Morphological Changes in the Mandibular Joint Disk in Temporomandibular Joint Pain Dysfunction Syndrome

Ge, Carlsson; Oberg, T; Bergman, F.; Cm, Fajers

doi:10.3109/00016356709028745

Cited by 39 publications

(8 citation statements)

References 5 publications

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“…In two previous studies some reptesentative radiopaque aieas were examined by x-ray diffraction and histologic metbods and they were found to be calcifications a, Carlsson et al 1967. The radiopaque areas now observed therefore presumably eorresponded to calcifications, as judged from the histologic findings in the present tnaterial.…”

Section: Discussionsupporting

confidence: 53%

“…The deposits were confined to the loose peripheral parts of the disk. In a small series of five surgically removed temporomandibular disks from young patients aged 22-25 years who had had pain for a long time and a reduced range of mobility of the temporomandibular joint, examination with the same technique revealed numerous calcifications in all the disks, and in the dense central part as well (Carlsson et al 1967). The disks also showed increased vaseularization as well as hyalin sclerosis and fraying of collagen tissue, fibrin deposits and other pathologic tissue changes.…”

mentioning

confidence: 99%

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Microradiographic study of human temporomandibular disks obtained at autopsy

Carlsson

Hassleu

Oberg

1973

J Oral Pathology Medicine

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Ninety-six temporomandibular joint disks obtained at autopsy from subjects aged 1 day to 93 years of age and divided into three groups aeeording to dental status were examined mieroradiogiaphieally for ealeifieation.The central pan of the disks .showed no ealeifieations in individuals less Ihan 30 years old, and only a few in persons above 30 years with a good dental status, while the oeeuirence was mueh greater in patients who had lost many or all of their teeth. In ihe peripheral part of the disk there were oceasional calcifiealions already in ehildren, and in elderly individuals tlie ealeifieations were more eommon, but the ficqueney did not appear to vary with the number oi: residual natural teeth or with the degree of aithiosis of Ihe temporomandibular joint.

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Section: Discussionsupporting

confidence: 53%

mentioning

confidence: 99%

Microradiographic study of human temporomandibular disks obtained at autopsy

Carlsson

Hassleu

Oberg

1973

J Oral Pathology Medicine

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“…Disc displacement is associated with degenerative tissue changes, and it is considered to be a risk factor for osteoarthrosis (OA) development with abnormal remodelling of the condyle and mandibular fossa; however, the underlying mechanisms remain unclear (11)(12)(13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

FasL expression in articular discs of human temporomandibular joint and association with osteoarthrosis

Camejo

Almeida

Doetzer

et al. 2013

J Oral Pathology Medicine

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“…Disc displacement is associated with degenerative tissue changes (8,9,11,(20)(21)(22)(23)(24)(25)(26), but the underlying mechanisms remain unclear. Although previous research has demonstrated a correlation between TMJ ID and apoptosis (27)(28)(29)(30), most studies have been done in animal models because of the difficulty in obtaining human material.…”

Section: Introductionmentioning

confidence: 99%

Apoptosis in displaced temporomandibular joint disc with and without reduction: an immunohistochemical study

Loreto

Almeida

Trevilatto

et al. 2011

Journal of Oral Pathology &Amp; Medicine

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Internal derangement (ID) of the temporomandibular joint (TMJ) is due to an abnormal relationship of the articular disc to the mandibular condyle, glenoid fossa and articular eminence. The two most common types of internal derangement are anterior disc displacement with (ADDwR) and without reduction (ADDwoR). Disc displacement is associated with degenerative tissue changes. The histological features of discs from patients with TMJ ID reflect a general remodelling caused by abnormal loading. A correlation has been demonstrated between TMJ ID and apoptosis. Few investigations have addressed the role of apoptosis or caspase activity in TMJ ID. The apoptosis activation process was studied in different areas of discs from 18 patients with ID (both ADDwR and ADDwoR) and four cadavers (controls), with emphasis on the expression of caspase 3, whose activation makes the death process irreversible. The results showed a greater proportion of caspase 3-positive cells in ADDwR and ADDwoR than in control discs. Immunopositivity also varied between disc areas; in particular, in ADDwoR sections labelled cells were significantly more numerous (P < 0.01) in the posterior disc attachment than in the anterior and intermediate bands. In addition, a significantly greater proportion of labelled cells was seen in the anterior (+) and intermediate (++) band of ADDwR compared with ADDwoR discs both bands (P < 0.05). These data suggest the importance of programmed cell death in the progression of TMJ ID.

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Morphological Changes in the Mandibular Joint Disk in Temporomandibular Joint Pain Dysfunction Syndrome

Cited by 39 publications

References 5 publications

Microradiographic study of human temporomandibular disks obtained at autopsy

Microradiographic study of human temporomandibular disks obtained at autopsy

FasL expression in articular discs of human temporomandibular joint and association with osteoarthrosis

Apoptosis in displaced temporomandibular joint disc with and without reduction: an immunohistochemical study

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