Morphological and biological characteristics of mammogram-detected invasive breast cancer

Moezzi, Manijeh; Melamed, Jonathan; Vamvakas, Eleftherios C.; Inghirami, Giorgio; Mitnick, J S; Quish, Astrid; Bose, Shikha; Zelman, G; Roses, Daniel F.; Harris, Monica J.; Feiner, Helen

doi:10.1016/s0046-8177(96)90222-1

Cited by 14 publications

(9 citation statements)

References 10 publications

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“…4 9 33 Because it has been shown that there is a significant correlation between tumour size and proliferative activity, 38 it is not surprising that in our series, which was limited to pT1N0M0 cases, almost two thirds of the tumours were assigned score 1 for mitotic counts. However, with such an unbalanced distribution, the statistical power for assessing the prognostic effect of mitotic counts may be greatly reduced.…”

Section: Discussionmentioning

confidence: 80%

Long term prognostic value of Nottingham histological grade and its components in early (pT1N0M0) breast carcinoma

Frković‐Grazio

Bračko²

2002

Journal of Clinical Pathology

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Aims: To determine the prognostic usefulness of the Nottingham histological grade (NHG) and its components in a series of 270 patients with stage pT1N0M0 breast cancer with a median follow up of 12.5 years. Methods: Microscopic slides were re-examined and the degree of tubule formation, nuclear pleomorphism, and mitotic counts were assessed and scored according to the suggested guidelines. The association with cancer specific survival (CSS) was evaluated by univariate and multivariate analyses. Results: Whereas tumour size, patient age, menopausal status, type of surgery, or adjuvant treatment were not related to prognosis, histological type (p < 0.01) and NHG (p < 0.005) were associated with CSS. When evaluating the components of NHG separately, survival was not related to the score for pleomorphism, but was significantly better in tumours with score 1 or 2 for tubule formation (p < 0.007) and in those with score 1 for mitotic counts (p < 0.006). The two components retained independent significance in multivariate analysis. When the proposed cut off points for mitotic counts were replaced by lower ones based on tertile values, the mitotic index became the strongest prognostic factor (p = 0.0001) and histological type was the only additional factor of independent prognostic significance. Conclusions: These findings confirm the prognostic value of NHG in pT1N0M0 breast carcinoma, show that the evaluation of tubule formation and mitotic rate provides independent prognostic information, and suggest that the proposed cut off points for mitotic counts may be too high for this particular group of tumours.

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Section: Discussionmentioning

confidence: 80%

Long term prognostic value of Nottingham histological grade and its components in early (pT1N0M0) breast carcinoma

Frković‐Grazio

Bračko²

2002

Journal of Clinical Pathology

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“…The findings of Tubiana and Koscielny 53 and Duffy et al 36 offer substantial evidence for worsening grade with increasing tumour size, and the latter authors, studying screen-detected lesions, were careful to exclude length bias. Moezzi et al, 54 comparing screen-detected with symptomatic tumours, have reported that expression of p53 is commoner in the screen-detected lesions. As in the present study, however, ER and PgR expression was not significantly different in the two groups and their conclusion that some tumours may evolve into more aggressive lesions corresponds to ours.…”

Section: Discussionmentioning

confidence: 99%

The Pathological and Biological Nature of Screen‐detected Breast Carcinomas: A Morphological and Immunohistochemical Study

et al. 1997

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“…In addition, most cases were collected in the pre or early mammographic era. In the 1990s, among mammographically screened populations, tubular carcinomas are, on average, smaller than during the premammographic era, as is true of breast cancers generally (4). We report on the morphologic and molecular characteristics of tubular carcinomas of the breast collected since 1995.…”

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confidence: 97%

Tubular Carcinoma of the Breast: Immunohistochemical and DNA Flow Cytometric Profile

Fasano¹,

Vamvakas²,

Delgado³

et al. 1999

The Breast Journal

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Molecular markers of ordinary invasive ductal carcinoma of the breast have been extensively studied and their prognostic significance has been assessed. A common variant of breast cancer, tubular carcinoma, has an excellent prognosis as judged from several clinicopathologic studies. One would assume that tubular carcinomas have "favorable" molecular markers, however, published series of tubular carcinomas do not include molecular markers. We describe the molecular markers of 39 consecutive tubular carcinomas collected between January 1995 and July 1997. DNA ploidy, S-phase, estrogen and progesterone receptor (ER and PR, respectively) expression, and immunoreactivity for MIB-1, p53, and erbB2 were evaluated. Seventy-two percent of tubular carcinomas were DNA diploid, 49% had an S-phase less than 5%, 95% were ER positive, 69% were PR positive, 88% had less than 10% MIB-1-positive cells, 97% were p53 negative, and 97% did not overexpress erbB2 protein. Thus tubular carcinomas exhibit favorable molecular characteristics, which may play a role in their good prognosis.

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Morphological and biological characteristics of mammogram-detected invasive breast cancer

Cited by 14 publications

References 10 publications

Long term prognostic value of Nottingham histological grade and its components in early (pT1N0M0) breast carcinoma

Long term prognostic value of Nottingham histological grade and its components in early (pT1N0M0) breast carcinoma

The Pathological and Biological Nature of Screen‐detected Breast Carcinomas: A Morphological and Immunohistochemical Study

Tubular Carcinoma of the Breast: Immunohistochemical and DNA Flow Cytometric Profile

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