Morphogenetic studies of the rabbit. VII. Aortic arch variations in relation to regionally specific growth differences

Sawin, P. B.; Edmonds, Henry W.

doi:10.1002/ar.1091050302

Cited by 23 publications

(7 citation statements)

References 9 publications

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“…The multiple patterns of the arteries are also normally found in other structures (see Lippert and Pabst, ), such as the branching patterns of the aortic arch (Sawin and Edmonds, ; Noden and de Lahunta, ), the splenic artery (Michels, ), the renal artery (Ozkan et al, ) and the forelimb arteries (Matsumoto et al, ; Rodríguez‐Niedenführ et al, ; reviewed by Rodríguez‐Niedenführ et al, ). As in the aortic arch, sometimes the abnormal human patterns and other common animal patterns have identical topological relationships (Noden and de Lahunta, ), as seen in the a.gsac in the current study.…”

Section: Discussionmentioning

confidence: 84%

Anatomy of the Murine Hepatobiliary System: A Whole‐Organ‐Level Analysis Using a Transparency Method

Higashiyama

Sumitomo

Ozawa

et al. 2015

The Anatomical Record

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The biliary tract is a well-branched ductal structure that exhibits great variation in morphology among vertebrates. Its function is maintained by complex constructions of blood vessels, nerves, and smooth muscles, the socalled hepatobiliary system. Although the mouse (Mus musculus) has been used as a model organism for humans, the morphology of its hepatobiliary system has not been well documented at the topographical level, mostly because of its small size and complexity. To reconcile this, we conducted whole-mount anatomical descriptions of the murine extrahepatic biliary tracts with related blood vessels, nerves, and smooth muscles using a recently developed transparentizing method, CUBIC. Several major differences from humans were found in mice: (1) among the biliary arteries, the arteria gastrica sinistra accessoria was commonly found, which rarely appears in humans; (2) the sphincter muscle in the choledochoduodenal junction is unseparated from the duodenal muscle; (3) the pancreatic duct opens to the bile duct without any sphincter muscles because of its distance from the duodenum. This state is identical to a human congenital malformation, an anomalous arrangement of pancreaticobiliary ducts. However, other parts of the murine hepatobiliary system (such as the branching patterns of the biliary tract, blood vessels, and nerves) presented the same patterns as humans and other mammals topologically. Thus, the mouse is useful as an experimental model for studying the human hepatobiliary system. Anat Rec, 299:161-172, 2016. V C 2015 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 84%

Anatomy of the Murine Hepatobiliary System: A Whole‐Organ‐Level Analysis Using a Transparency Method

Higashiyama

Sumitomo

Ozawa

et al. 2015

The Anatomical Record

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“…In reaching this conclusion, two ®elds of morphological endpoints were excluded: (1 ) due to diverging methods, the description of the ossi®cation status at hysterectomy has to be understood as being more speci®c for the corresponding laboratory than for the strain, and (2 ) the most dominant spontaneous changes at the A. carotis and at the aortic arch in the Himalayan rabbit (Table 4) were not reported before the year 1998 in the Biberac h laboratory or for the remaining laboratories and the strains discussed above. However, in general, there is evidence in the literature that diverging aortic anatom y is a typical feature of the rabbit, but with no indication that it is speci®c to any strain or species (Savin & Edmonds 1949, Calow 1983.…”

Section: Him a La Ya N Ra B B Itmentioning

confidence: 99%

The Himalayan rabbit (Oryctolagus cuniculus L.): spontaneous incidences of endpoints from prenatal developmental toxicity studies

