Morphological and immunocytochemical features of Merkel cell carcinoma metastatic to the pancreas diagnosed by endoscopic ultrasound‐guided fine‐needle aspiration

The diagnostic utility of Merkel cell polyomavirus immunohistochemistry in a fine needle aspirate of metastatic Merkel cell carcinoma of unknown primary to the pancreas

“…23 However, metastases to the pancreas are exceedingly rare; only 19 cases have been reported in the literature. [7][8][9][10][11][12][13][14][15][16][17][18][19] In these cases, the pancreas metastases were almost always preceded by nodal recurrence of primary MCCs or concomitant extra-pancreatic metastases.…”

“…We FNA). 8,18,19 We report a case of MCC from an unknown primary manifesting as an axillary mass and a pancreatic metastasis. …”

“…[4][5][6] Pancreatic involvement by MCC is rare with 19 reported cases in the literature. [7][8][9][10][11][12][13][14][15][16][17][18][19] To date, only 8 cases have been diagnosed by endoscopic ultrasound-guided fine-needle aspiration cytology (EUS-FNA). 8,18,19 We report a case of MCC from an unknown primary manifesting as an axillary mass and a pancreatic metastasis.…”

Merkel Cell Carcinoma With Isolated Pancreatic Metastasis

“…Risk factors for MCC include older age, 1 male gender, 5 fair skin, 5 ultraviolet light, 6 immunosuppression (in particular, kidney transplant, 7 lymphoproliferative malignancy, 6 and AIDS 8 ), and radiation exposure. 9 In a SEER (Surveillance, Epidemiology, and End Results) database study of 3870 cases, 94.9% of patients were Caucasian between 60 and 85 years of age. 5 High levels of Merkel cell polyomavirus DNA were found in tumor samples in about 80% of cases of MCC.…”

Comments on and Illustrations of the EFSUMB CEUS Guidelines: Transabdominal and Endoscopic Ultrasound Features of Intrapancreatic Metastases and the Role of Multiparametric Imaging and EUS-Guided Sampling in Rare Pancreatic Tumors

“…Rare intrapancreatic metastases from other primary sites have been described as case reports [118][119][120][121][122][123][124][125][126][127] or have been included individually in studies (see Table 3). These include uterine and ovarian carcinomas, thyroid carcinomas, prostate carcinomas, nephroblastoma, urinary bladder carcinomas, mesenchymal tumors, Merkel cell carcinoma, and other rare entities (Figure 14).…”