Morphologic and phenotypic changes of human neuroblastoma cells in culture induced by cytosine arabinoside

Ponzoni, Mirco; Lanciotti, Marina; Melodia, A.; Casalaro, Antonella; Cornaglia-Ferraris, P.

doi:10.1016/0014-4827(89)90196-1

Cited by 16 publications

(7 citation statements)

References 17 publications

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“…IFN-~'-induced LAN-5 cells rapidly acquired a pattern similar to that observed in mature ganglioneurocytes [18]. This cell line expresses high levels of the high-affinity IFN-7 receptor (Ka = 4.53 +_.…”

Section: Resultsmentioning

confidence: 56%

“…It has been previously shown that IFN-7 is able to promote concentration-dependent growth inhibition of a neuroblastoma cell line, LAN-5, together with striking morphological changes and modulation of membrane and cytoskelctal proteins [18]. IFN-~'-induced LAN-5 cells rapidly acquired a pattern similar to that observed in mature ganglioneurocytes [18].…”

Section: Resultsmentioning

confidence: 82%

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Stimulation of receptor‐coupled phospholipase A₂ by interferon‐γ

1992

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The biomolecular mechanisms that mediate signal transduction by type 11 (γ) interferon (IFN) are poorly understood. IFN‐γ is a potent growth inhibitory cytokine also endowed with antiviral, immunomodulatory, and differentiating activities on various cell targets, including neural cells. IFN‐γ induced a rapid and transient activation of phospholipase A2 in LAN‐5, a human neuroblastoma cell line. A consequence of phospholipase A2 activation was the release of arachidonic acid and the generation of lysophospholipids from membrane phospholipids. Treatment of pre‐labeled LAN‐5 cells with a receptor‐saturating concentration of IFN‐γ led to a time‐dependent release of [3H]arachidonic acid into the culture media and generation or [32P]lysophosphatidylcholine. Pretreatment of cultures with the phospholipase A2 inhibitor, bromophenacyl bromide, markedly inhibited both [3H]arachidonic acid release and lysophosphatidylcholine production induced by IFN‐γ treatment. Pretreatment of LAN‐5 cells with nordihydroguaiaretic acid, a lipoxygenase inhibitor, or with indomethacin, a cyclooxygenase inhibitor, amplified the release of[3H]arachidonic acid and production of lysophosphatidylcholine induced by non‐saturating concentrations of IFN‐γ. In parallel, and with the same time‐dependent effect, a significant decrease in phosphatidylcholine labeling was observed in IFN‐γ‐treated cells, further indicating that a potential signal transduction mechanism of IFN‐γ is the hydrolysis of membrane phosphatidylcholine by phospholipase A2.

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Section: Resultsmentioning

confidence: 56%

Section: Resultsmentioning

confidence: 82%

Stimulation of receptor‐coupled phospholipase A₂ by interferon‐γ

1992

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“…Tumor cells with different differentiations could produce different levels and patterns of catecholamine secretion. 5,6 Therefore, close monitoring of BP is advocated to watch out for the development of HT during the therapy of neuroblastoma. We believe that it has been an obligatory practice for every patient to have their BP recorded before the start of the chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Variants of Cardiomyopathy and Hypertension in Neuroblastoma

Kwok

Cheng

et al. 2014

Journal of Pediatric Hematology/Oncology

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Catecholamine-associated cardiomyopathies caused by neuroblastoma have rarely been reported. We are reporting 2 cases of neuroblastoma associated with hypertension and severe cardiomyopathic changes in different extremes. One case was dilated cardiomyopathy with heart failure, and the other showed echocardiographic features simulating hypertrophic obstructive cardiomyopathy. Both girls had high levels of urine catecholamines on presentation. Anthracycline group of chemotherapy was avoided. Chemotherapy and tumor resection resulted in successful normalization of blood pressure and regression of cardiomyopathic changes. Blood pressure and cardiomyopathic changes should be monitored not only at presentation, but also during the treatment for neuroblastoma.

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“…The catecholamine production of the residual neuroblastoma cells in the tibia must have increased during the therapy. It is well-established that chemotherapeutic agents are capable of changing the differentiation of neuroblastoma [12][13][14]. However, the relationship between catecholamine production and morphological differentia- Chromatography of plasma catecholamines from both femoral veins: the adrenaline concentration tion is uncertain.…”

Section: Discussionmentioning

confidence: 99%

Development of hypertension in neuroblastoma during therapy: A case report

Wolff

Bauch

Roessner

et al. 1993

Med. Pediatr. Oncol.

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A case of stage 4 neuroblastoma that developed excessive hypertension on day 120 of chemotherapy is presented. The tumor initially had responded well to chemotherapy; however, while the tumor mass decreased, plasma and urine catecholamines and the blood pressure increased. The plasma concentrations of noradrenaline, adrenaline, and dopamine increased to 26.4, 1.8, and 36.2 micrograms/l, respectively. The profile of catecholamine metabolites changed: on day 150 of therapy, noradrenaline, adrenaline, and dopamine levels were increased, whereas HVA and VMA levels were decreased when compared to day 1 of therapy. The only residual neuroblastoma tissue visible on MIBG scintigraphy on day 150 of treatment was a metastasis in the left tibia which was irradiated with 24 Gy. The adrenaline concentration in the left femoral vein was twice as high compared to the right femoral vein. A treatment, possibly radiation-associated tumor cell alteration resulting in a different catecholamine production, is discussed.

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Morphologic and phenotypic changes of human neuroblastoma cells in culture induced by cytosine arabinoside

Cited by 16 publications

References 17 publications

Stimulation of receptor‐coupled phospholipase A₂ by interferon‐γ

Stimulation of receptor‐coupled phospholipase A₂ by interferon‐γ

Variants of Cardiomyopathy and Hypertension in Neuroblastoma

Development of hypertension in neuroblastoma during therapy: A case report

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Morphologic and phenotypic changes of human neuroblastoma cells in culture induced by cytosine arabinoside

Cited by 16 publications

References 17 publications

Stimulation of receptor‐coupled phospholipase A2 by interferon‐γ

Stimulation of receptor‐coupled phospholipase A2 by interferon‐γ

Variants of Cardiomyopathy and Hypertension in Neuroblastoma

Development of hypertension in neuroblastoma during therapy: A case report

Contact Info

Product

Resources

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Stimulation of receptor‐coupled phospholipase A₂ by interferon‐γ

Stimulation of receptor‐coupled phospholipase A₂ by interferon‐γ