Morphological aspects of the hypothalamic-hypophyseal system

Akmayev, Ildar G.; Fidelina, O. V.

doi:10.1007/bf00220328

Cited by 30 publications

(1 citation statement)

References 23 publications

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“…ewe [8. 9] and hamster [19], Electron-micro scopic studies have also shown that following dexamethasone treatment tanycytes show an increase in synthesis and transport activities, especially in the floor of the third ven tricle [3], However, in adrenalectomized animals there is a decrease in synthesis and transport activities in the floor of the third ventricle. Again, plasma osmolarity changes induce cistern-like structure formation in the tanycytic cytoplasm, suggesting a receptor function [5.…”

Section: Discussionmentioning

confidence: 99%

Morphology and Distribution of Tanycytes in the Third Ventricle of the Adult Rat

Mathew

Singh²

1989

Cells Tissues Organs

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Light microscopy and semithin methacrylate sections were used to study the tanycytic projections and morphology in the floor of the third ventricle of the rat. The tanycytic cell soma was located in the ependyma. The luminal surface showed minute protrusions into the ventricular space and their basal processes projected across the width of the parenchyma of the infundibular region. During their course, tanycytic processes made contact with capillaries in the parenchyma and pial surface, suggesting that they might be involved in uptake and/or delivery mechanisms between the cerebrospinal fluid, hypothalamic cells and blood vessels.

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Section: Discussionmentioning

confidence: 99%

Morphology and Distribution of Tanycytes in the Third Ventricle of the Adult Rat

Mathew

Singh²

1989

Cells Tissues Organs

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Ependymal development, proliferation, and functions: A review

Bruni

1998

Microsc. Res. Tech.

243

129

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A survey of the literature shows that proliferation of ependyma occurs largely during the embryonic and early postnatal periods of development in most species. Differentiation of these cells proceeds along particular regional and temporal gradients as does the expression of various cytoskeletal (vimentin, cytokeratins, glial fibrillary acidic protein) and secretory proteins (S‐100). Turnover declines significantly postnatally, and only low levels of residual activity persist into adulthood under normal conditions. Although the reported response of ependyma to injury is somewhat equivocal, only limited regenerative capacity appears to exist and to varying degrees in different regions of the neuraxis. Proliferation has been most often observed in response to spinal cord injury. Indeed, the ependyma plays a significant role in the initiation and maintenance of the regenerative processes in the spinal cord of inframammalian vertebrates. In the human, however, ependyma appears never to regenerate at any age nor re‐express cytoskeletal proteins characteristic of immature cells. The functions of ependyma including tanycytes, a specialized form of ependymal cell that persists into adulthood within circumscribed regions of the nervous system, are still largely speculative. Fetal unlike mature ependyma is believed to be secretory and is believed to play a role in neurogenesis, neuronal differentiation/axonal guidance, transport, and support. In the adult brain, mature ependyma is not merely an inert lining but may regulate the transport of ions, small molecules, and water between the cerebrospinal fluid and neuropil and serve an important barrier function that protects neural tissue from potentially harmful substances by mechanisms that are still incompletely understood. Microsc. Res. Tech. 41:2–13, 1998 © 1998 Wiley‐Liss, Inc.

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Aqueductal tanycytes in the rabbit brain: A Golgi study

Burnett

Felten

1981

Anat. Rec.

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Utilizing Golgi-Cox impregnation, tanycytes were found in the ependyma of the cerebral aqueduct of the neonatal and adult rabbit. These tanycyte somas showed a variety of shapes, apical projections into the aqueduct, and basal processes (shafts) projecting into the mesencephalon, particularly into the periaqueductal gray (PAG). The shafts showed a variety of branching patterns, and sometimes abutted or terminated on capillaries or on specific neuronal elements. Other shafts coiled within the PAG or terminated within the neuropil of the mesencephalon. It is possible that these tanycytes provide a route for transport of cerebrospinal-fluid-borne substances from the aqueduct to the neuronal regions and vasculature of the mesencephalon. The presence of these tanycytes with complex branching patterns in proximity to neural and vascular structures suggests a permanent, active role for these specialized ependymal cells.

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Morphological aspects of the hypothalamic-hypophyseal system

Cited by 30 publications

References 23 publications

Morphology and Distribution of Tanycytes in the Third Ventricle of the Adult Rat

Morphology and Distribution of Tanycytes in the Third Ventricle of the Adult Rat

Ependymal development, proliferation, and functions: A review

Aqueductal tanycytes in the rabbit brain: A Golgi study

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