Morphological Changes of Human Erythrocytes Induced by Cholesterol Sulphate

Przybylska, M.; M, Faber; Zaborowski, Andrzej; Świętosławski, Jacek; Bryszewska, Maria

doi:10.1016/s0009-9120(97)00166-5

Cited by 13 publications

(11 citation statements)

References 36 publications

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“…Additionally, TZ declined Hb%, RBCs count and HCT% significantly as in previous studies 54,55 . These changes may be due to the prevention of red blood cell synthesis via inhibition of erythropoisis in the bone marrow 56 as well as increase fragility and progressive destruction of RBCs due to binding of free radicals produced by TZ 57 .…”

Section: Discussionsupporting

confidence: 81%

Quercetin Nanoparticles Repressed Liver and Brain Toxicities Induced by Tartrazine in Rats

Eman

Ibrahim

Hassan

et al. 2018

J. Drug Delivery Ther.

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Tartrazine (TZ) is an azobenzene artificial yellow dye for foods, drugs, and cosmetics. Quercetin is member of the flavonoid family. The current study investigated the protective effect of quercetin nanoparticles (QNPs) against TZ. Male albino rats were divided into group1: control, group 2: TZ (50 mg/kg), group 3: QNPs (5 mg/kg), and group 4: QNPs+TZ. The results of the present study revealed that, the oral administration of TZ dye caused a significantly increased liver biomarkers. Also, a marked effect on lipid profile and blood parameters were shown. In addition TZ induced an elevation in the examined oxidative stress biomarkers and decrease in glutathione peroxidases and acetylcholine esterase. TZ diminished exploration and rearing in open field test as well as elevation in GABA content and apoptosis as well as changes in tissues by histopathological examination. In fact, the results showed good influence of QNPs in improving injuries associated with TZ administration. Keywords: Tartrazine Dye, Quercetin Nanoparticles, Liver-Brain injuries.

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Section: Discussionsupporting

confidence: 81%

Quercetin Nanoparticles Repressed Liver and Brain Toxicities Induced by Tartrazine in Rats

Eman

Ibrahim

Hassan

et al. 2018

J. Drug Delivery Ther.

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“…Studies had shown that RBCs respond to various treatments by various agents by altering their morphological features (Przybylska et al, 1998). A previous study reported that Balbisia peduncularis extract caused changes in the normal erythrocyte morphology observed under an SEM (Suwalsky et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…For morphological examination by a scanning electron microscope (SEM), the procedure by Przybylska et al(1998) was followed with slight modification. RBCs were washed three times by adding 9 portions of 0.1 mol/L sodium-potassium phosphate buffer (pH 7.4) to 1 portion of whole blood, and centrifuged at 3 500 r/min for 20 min.…”

Section: Hematological Studymentioning

confidence: 99%

Toxic effects of Litsea elliptica Blume essential oil on red blood cells of Sprague-Dawley rats

Taib

Budin

Ain

et al. 2009

J. Zhejiang Univ. Sci. B

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Litsea elliptica Blume leaves have been traditionally used as medicinal herbs because of its antimutagenicity, chemopreventative and insecticidal properties. In this study, the toxic effects of L. elliptica essential oil against Sprague-Dawley rat's red blood cells (RBCs) were evaluated. L. elliptica essential oil was given by oral gavage 5 times per week for 3 treated groups in the doses of 125, 250, and 500 mg/(kg body weight), respectively, and the control group received distilled water. Full blood count, RBC osmotic fragility, RBC morphological changes, and RBC membrane lipid were analyzed 28 d after the treatment. Although L. elliptica essential oil administration had significantly different effects on hemoglobin (Hb), mean cell hemoglobin concentration (MCHC), mean cell volume (MCV), and mean cell hemoglobin (MCH) in the experimental groups as compared to the control group (P<0.05), the values were still within the normal range. L. elliptica induced morphological changes of RBC into the form of echinocyte. The percentage of echinocyte increased significantly among the treated groups in a dose-response manner (P<0.001). The concentrations of RBC membrane phospholipids and cholesterol of all treated groups were significantly lower than those of control group (P<0.001). However, the RBC membrane osmotic fragility and total proteins of RBC membrane findings did not differ significantly between control and treated groups (P>0.05). It is concluded that structural changes in the RBC membrane due to L. elliptica essential oil administration did not cause severe membrane damage.

