Morphological changes in the kidney, liver and spleen during prolonged administration of iron nanoparticles

Navolokin, Nikita; Maslyakova, Galina N.; Bucharskya, A. B.; Kong, Xiaorui; Зуев, В. В.; Medvedev, B. A.; Ignatiev, Alexander A.; Bochkaryeva, Тat'jana Vladimirovna

doi:10.1088/1742-6596/345/1/012043

Cited by 3 publications

(2 citation statements)

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“…Clinical trials have shown excellent biocompatibility of magnetite nanoparticles [16][17][18]. Low toxicity was also determined in vivo by morphological study of internal organs of laboratory animals after different methods of administration of magnetite nanoparticles [19][20][21].…”

Section: Overviewmentioning

confidence: 99%

Nanoparticles and nanostructured carriers for drug delivery and contrast enhancement

Godage

Bucharskaya

Navolokin

et al. 2016

Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and L

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Currently, nanotechnologies are widely used in science and industry. It is known that the application of drug delivery nanostructured carriers for biomedicine is one of the promising areas of nanotechnology. Nanostructured carriers can be used in the diagnosis process for detecting a neoplastic tumor cells in peripheral blood, for contrast enhancement on magnetic resonance imaging (MRI), as well as for targeted drug delivery to tumor tissues. Agents for the targeted delivery (nanoparticles, liposomes, microcapsules, and etc) can affect the healthy tissues and organs, cause side effects and have a toxic effect. Therefore, it necessary to study the morphological changes that occur not only in the "target", such as a tumor, but also the internal organs, taking place under the influence of both the agents for targeted drug delivery and physical impact induced remote controlled drug release. Thus , the aim of our work is selection of the most promising agents for targeted drug delivery to tumor and contrast agents for in vivo visualization of tumor tissue boundaries , as well as their impact on the organs and tissues as results of nanostructured object biodistribution. OVERVIEWAt present time it is difficult to name the area of science, where nanotechnologies have not found their application. A lot of works demonstrate that the range of nanotechnology applications in biomedicine is quite wide, for example, magnetite nanoparticles can be used to enhance contrast and improve diagnostic sensitivity in (MRI) [1-6], targeted delivery [7-9], hyperthemia [10,11], tissue engineering [12]. The magnetite nanoparticles have a considerably lower toxicity as compared with the analogues based on nickel, cobalt and other substances and sufficient magnitude of effective magnetic characteristics [13][14][15]. Magnetite is quite a promising material for biomedical applications, because it does not affect the cardiovascular system [13], its intravenous administration is permitted by U.S. Federal agency of Food and Drug Administration [14]. Clinical trials have shown excellent biocompatibility of magnetite nanoparticles [16][17][18]. Low toxicity was also determined in vivo by morphological study of internal organs of laboratory animals after different methods of administration of magnetite nanoparticles [19][20][21].Stability of nanoparticles is the most important characteristic for the biomedical applications. Surface modification of nanoparticles enables them to ensure not only colloidal stability but also biocompatibility. The aggregation and oxidation were observed for inorganic nanoparticles. Coatings of organic and inorganic nature for surface modification of nanoparticles are used to prevent actions like aggregation, sedimentation and [22][23][24][25]. Gold modifies the surface in such a way that increases the stability of nanoparticles in aqueous solution [26,27]. Dextran and its derivatives have a high biocompatibility and are used for stabilization of nanoparticles [28][29][30]. Nanoparticles stabilized by alginate and chitosa...

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Section: Overviewmentioning

confidence: 99%

Nanoparticles and nanostructured carriers for drug delivery and contrast enhancement

Godage

Bucharskaya

Navolokin

et al. 2016

Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and L

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show abstract

“…Magnetite is quite a promising material for biomedical applications, in different studies indicates that such nanoparticles have low toxicity, good biocompatibility and sufficient magnitude of effective magnetic characteristics [10,11]. Low toxicity was also confirmed by vivo studies and morphological examination of internal organs of animals after different methods of administration of magnetite nanoparticles [12][13][14].…”

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confidence: 99%

The Magnetite Nanoparticles in Theranostic Applications

Bucharskaya¹

2017

JNMR

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Currently, nanotechnologies are widely used in biomedicine, science and industry. It is known that the application of magnetite nanoparticles as nanostructured carriers is one of the promising areas of biomedicine. The formation of polyelectrolyte or nanocomposite microcapsules is widely applied for the coating of magnetic nanoparticles. The microcapsules containing magnetite nanoparticles have good perspectives for theranostics applications, but careful study of their biodistribution and toxicity is necessary to prove the safety of these structures as a diagnostic and therapeutic agents.

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The Morphological Changes in the Internal Organs in Tumor-Bearing Rats at Intravenous Injection of Citrate-Stabilized Magnetite Nanoparticles

et al. 2016

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Morphological changes in the kidney, liver and spleen during prolonged administration of iron nanoparticles

Cited by 3 publications

References 10 publications

Nanoparticles and nanostructured carriers for drug delivery and contrast enhancement

Nanoparticles and nanostructured carriers for drug delivery and contrast enhancement

The Magnetite Nanoparticles in Theranostic Applications

The Morphological Changes in the Internal Organs in Tumor-Bearing Rats at Intravenous Injection of Citrate-Stabilized Magnetite Nanoparticles

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