Morphogenesis of intrahepatic bile ducts of the human fetus

Koga, Akitoshi

doi:10.1007/bf00521108

Cited by 61 publications

(21 citation statements)

References 15 publications

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“…21), developed at the junction between the portal sinus and hepatic parenchyma. This process of development was called the ductal plates (Koga, 1971;Ruebner, 1990;Shiojiri, 1984;Van Eyken, 1988a,b).…”

Section: Stage 20mentioning

confidence: 98%

“…At the junction between parenchyma and periportal connective tissue, the tips of hepatic ducts were continuous with hepatic trabeculae and were differentiated into ductal cells. This process of differentiation had progressively continued into the connective tissue of the TPS following its right and left branches (Koga, 1971;O'Rahilly and Muller, 1987). The hepatic veins were discernible and deprived of connective tissue.…”

Section: Stage 17mentioning

confidence: 98%

“…In man, morphological studies of the liver developmental staging were achieved in the specimens of the Carnegie Institution Collection from stages 11 to 23 by Streeter (1942Streeter ( , 1945Streeter ( , 1948Streeter ( , 1951, by O'Rahilly (1978O'Rahilly ( , 1981O'Rahilly ( , 1987O'Rahilly ( , 1992, and by Hutchins and Moore (1988) and from stages 11 to 17 by Severn (1971Severn ( , 1972. Moreover, some reports have dealt with the morphogenesis of bile ducts with special emphasis on ductal plates (Bloom, 1926;Koga, 1971;Ruebner et al, 1990;Shiojiri, 1984).…”

Section: Introductionmentioning

confidence: 99%

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Liver development in the rat and in man during the embryonic period (Carnegie stages 11-23)

Godlewski¹,

Gaubert-Cristol

Rouy

et al. 1997

Microsc. Res. Tech.

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Section: Stage 20mentioning

confidence: 98%

Section: Stage 17mentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Liver development in the rat and in man during the embryonic period (Carnegie stages 11-23)

Godlewski¹,

Gaubert-Cristol

Rouy

et al. 1997

Microsc. Res. Tech.

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“…Additionally, the liver consists of multilayered and irregularly oriented bands of hepatocytes separated by liver sinusoids lined with continuous endothelium and basal membrane (BM). During the maturation of the liver, the structural organization of the scarce and tenuous ECM is altered [Koga, 1971]. The second stage lasts from the 12th week of intrauterine development to the neonatal period.…”

Section: Distribution Of Collagen I Iii and Iv And Laminin In The Hmentioning

confidence: 99%

Distribution of Collagen I, III, and IV and Laminin in the Human Liver during Prenatal Development

Jović

Nikolić

Todorovic

et al. 2018

Cells Tissues Organs

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In the absence of systematized data on the extracellular matrix components during prenatal liver development, the present study aimed to investigate the time of appearance and distribution of collagen types I, III, and IV and laminin. The study material included embryonic and fetal livers, aged 7–37 weeks, categorized into 3 trimesters. The material was stained using hematoxylin-eosin and immunohistochemistry methods for the identification of collagen I, III, and IV and laminin. Collagen I was detected near the end of the first trimester in the capsules and walls of interlobular veins. As the liver matures, collagen I is increasingly abundant in the capsules, portal area connective tissues, arterial walls, interlobular veins, sinusoids, and central veins. Collagen III and collagen IV appear in the middle of the first trimester in the capsules, portal areas, and walls of central veins, as well as the sinusoids particularly. In trimesters 2 and 3, these collagens are increasingly present in all the structures, but collagen IV is also present in nerve fibers. Laminin is sporadically present adjacent to the sinusoids in trimester 1, while in trimesters 2 and 3 this protein commonly appears in the walls of arteries and interlobular veins, in the basal membrane of bile ducts, and in nerve fibers. The contents of collagen I, III, and IV increase during prenatal development in the liver capsule, arterial and vein walls, sinusoids, and portal area. Laminin expression is consistent with that of the collagens with the exception that, within lobules, laminin disappears with liver maturation.

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“…8). In the periportal connective tissue, trabeculae of clear cuboidal cells, organized in cords of ductal cells ( fig.9), were identified as the future biliary ducts developed at the junction between portal vein and hepatic parenchyma and called the ductal plates [Koga. 1971;Ruebner et al, 1990;Shiojiri, 1984: Van Evken et al, 1988.…”

Section: Stages 19 and 20mentioning

confidence: 99%

Liver Development in the Rat during the Embryonic Period (Carnegie Stages 15–23)

Godlewski

Gaubert-Cristol

Rouy

et al. 1997

Cells Tissues Organs

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Hepatic and biliary structures appearing during embryonic Carnegie stages 15–23 were analyzed in OFA rat embryos. The group of rats with crown rump length 7.5–16 mm and 12.8–16 days after coitus yielded 55 specimens (23 of stages 15–16, 20 of stages 17–18, 9 of stages 19–22 and 3 of stage 23). The embryos were submitted to serial histological sections with graphic reconstructions. From stage 15 to the end of the embryonic period, the hepatic gland and its vascular channels (transverse portal sinus and hepatocardiac veins) presented considerable enlargement while hematopoietic function appeared. At stage 17, occlusion due to epithelial proliferation was evident in the hepatic duct. At stage 18, the duct became recanalized and assured the continuity between liver cells and gut. From stage 18 to 23, biliary ductules developed in periportal connective tissue forming ductal plates which received biliary caniculi. Except for the gallbladder which is never present in the rat, similarity and presence of the same hepatic structures in man and in the rat during the embryonic period stages 15–23 suggest that the rat is a good experimental model for liver development and will be useful in the understanding of congenital anomalies.

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Morphogenesis of intrahepatic bile ducts of the human fetus

Cited by 61 publications

References 15 publications

Liver development in the rat and in man during the embryonic period (Carnegie stages 11-23)

Liver development in the rat and in man during the embryonic period (Carnegie stages 11-23)

Distribution of Collagen I, III, and IV and Laminin in the Human Liver during Prenatal Development

Liver Development in the Rat during the Embryonic Period (Carnegie Stages 15–23)

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