications

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“…Indeed, it has been shown that BoHV-4 is able to replicate in a broad range of host species both in vivo and in vitro. In addition to cattle, isolates of BoHV-4 have been recovered from other ruminant species (7)(8)(9)(10). Sporadic isolations were also reported in lions, cats, and owl monkeys (Aotus trivirgatus; refs.…”

Section: Introductionmentioning

confidence: 99%

Bovine Herpesvirus 4 Induces Apoptosis of Human Carcinoma Cell Lines In vitro and In vivo

Gillet

Dewals

Farnir³

et al. 2005

Cancer Research

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The idea of using oncolytic viruses for the treatment of cancers was proposed a century ago. During the last two decades, viruses able to replicate specifically in cancer cells and to induce their lysis were identified and were genetically modified to improve their viro-oncolytic properties. More recently, a new approach consisting of inducing selective apoptosis in cancer cells through viral infection has been proposed; this approach has been called viro-oncoapoptosis. In the present study, we report the property of bovine herpesvirus-4 (BoHV-4) to induce, in vitro and in vivo, apoptosis of some human carcinomas. This conclusion relies on the following observations:

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Section: Introductionmentioning

confidence: 99%

Bovine Herpesvirus 4 Induces Apoptosis of Human Carcinoma Cell Lines In vitro and In vivo

Gillet

Dewals

Farnir³

et al. 2005

Cancer Research

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“…Isolates of BoHV-4 have also been recovered from other ruminant species such as American bison (Bison bison) (32), African buffalo (Syncerus caffer) (26), and sheep (36). Sporadic isolations were reported in lions, cats (9), and owl monkeys (Aotus trivirgatus) (1).…”

mentioning

confidence: 99%

The Core 2 β-1,6- N -Acetylglucosaminyltransferase-Mucin Encoded by Bovine Herpesvirus 4 Was Acquired from an Ancestor of the African Buffalo

Markine-Goriaynoff

Georgin

Goltz

et al. 2003

J Virol

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The Bo17 gene of bovine herpesvirus 4 (BoHV-4) is the only viral gene known to date that encodes a homologue of the cellular core 2 ␤-1,6-N-acetylglucosaminyltransferase-mucin type (C2GnT-M). To investigate the origin and evolution of the Bo17 gene, we analyzed its distribution among BoHV-4 strains and determined the sequences of Bo17 from nine representative strains and of the C2GnT-M gene from six species of ruminants expected to encompass the group within which the gene acquisition occurred. Of 34 strains of BoHV-4, isolated from four different continents, all were found to contain the Bo17 gene. Phylogenetic analyses indicated that Bo17 was acquired from a recent ancestor of the African buffalo, implying that cattle subsequently acquired BoHV-4 by cross-species transmission. The rate of synonymous nucleotide substitution in Bo17 was estimated at 5 ؋ 10 ؊8 to 6 ؋ 10 ؊8 substitutions/site/year, consistent with previous estimates made under the assumption that herpesviruses have cospeciated with their hosts. The Bo17 gene acquisition was dated to around 1.5 million years ago. Bo17 sequences from BoHV-4 strains from African buffalo and from cattle formed two separate clades, estimated to have split about 700,000 years ago. Analysis of the ratio of nonsynonymous to synonymous nucleotide substitutions revealed a burst of amino acid replacements subsequent to the transfer of the cellular gene to the viral genome, followed by a return to a strong constraint on nonsynonymous changes during the divergence of contemporary BoHV-4 strains. The Bo17 gene represents the most recent of the known herpesvirus gene acquisitions and provides the best opportunity for learning more about this important process of viral evolution.

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“…1,2 The PCR test has been successfully applied to detect OHV2 DNA in peripheral blood leukocytes 1 and in tissues from terminal cases of SA-MCF in bison 24 and cattle. 4 Previous investigations of SA-MCF resulted in the detection of a cell-associated cytomegalovirus, 30 and retroviruses. 12,27 In the present study, cases of SA-MCF in cattle and bison were analyzed retrospectively for OHV2 and for other persistent bovine herpesviruses, retroviruses, and pestivirus.…”

mentioning

confidence: 99%

Malignant Catarrhal Fever: Polymerase Chain Reaction Survey for Ovine Herpesvirus 2 and Other Persistent Herpesvirus and Retrovirus Infections of Dairy Cattle and Bison

et al. 2000

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Morphogenesis of a Cytomegalovirus from an American Bison Affected with Malignant Catarrhal Fever

Cited by 48 publications

References 7 publications

Bovine Herpesvirus 4 Induces Apoptosis of Human Carcinoma Cell Lines In vitro and In vivo

Bovine Herpesvirus 4 Induces Apoptosis of Human Carcinoma Cell Lines In vitro and In vivo

The Core 2 β-1,6- N -Acetylglucosaminyltransferase-Mucin Encoded by Bovine Herpesvirus 4 Was Acquired from an Ancestor of the African Buffalo

Malignant Catarrhal Fever: Polymerase Chain Reaction Survey for Ovine Herpesvirus 2 and Other Persistent Herpesvirus and Retrovirus Infections of Dairy Cattle and Bison

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