Viertel

Trieb

2003

Lab Anim

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SummaryT he historical database represents the spontaneous, i.e. normal changes of charact ers, in laboratory animals, and is a must for the assessment of toxic effects of compounds. For the Himalayan rabbit (CHBB:HM , SPF) bac kground data were collected from the control groups of regulatory studies between 1968±1999 in the Biberach laboratory of Boehringer Ingelheim (Germany). In the present study these data were compared with the bac kground data from the years 1974±1984, with those from the Ingelheim laboratory, Germany (1977±1984) and those from the breeding colony at Kawanishi, Japan (1971±1991, 1972±1984 ).Fertilit y in the Biberach laboratory was relatively constant through the years, due to the strict breeding system. Litter parameters (corpora lutea, implantations and viabl e fetuses), including fetal sex distribution and fetal weight, were constant in the Biberac h laboratory through the years and compared well with the dat a from Ingelheim and Kawanishi.From these three laborat ories the results of spontaneous changes in fetal morphology above 0.1% incidence suggest a pattern of deviations from the Ba upla n (fundam ental body plan ). T hese comprise synosteosis of sternebrae, lumbar (additional ) ribs, hypoplasia of 12th rib, status of ossi®cation, aplasia of gall bladder, hypoplasia of gal l bladder, incompletely subdivided lung, dilated ventricle of heart, deviat ions at the A. carotis and at the aortic arch and¯exure of paw. T he absence of a time-dependent statistical trend indicates that the spontaneous change of endpoints remained constant through the tim e axis.Comparison with the spontaneously changed fetal morphology of the other strains (NZW, JW, SF rabbits ) does not provide support for their being a totally strain-speci®c pattern, and this pattern may be closer to the species than speci®c to a single strain. T he ®rm patterns of deviat ions in fetal morphology provide suitable and valuable markers for assessing toxic effects on ontogenesis. According to our experience these morphological endpoints react very sensitively to teratogenic compounds, which is dem onstrat ed by increased incidences. Our knowledge of evolution of organisms and of mechanisms leading to morphological deviations points to a strict selection of phenotypes. For laboratory anim als the decisive selection factors are de®ned by man. T hese are nutritive factors, environmental conditions, the mating system , handling and treatm ent, and experimental design. All these factors have to be held constant through the years, which is an absolute pre-condition for the applicati on of valid historical data.T he Himalayan rabbit is highly suitable for use in developmental toxicity studies due to the stability of reproductive data within the same laboratory over a period of more than 30 years, due to the similarity of reproductive data am ong three different laboratories, and due to an absence of relevant differences to the reproductive data of other rabbit strains.

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“…There are many variations in this arrangement, however. These variations have been studied extensively in the past, in humans as well as in other species, and have been divided into different categories (Parsons 1902;Poynter 1916;Baldwin 1920;Adachi 1928 ;Hammond 1937;Sawin and Edmonds 1949;Pontes 1963;Szy et al 1966;Tsukise et al 1972;Angell-James 1974;Binet and Langlois 1977;Boechat et al 1978). Variations due to particular conditions such as right arch, aortic ring, and retro-esophageal right subclavian artery are in a rather special category.…”

Section: Introductionmentioning

confidence: 99%

Continuum analysis of common branching patterns in the human arch of the aorta

Zamir

Sinclair

1990

Anat Embryol

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A model is proposed for describing common variations in the arrangement of branches on the arch of the human aorta, and the model is used to analyze data from 123 human arches. The analysis allows the observed variations to fall freely along a continuous spectrum, rather than be confined to discrete categories as is commonly done at present. The results thus describe these variations in a more natural way and throw some new light on their likely source.

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Morphogenetic studies of the rabbit. VII. Aortic arch variations in relation to regionally specific growth differences

Cited by 23 publications

References 9 publications

Anatomy of the Murine Hepatobiliary System: A Whole‐Organ‐Level Analysis Using a Transparency Method

Anatomy of the Murine Hepatobiliary System: A Whole‐Organ‐Level Analysis Using a Transparency Method

The Himalayan rabbit (Oryctolagus cuniculus L.): spontaneous incidences of endpoints from prenatal developmental toxicity studies

Continuum analysis of common branching patterns in the human arch of the aorta

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