Morphological and Cellular Features of Innate Immune Reaction in Helicobacter pylori Gastritis: A Brief Review

Ieni, Antonio; Barresi, Valeria; Rigoli, Luciana; Fedele, Francesco; Tuccari, Giovanni; Caruso, Rosario Alberto

doi:10.3390/ijms17010109

Cited by 28 publications

(30 citation statements)

References 26 publications

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“…Approximately, 20% of cancer deaths worldwide are associated with unresolved infection or chronic inflammation; moreover, prolonged inflammation can lead to mucosal atrophy, which in some patients precedes neoplastic development [4]. In particular, unresolved inflammation may create a microenvironment facilitating cellular transformation and chronic tissue damage.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, it may trigger repair response including growth and survival factors, tissue-remodeling enzymes, and immune regulatory cytokines [5]. However, the role of immune cell populations in gastric cancerogenesis has not been yet fully clarified [4]. Neutrophils, mast cells, eosinophils, and dendritic cells may directly infiltrate foveolar epithelium, whereas the lamina propria is permeated by mononuclear cells, such as lymphocytes, macrophages, and plasma cells [6–10].…”

Section: Introductionmentioning

confidence: 99%

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Mast Cell Interaction with Neutrophils in Human Gastric Carcinomas: Ultrastructural Observations

Ieni

Barresi

Branca

et al. 2016

Analytical Cellular Pathology

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Aim. The role of mast cells in cell-cell immune interactions has received increasing attention, although their functional interaction with neutrophils still remains to be clarified in tumors. The aim of the present study was to investigate the association between mast cells and neutrophils in a series of gastric carcinomas (GC). Patients and Methods. 52 surgically resected GC specimens were routinely processed for both light and electron microscopy. Only cases showing both mast cells and neutrophils in the tumor stroma were considered in the analysis. Results. Only 9 GC (M : F = 5 : 4; age range: 50–82 years) showed both mast cells and neutrophils in the tumor stroma. At ultrathin sections, we identified heterotypic aggregation and intermingling of mast cells and neutrophils. Mast cells had mature phenotype and showed full complement of granules with homogeneous, scroll, particle, and mixed pattern. In addition, we found normal-appearing or early apoptosis showing neutrophils. Conclusion. Our histological findings showed the likely interaction between mast cells and neutrophils in GC. We hypothesize that the granular content of mast cells may be released in small quantity through a mechanism called “kiss-and-run fusion,” which is alternative to well-known massive anaphylactic or piecemeal degranulation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mast Cell Interaction with Neutrophils in Human Gastric Carcinomas: Ultrastructural Observations

Ieni

Barresi

Branca

et al. 2016

Analytical Cellular Pathology

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“…In particular, infiltration of the monocytes/macrophages into the lamina propria is a major characteristic of H. pylori-induced chronic infection [56]. H. pylori induces the secretion of some pro-inflammatory cytokines such as IL-1β, IL-6 and IL-8 from human monocytes and macrophages.…”

Section: H Pylori Induces Tlr2-related Signaling In Macrophagesmentioning

confidence: 99%

Toll-like receptor 2: An important immunomodulatory molecule during Helicobacter pylori infection

et al. 2017

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“…Значение его часто недооценивается в клинической практике [1]. Предполагается, что Helicobacter pylori (H. Pylori) представляет собой специфическую особенность в слизистой оболочке желудка и является основным этиологическим фактором хронического гастрита, гастродуоденальной язвы, аденокарциномы желудка и В-клеточной лимфомы MALT [2,3].…”

Section: Introductionunclassified

Structural and functional changes in the mucous membrane of the stomach and duodenum in miners of Kryvbas, who suffer from chronic gastroduodenitis (clinical and morphological study).

Vasilenko¹,

Burtniak²

2018

Morphologia

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© Morphologia. -2018. -Т. 12, № 3. -С. 31-37. © А.М. Василенко, Т.З. Буртняк, 2018  burtniak@i.ua Vasilenko A.M., Burtniak T.Z. Structural and functional changes in the mucous membrane of the stomach and duodenum in miners of Kryvbas, who suffer from chronic gastroduodenitis (clinical and morphological study). ABSTRACT. Background. Clinical and experimental observations of many authors indicate the influence of industrial and professional factors of mining enterprises on the occurrence, the nature of the course of diseases of the stomach and duodenum.Objective. The aim of the work was to study the morphological and functional changes in the mucous membrane of the stomach and duodenum in the miners of Kryvbas, who suffer from chronic gastroduodenitis, to isolate the main diagnostic signs of the disease. Methods. 145 workers of Krivbass industrial enterprises suffering from chronic gastroduodenitis were examined. Male patients aged 30 to 60 years, work experience is more than 10 years. The first group includes 102 miners having professional insalubrity, the second group comprised 43 patients with chronic gastroduodenitis who do not have contact with occupational insalubrity. Results. Morphological studies have shown that with chronic gastroduodenitis inflammatory and atrophic changes in most patients predominate in one of the two organs involved in the pathological process -in the stomach or duodenum. Thus, in the ulcerative form of chronic gastroduodenitis, the mucosa of the duodenum is more deeply affected, with a possible disruption of its neurohumoral function, and in case of a gastritis-like form, deeper lesions are observed in the gastric mucosa. A direct correlation was established between the length of service, the duration of the disease, and the prevalence of inflammatory-atrophic changes in the gastroduodenal zone. Conclusion. With chronic gastroduodenitis, deeper lesions of the mucous membrane of the stomach and duodenum are observed compared with patients who do not have no contact with occupational insalubrity. At miners, inflammatory and atrophic changes are more pronounced in the mucosa of the duodenum than in the stomach, which causes a higher incidence of ulcerative form of chronic gastroduodenitis.

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Morphological and Cellular Features of Innate Immune Reaction in Helicobacter pylori Gastritis: A Brief Review

Cited by 28 publications

References 26 publications

Mast Cell Interaction with Neutrophils in Human Gastric Carcinomas: Ultrastructural Observations

Mast Cell Interaction with Neutrophils in Human Gastric Carcinomas: Ultrastructural Observations

Toll-like receptor 2: An important immunomodulatory molecule during Helicobacter pylori infection

Structural and functional changes in the mucous membrane of the stomach and duodenum in miners of Kryvbas, who suffer from chronic gastroduodenitis (clinical and morphological study).

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