Morphological, anatomical and cytogenetical investigations in sexually anomalous goats

Yadav, B. R.; Singh, Charan; Kumar, Parveen; Tomer, O. S.; Yadav, J. S.

doi:10.1016/0921-4488(93)90004-2

Cited by 7 publications

(5 citation statements)

References 13 publications

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“…In consequence, the genital system of a female twin becomes masculinized. Sporadic cases of freemartinism have been also observed in goats, but with low frequency, not exceeding 1% (3,4).…”

Section: Introductionmentioning

confidence: 99%

Polledness intersex syndrome in goats – molecular and histological aspects

Szatkowska¹,

Zaborski²,

Proskura³

et al. 2014

Turk J Vet Anim Sci

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Polledness intersex syndrome (PIS) is a phenomenon associated with 2 distinct conditions occurring in goats, namely polledness and intersexuality. The first is a trait exhibiting complete dominance, whereas the latter is recessive. The extreme case of intersexualism is complete sex reversal, which is observed only in females (60,XX). The trait PIS is inherited in a recessive manner and caused by deletion of 11.7 kbp DNA on chromosome 1q43. Female goats with PIS exhibit a broad range of developmental abnormalities of the sexual system, from only subtle changes to complete sex reversal. The phenotypic diversity in goats with PIS is most likely an effect of complexity of the sexual differentiation process, in which the gene-dosage effect may potentially play a crucial role, in addition to the numerous molecular factors regulating the developmental pathway. The occurrence may explain different degrees of masculinization. Nevertheless, the sex reversal phenomenon appearing in female goats (60,XX) with PIS is not considered a serious problem in breeding programs because properly planned selection of individuals for reproduction can allow for complete exclusion of risk of occurrence of this syndrome in offspring. On the other hand, female goats with PIS are still one of the most suitable animal models for studying complex processes of determination and differentiation of sex in mammals.

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“…In consequence, the genital system of a female twin becomes masculinized. Sporadic cases of freemartinism have been also observed in goats, but with low frequency, not exceeding 1% (3,4).…”

Section: Introductionmentioning

confidence: 99%

Polledness intersex syndrome in goats – molecular and histological aspects

Szatkowska¹,

Zaborski²,

Proskura³

et al. 2014

Turk J Vet Anim Sci

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“…In goats, as it was mentioned earlier, very few cases of freemartinism have been described in detail (Yadav et al 1993); an analogy with cattle and sheep exists, however, in external reproductive organs which, except for enlarged clitoris, most often remain unchanged. Clinical changes in internal parts of a freemartin's reproductive system may be very diverse in form, since their development depends primarily on the sex-specific character of the gonads (Khan and Foley 1994;Vigier et al 1991; S m i t h et al 2003).…”

Section: Discussionmentioning

confidence: 92%

“…This opinion is, however, questionable, since results of studies on goats culled due to infertility have demonstrated that cell chimaerism in such animals occurred with a frequency of 4.85% (Szatkowska et al 2002). So far, only a few cases of freemartinism-affected goats have been reported (Yadav et al 1993), hence presentation of three other cases of goats showing masculinisation changes, which was considered important from a cognitive standpoint.…”

mentioning

confidence: 99%

Freemartinism: Three Cases in Goats

Szatkowska¹,

Zych²,

Udała³

et al. 2004

Acta Vet. Brno

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Szatkowska I., Zych S., Uda∏a J., Dybus A., B∏aszczyk P., P. Sysa, Dàbrowski T: Freemartinism: Three Cases in Goats. Acta Vet Brno 2004, 73: 375-378.The aim of the study was a molecular and cytogenetic analysis of three cases of caprine freemartinism. The objects of the study were three White Improved goats culled due to infertility. The SRY gene was treated as a marker of presence (or absence) of the Y chromosome in the population of the blood nuclear cells carrying XY heterochromosomes, which occurs in a female organism originating from a heterosexual twin birth. In order to confirm cellular chimaerism that had been diagnosed basing on the presence of SRY gene, additional chromosomal analyses were carried out. Our studies have revealed that all three animals had the SRY gene linked with the Y chromosome. Bearing in mind that goats are genetically predestined to twin births, as well as due to a small incidence of clinically or molecularly diagnosed cases of freemartinism, it seems important to carry on studies in this scope, which can create a basis for wider characterisation of this syndrome in the domestic goat.

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“…It is known that in the family Bovidae the female partners are infertile and referred to as freemartins (Miyake et al, 1990). The frequency of freemartins in cattle ranges from 82 to 95% of heterosexual twins (Zhang et al, 1994), in sheep from 1.2% in Finish Mountain to 11.2% in Booroola breed (Dain, 1971;Keszka et al, 2001) and only about 1% in goats (Yadav et al, 1993). The impact of karyotype abnormality such as cell chimerism carrying males is arguable.…”

Section: Resultsmentioning

confidence: 99%

The phenomenon of cell chimerism in goats

Rychlik¹,

Kozubska‐Sobocińska²,

Rejduch³

et al. 2005

Vet. Med. - Czech

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Cell chimerism was diagnosed in goats with test reagents that identify erythrocyte antigens and with bovine probes that paint sex chromosomes. Same-sex and opposite-sex twins and their parents, representing the Fawn Improved breed, were used in the study. Ovine test reagents (anti-Aa, -Be, -Bi, -Bd, -Bb, -Ca, -R) were used to analyse the blood groups of twins. Cytogenetic analysis was based on FISH technique. Identical antigens and incomplete results of the reaction of blood cells with some immune sera showed that these animals had two populations of erythrocytes differing in antigens A 1 , B 2 , B 3 , B 15 and R. The analysis of 100 metaphase plates for each animal, which were subjected to FISH technique using bovine sex chromosome painting probes, showed the presence of two cell lines: 60,XX and 60,XY.

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Morphological, anatomical and cytogenetical investigations in sexually anomalous goats

Cited by 7 publications

References 13 publications

Polledness intersex syndrome in goats – molecular and histological aspects

Polledness intersex syndrome in goats – molecular and histological aspects

Freemartinism: Three Cases in Goats

The phenomenon of cell chimerism in goats

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