Morphogenetic studies of the rabbit. XXIV. The weight and thickness of the ventricular walls in the rabbit heart

Latimer, Homer B.; Sawin, P. B.

doi:10.1002/ar.1091350210

Cited by 9 publications

(2 citation statements)

References 10 publications

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“…Furthermore, EA mesh is reduced even further to values as low as 0.01 N/m, upon noncoplanar buckling of interconnects, as in SI Appendix. These values are exceptionally small compared with cardiac tissue, which has EA cardiac = 76 N/m and EI cardiac = 23 μN-m for 1.9-mm-thick ventricular walls (36) and an elastic modulus of E heart = 40 kPa (37). By comparison with previously reported active cardiac and neural mapping sheets [bending stiffness 31 N-m (6)], the web devices presented in this study are 5 orders of magnitude softer and comparable to passive devices used on the brain (34).The most favorable epidermal electronics had values of EA = 4.2 N/m and EI = 0.3 nN-m (35).…”

Section: Resultsmentioning

confidence: 89%

Electronic sensor and actuator webs for large-area complex geometry cardiac mapping and therapy

Kim

Ghaffari

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

221

167

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Curved surfaces, complex geometries, and time-dynamic deformations of the heart create challenges in establishing intimate, nonconstraining interfaces between cardiac structures and medical devices or surgical tools, particularly over large areas. We constructed large area designs for diagnostic and therapeutic stretchable sensor and actuator webs that conformally wrap the epicardium, establishing robust contact without sutures, mechanical fixtures, tapes, or surgical adhesives. These multifunctional web devices exploit open, mesh layouts and mount on thin, bio-resorbable sheets of silk to facilitate handling in a way that yields, after dissolution, exceptionally low mechanical moduli and thicknesses. In vivo studies in rabbit and pig animal models demonstrate the effectiveness of these device webs for measuring and spatially mapping temperature, electrophysiological signals, strain, and physical contact in sheet and balloon-based systems that also have the potential to deliver energy to perform localized tissue ablation.flexible electronics | semiconductor nanomaterials | stretchable electronics | implantable biomedical devices | cardiac electrophysiology C ardiac arrhythmias occur in all component structures and 3D regions of the heart, resulting in significant challenges in diagnosis and treatment of precise anatomic targets (1). Many common arrhythmias, including atrial fibrillation and ventricular tachycardia, originate in endocardial substrates and then propagate in the transverse direction to affect epicardial regions (1, 2). Characterizing arrhythmogenic activity at specific regions of the heart is thus critical for establishing the basis for definitive therapies such as cardiac ablation (3). Advanced tools that offer sufficient spatial resolution (<1 mm) and intimate mechanical coupling with myocardial tissue, but without undue constraints on natural motions, would therefore be of great clinical importance (4-6). To date, cardiac ablation procedures have largely relied on point ablation catheters deployed in the endocardial space (1, 5, 7-9). Although successful in the treatment of simple arrhythmias originating in and around the pulmonary veins, these devices are poorly suited for treating complex arrhythmias, such as persistent atrial fibrillation (10-13), that arise from various sites inside the left atrium. Other classes of devices have demonstrated the utility of spatiotemporal voltage mapping using various modes of operation, including noninvasive surface mapping designs (14, 15), epicardial voltage-mapping "socks" (16-20), and endocardial contact and noncontact catheters, with densities approaching 64 electrodes (21-31). These solutions all exploit arrays of passive metal wirebased electrodes integrated on wearable vests and socks (14-20) or catheter systems (21-26) for mapping of complex arrhythmias. Building such mesh structures requires manual assembly and is only possible because the individual wires are millimeter scale in diameter and thus sufficiently large to be threaded to form a mesh.Fo...

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Section: Resultsmentioning

confidence: 89%

Electronic sensor and actuator webs for large-area complex geometry cardiac mapping and therapy

Kim

Ghaffari

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

221

167

View full text Add to dashboard Cite

show abstract

“…At gross post‐mortem examination, the atria were bilaterally moderately enlarged. The right and left ventricular walls measured 2 and 6 mm, respectively, which is thicker than available reference ranges by 8 and 32%, respectively (Latimer and Sawin 1959). The left atrium contained a thrombus (Fig 1).…”

Section: Case Historiesmentioning

confidence: 95%

Congestive heart failure in two pet rabbits

Lord

Devine

Smith

2010

J of Small Animal Practice

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This case report describes congestive heart failure with pleural effusion in two middle-aged, pet house rabbits. Both had a history of acute onset dyspnoea, weakness and weight loss. Bi-atrial enlargement was seen on echocardiography in both rabbits. One rabbit had atrial fibrillation and ventricular premature complexes identified on electrocardiography. There was a radiographically evident pleural effusion in both rabbits and thoracocentesis was undertaken in one rabbit. These findings were confirmed on post-mortem examination. The aetiology for the underlying heart disease was not found, but the potential types of cardiomyopathies are discussed.

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Morphogenetic studies of the rabbit. XXXI. Weights and linear measurements of some of the bones of 65 race III rabbits

Latimer

Sawin

1962

Am. J. Anat.

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Morphogenetic studies of the rabbit. XXIV. The weight and thickness of the ventricular walls in the rabbit heart

Cited by 9 publications

References 10 publications

Electronic sensor and actuator webs for large-area complex geometry cardiac mapping and therapy

Electronic sensor and actuator webs for large-area complex geometry cardiac mapping and therapy

Congestive heart failure in two pet rabbits

Morphogenetic studies of the rabbit. XXXI. Weights and linear measurements of some of the bones of 65 race III rabbits

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