Morphological and Functional Status of Upper Gastrointestinal Tract in Children With Metabolic Syndrome

Бокова, Т. А.; Кошурникова, А. С.; Терещенко, С. Г.

doi:10.18786/2072-0505-2015-42-46-50

Cited by 3 publications

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“…With an increase in the degree of obesity, the frequency of HP contamination increases (from 42% at grade I to 70% at grade IV obesity). [8,9]. Доказана взаимосвязь ожирения с состоянием кишечного микробиома [10,11].…”

Section: Motor-evacuation Disorders In Children With Obesity Recordedmentioning

confidence: 99%

Advantages of the application method for taking a biopsy of the gastric mucosa to assess its functional state and microflora composition in obese children

Кошурникова

Бокова

Терещенко

2021

jour

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Relevance. Obesity is one of the most pressing problems of modern Pediatrics.The purpose of the study: to study the morphofunctional state and features of the composition of the stomach microflora in obese children using and comparing various endoscopic methods of biomaterial sampling.Materials and methods. 164 children aged 7 to 17 years were examined. The main group — 85 obese people, the comparison group‑79 children with normal body weight and digestive diseases. Esophagogastroduodenoscopy was performed, followed by pathomorphological, bacterioscopic, and microbiological examination of the biological material. In addition to sampling the biopsy of the antral part of the stomach with a sterile farcept, 40 patients were additionally taken from the wall biological material by obtaining a smear from the mucous membrane with the author’s endoscopic probe.Research result. The frequency of inflammatory changes IN the gastrointestinal tract was high in both groups and did not depend on body weight. In the main group, duodeno-gastric reflux (DGR) (32–38% и 9–11%, p<0.05) and cardia insufficiency (46–54% и 36–46%, p>0.05) were more often diagnosed. With an increase in the degree of obesity, the total number of refluxes increased — from 45–53% at grade I to 64–75% at grade IV, and DGR — from 12–14% to 49–58%, respectively. The most frequent localization of inflammatory changes in children of the main group was the antral (43–50%), less often — the stomach body (26–30%), while in the comparison group the body was more often affected (42–52%) and less often the antral (24–30%). In most children, regardless of the group (56–66% и 51–65%), chronic gastritis of moderate activity was registered. A high degree was significantly more often detected in the comparison group (14–16% and 24–30%, p<0.05), while a weak degree was detected in children of the main group (16–19% and 5–6%, p<0.05). In children of the main group, H. pylori (HP) was more often detected (45–53% и 25–32%, p <0.05), while 1 degree of contamination was more often determined (43–51% и 39–48%), while in the comparison group — 3 degree (15–18% и 24–30%). With increasing degree of obesity increased frequency of contamination from the antrum, HP — from 36–42% when I level up to 60–71% in IV degree of obesity. When using the application in HP+ children of the main group were more often sown opportunistic pathogens in a more diverse species composition and a more pronounced decrease in planting indigenous microflora, and regardless of HP significantly more prevalent growth of E. coli and Candida. In the presence of DGR, independently of the group, a significantly higher growth of fecal flora and a more pronounced decrease in the seeding of indigenous microflora was obtained.Conclusions.1. A high frequency of inflammatory and functional disorders in children, regardless of body weight, was established.2. Motor-evacuation disorders in children with obesity recorded often (63% and 43%). As the degree of obesity increases, their frequency increases. DGR in obese children is recorded significantly more often (38% and 11%, p<0.05).3. Children with obesity have a higher frequency of registering a low degree of activity of chronic gastritis, and children with normal body weight have a high frequency. The degree of activity of the inflammatory process does not depend on the degree of obesity and the duration of the disease.4. HP in obese children is detected 1.5 times more often than in children with normal body weight; the predominance of low (1 degree) contamination is characteristic. With an increase in the degree of obesity, the frequency of HP contamination increases (from 42% at grade I to 70% at grade IV obesity).5. HP-positive children show significantly higher growth of E. Faecium, S. viridans and Streptococcus faecalis and lower seeding of Lactobacterium and Bifidobacterium.6. DGR contributes to a more pronounced decrease in the growth of indigenous microflora, only Streptoco

