Morphological and mechanical changes induced by quercetin in human T24 bladder cancer cells

Adami, Bruno Silveira; Diz, Fernando Mendonça; Gonçalves, Gustavo Petry Oliveira; Reghelin, Camille Kirinus; Scherer, Matheus; Dutra, Artur Pereira; Papaléo, R.M.; Oliveira, Jarbas Rodrigues de; Morrone, Fernanda Bueno; Wieck, Andréa; Xavier, Léder Leal

doi:10.1016/j.micron.2021.103152

Cited by 26 publications

(14 citation statements)

References 63 publications

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“…Finally, our study shows for the first time the morphological and mechanical characteristics of quercetin-treated bladder cancer T24 cells and suggests that it has antitumor effects. We hope this study will serve as a starting point and support for other studies to analyze quercetin for bladder cancer [ 31 ]. Ma et al demonstrated that quercetin inhibits the growth and proliferation of bladder cancer cells and induces apoptosis, which is associated with reduced DNA methylation levels of P16, RASSF1A, and Er β genes and reduced expression of mutP53 and Survivin proteins.…”

Section: Discussionmentioning

confidence: 99%

Global Trends in Research of Treatment on Bladder Cancer with Chinese Medicine Monomer from 2000 to 2021: A Bibliometric Analysis

Zuo

2022

Journal of Oncology

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Bladder cancer is a malignant tumor that occurs on the mucous membrane of the bladder. It is the most common malignant tumor of the urinary system and one of the top ten common tumors in the whole body. This bibliometric analysis was applied to identify the characteristics of global scientific output, the hotspots, and frontiers about treatment on bladder cancer with Chinese medicine monomer over the past 22 years. We retrieved publications published from 2000 to 2021 and their recorded information from Web of Science Core Collection (WoSCC). VOSviewer and CiteSpace were used to analyze bibliometric indicators and visualize the trend and hotspots of researches on bladder cancer with Chinese medicine monomer. Altogether, 658 original articles were reviewed, and the results showed that the annual number of publications (Np) shows an upward trend over the past 22 years as a whole. The US produced the most papers, and the number of citations (Nc) and H -index of the US ranked first. Johns Hopkins University and BJU International were the most prolific affiliation and journal, respectively. Recently, the keywords “NF-kappa B” appeared frequently. Besides, quercetin is the most thorough research in the treatment of bladder cancer with Chinese herbal compound, but whether quercetin is the most potent compound needs further study.

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Section: Discussionmentioning

confidence: 99%

Global Trends in Research of Treatment on Bladder Cancer with Chinese Medicine Monomer from 2000 to 2021: A Bibliometric Analysis

Zuo

2022

Journal of Oncology

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“… S. No Flavonoids Type of cancer Cell model Mechanistic insight Refs. 1 Quercetin Prostate cancer LNCaP, DU-145, and PC-3 ↑ROS, ↓ Akt, ↓NF-κB apoptosis [154] 2 Quercetin Breast cancer MCF-7 ↓Bcl-2, ↓ RIPK1, ↓ RIPK3 [155] 3 Quercetin Lung cancer A549, and H1299 ↑ SIRT1/AMPK [156] 4 Quercetin Bladder cancer T24 ↑Apoptosis, ↓Cellular elasticity [157] 5 Quercetin Hepatocellular carcinoma Breast cancerColorectal cancer cells HepG2, and Hep3B MDA-MB-231 HCT116 ↑Lysosome, transcription factor EB, ROS [158] 6 Luteolin Glioblastoma A172, and U-373MG ↑PARP, ↑autophagy [159] 7 Luteolin Gliomablastoma U251MG, and U87MG ↑ROS/ER, ↑caspase-3/Bax/Bcl-2, ↓ p-PERK/p-eIF2α/ATF4/CHOP [160] 8 Luteolin Colon Cancer HCT116 ↑p53, ↑autophagy [161] 9 Luteolin Breast Cancer MCF7-TamR ↓PI3K/AKT/mTOR [162] 10 Luteolin Hepatocellular cancer Hep3B ↑p21, ↑ER stress [163] 11 Silibinin Pancreatic cancer SW1990 ↑G1 arrest, ↑apoptosis and ↑JNK/SAPK [164] 12 …”

Section: Flavonoids: Understanding About the Structure And Chemistrymentioning

confidence: 99%

Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer: A signature step hinting towards clinical perfection

Tuli

Garg

Bhushan³

et al. 2023

Translational Oncology

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“…It was found that quercetin can induce senescence in cancer cells. In quercetin-treated T24 bladder cancer cells, an increase in the percentage of nuclei during cellular senescence was observed by nuclear morphometric analysis (NMA) ( Adami et al, 2021 ). Furthermore, the immunoreactivity of Lamin B1, p16, and cyclin B1, markers of cellular senescence, was also increased in Colo-320 and Colo-741 cells after treatment with quercetin ( Özsoy et al, 2020 ).…”

Section: Therapeutic Mechanisms Of Quercetin Targeting Non-apoptotic ...mentioning

confidence: 99%

Targeting of non-apoptotic cancer cell death mechanisms by quercetin: Implications in cancer therapy

Yang

Xu²,

Tang³

et al. 2022

Front. Pharmacol.

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The ultimate goal of cancer treatment is to kill cancer cells, based on the use of various therapeutic agents, such as chemotherapy, radiotherapy, or targeted therapy drugs. Most drugs exert their therapeutic effects on cancer by targeting apoptosis. However, alterations in apoptosis-related molecules and thus assisting cells to evade death, eventually lead to tumor cell resistance to therapeutic drugs. The increased incidence of non-apoptotic cell death modes such as induced autophagy, mitotic catastrophe, senescence, and necrosis is beneficial to overcoming multidrug resistance mediated by apoptosis resistance in tumor cells. Therefore, investigating the function and mechanism of drug-induced non-apoptotic cell death modes has positive implications for the development of new anti-cancer drugs and therapeutic strategies. Phytochemicals show strong potential as an alternative or complementary medicine for alleviating various types of cancer. Quercetin is a flavonoid compound widely found in the daily diet that demonstrates a significant role in inhibiting numerous human cancers. In addition to direct pro-tumor cell apoptosis, both in vivo and in vitro experiments have shown that quercetin exerts anti-tumor properties by triggering diverse non-apoptotic cell death modes. This review summarized the current status of research on the molecular mechanisms and targets through which quercetin-mediated non-apoptotic mode of cancer cell death, including autophagic cell death, senescence, mitotic catastrophe, ferroptosis, necroptosis, etc.

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Morphological and mechanical changes induced by quercetin in human T24 bladder cancer cells

Cited by 26 publications

References 63 publications

Global Trends in Research of Treatment on Bladder Cancer with Chinese Medicine Monomer from 2000 to 2021: A Bibliometric Analysis

Global Trends in Research of Treatment on Bladder Cancer with Chinese Medicine Monomer from 2000 to 2021: A Bibliometric Analysis

Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer: A signature step hinting towards clinical perfection

Targeting of non-apoptotic cancer cell death mechanisms by quercetin: Implications in cancer therapy

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