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“…Ch-S is found in relatively large amounts in RBC's where it is known to play a role in osmosis. Its presence induces a change in shape from discoid to echinocytic, caused by the tendency of Ch-S to migrate to the outer membrane layer [267]. An impairment in such deformability due to glycated hemoglobin is associated with diabetes [268].…”

Section: The Role Of Bio-sulfates In Maintaining Cell Membrane Functionmentioning

confidence: 99%

The Initial Common Pathway of Inflammation, Disease, and Sudden Death

Davidson¹,

Seneff²

2012

Entropy

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Abstract:In reviewing the literature pertaining to interfacial water, colloidal stability, and cell membrane function, we are led to propose that a cascade of events that begins with acute exogenous surfactant-induced interfacial water stress can explain the etiology of sudden death syndrome (SDS), as well as many other diseases associated with modern times. A systemic lowering of serum zeta potential mediated by exogenous cationic surfactant administration is the common underlying pathophysiology. The cascade leads to subsequent inflammation, serum sickness, thrombohemorrhagic phenomena, colloidal instability, and ultimately even death. We propose that a sufficient precondition for sudden death is lowered bioavailability of certain endogenous sterol sulfates, sulfated glycolipids, and sulfated glycosaminoglycans, which are essential in maintaining biological equipose, energy metabolism, membrane function, and thermodynamic stability in living organisms. Our literature review provides the basis for the presentation of a novel hypothesis as to the origin of endogenous bio-sulfates which involves energy transduction from sunlight. Our hypothesis is amply supported by a growing body of data showing that parenteral administration of substances that lower serum zeta potential results in kosmotropic cationic and/or chaotropic anionic interfacial water stress, and the resulting cascade.Keywords: inflammation; serum sickness; colloidal instability; interfacial water stress; bio-sulfates; Shwartzman phenomena; sudden death syndrome Glossary of TermsAnaphylaxis a severe, rapidly progressing, life-threatening, generalized allergic reaction. Biological equipoise a stable, non-equilibrium, dissipative system synonymous with life. Cholesterol sulfate (Ch-S)quantitatively the most important known sterol sulfate in human plasma where it regulates the activity of the serine proteases, in cell membranes where it has a stabilizing role, and in platelet membranes where it supports platelet adhesion. Coherence domain (CD)a water CD is a collection of liquid water molecules which oscillate in unison in tune with a self-trapped electromagnetic field at a well-defined frequency. The coherent oscillations produce an ensemble of quasi-free electrons, able to collect noise energy from the environment and transform it into high-grade coherent energy in the form of electron vortices. This high-grade energy may then activate biomolecules resonating with the water CD. Colloidal instabilitya property attributed to a colloidal suspension that develops when stabilizing repulsive steric and electrostatic forces between colliding particles are insufficient to prevent their natural tendency to aggregate into masses large enough to precipitate.Colloidal suspension a colloid that has a continuous liquid phase in which a solid is suspended in a liquid, e.g., our flowing blood. Exclusion zone (EZ)a glass-like, gel phase consisting of water CDs resonating in-phase, adjacent to hydrophilic surfaces, several hundred micrometers wide which excludes colloi...

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Morphological Changes of Human Erythrocytes Induced by Cholesterol Sulphate

Cited by 13 publications

References 36 publications

Quercetin Nanoparticles Repressed Liver and Brain Toxicities Induced by Tartrazine in Rats

Quercetin Nanoparticles Repressed Liver and Brain Toxicities Induced by Tartrazine in Rats

Toxic effects of Litsea elliptica Blume essential oil on red blood cells of Sprague-Dawley rats

The Initial Common Pathway of Inflammation, Disease, and Sudden Death

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