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Section: Motor-evacuation Disorders In Children With Obesity Recordedmentioning

confidence: 99%

Advantages of the application method for taking a biopsy of the gastric mucosa to assess its functional state and microflora composition in obese children

Кошурникова

Бокова

Терещенко

2021

jour

Self Cite

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Pathology of the gastrointestinal tract in overweight and obese children

Menshchikova,

Kartseva,

Eliseeva

et al. 2024

Sibirskij nauchnyj medicinskij zhurnal

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Obesity and diseases of the gastrointestinal tract are widespread among the children and have common developmental mechanisms. The article provides a literature review on the relationships between certain pathological conditions of the digestive system (gastroesophageal reflux disease, gastritis, functional intestinal disorders, Crohn’s disease, diverticular disease) in children with overweight and obesity. Excess body weight and obesity can become risk factors for the development of gastrointestinal pathology. The data available in modern literature on changes in the composition of the intestinal and stomach microbiocenosis with increasing body weight are summarized (changes in enterotype, increase in the Firmicutеs/Bacteroides ratio, increase in the number of bacteria Methanobrevibacter, Escherichia coli, Lactobacillus rhamnosus, Lactobacillus delbrueckii and Lactobacillus reuteri). The strains of bacteria that contribute to the anorexigenic effect are considered: Lactobacillus gasseri, some strains of Bifidobacterium, Saccharomyces, Streptococcus and Enterococcus. The pathogenetic aspects of obesity and overweight caused by microbiota are presented: activation of lipid synthesis, breakdown of polysaccharides, absorption of mono- and disaccharides, development of metabolic endotoxemia, etc. Features of the functioning of the autonomic nervous system in obesity in children are presented, indicating the predominance of the hypersympathicotonic variant of autonomic reactivity.

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Pancreatic lesion in children with nephrotic syndrome

Бекмурзаева

Османов

2021

Medicinskij sovet

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Nephrotic syndrome occupies one of the leading places among kidney diseases in children. Scientific studies indicate that edema syndrome, arterial hypertension, disorders on the microcirculatory level occurring in case of nephrotic syndrome contribute to the slowing and reduction of blood flow in the pancreas, which leads to the development of hypoxia and metabolic disorders. Under conditions of metabolic and microcirculatory disorders, as well as against the background of the therapy used in children with nephrotic syndrome the risk of secondary pancreas lesion increases significantly. Pathogenetic treatment of nephrotic syndrome involves the administration of glucocorticosteroid and cytostatic therapy. The study of autopsy materials of the pancreas in children who died of glomerulonephritis revealed histomorphological changes in 35.7% of children in the form of acute interstitial pancreatitis and pancreonecrosis. At the same time there are still few works in the scientific literature, devoted to the study of functional state of the pancreas in children with kidney diseases. The data on pancreatitis prevalence in children are extremely inconsistent. Significant variation in the frequency of pancreatic lesion in children (from 5 to 25%) is most often associated with diagnostic difficulties. Ultrasound examination after a meal (postprandial test) allows to diagnose pancreatic pathology (indirect signs of chronic pancreatitis, reactive pancreatic changes) with higher accuracy (by 23%) than traditional examination. Late diagnosis of pancreatic lesion and lack of correction can significantly affect patients’ health and quality of life. There is a need to study functional state of pancreas in children with nephrotic syndrome to improve understanding of pathogenesis of possible involvement in pathological process and optimization of preventive and therapeutic tactics.

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Morphological and Functional Status of Upper Gastrointestinal Tract in Children With Metabolic Syndrome

Cited by 3 publications

References 0 publications

Advantages of the application method for taking a biopsy of the gastric mucosa to assess its functional state and microflora composition in obese children

Advantages of the application method for taking a biopsy of the gastric mucosa to assess its functional state and microflora composition in obese children

Pathology of the gastrointestinal tract in overweight and obese children

Pancreatic lesion in children with nephrotic syndrome

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