2015
DOI: 10.1002/ca.22519
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Morphological and biomechanical analyses of the subchondral mineralized zone in human sacral facet joints: Application to improved diagnosis of osteoarthritis

Abstract: The anatomy of the facet joint subchondral mineralized zone (SMZ) is the main parameter used in diagnosing osteoarthritis. Usually, a single CT scan slice is used to measure the thickness, but the measurement is highly location-dependent. Bone mineral density (BMD) and porosity could be more reliable than thickness for detecting SMZ sclerosis, and linking them to stiffness can provide insights into the mechanism of osteoarthritis progression. The goal of this study was two-fold: (1) to assess spatial heterogen… Show more

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Cited by 10 publications
(3 citation statements)
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“…Osteoarthritis (OA) is a musculoskeletal disease that induces degeneration of cartilage, subchondral bone, and joint and tissue mechanics alterations [ 1 , 2 , 3 , 4 , 5 ]. Affecting more than 32.5 million adults in the United States alone, OA is the second most costly health condition treated in US hospitals [ 6 ], accounting for $16.5 billion, or 4.3%, of the combined cost of all hospitalizations [ 7 ].…”
Section: Introductionmentioning
confidence: 99%
“…Osteoarthritis (OA) is a musculoskeletal disease that induces degeneration of cartilage, subchondral bone, and joint and tissue mechanics alterations [ 1 , 2 , 3 , 4 , 5 ]. Affecting more than 32.5 million adults in the United States alone, OA is the second most costly health condition treated in US hospitals [ 6 ], accounting for $16.5 billion, or 4.3%, of the combined cost of all hospitalizations [ 7 ].…”
Section: Introductionmentioning
confidence: 99%
“…Regarding vascular porosity geometrical properties and percentage, values obtained with our new algorithm spread in the range of (±41.51). Our results regarding CC, SMZ and SB thickness shows that it doesn't present homogeneous values as it has been previosuly found in human (Berteau et al 2015).…”
Section: Resultsmentioning
confidence: 42%
“…Unfortunately, these facet joint grading systems often have no reliability analysis or fail to meet the current recommendations for reliability (Little et al, 2015). However, studies assessing the validity of clinical imaging based grading systems by comparative investiga-tions with microstructural data have been completed for other joints, though rarely for lumbar facet joints (Berteau et al, 2015;Gersing et al, 2016;Hawellek et al, 2016;Reina et al, 2016;Han et al, 2017).…”
Section: Introductionmentioning
confidence: 99%