Morphological changes of skeletal muscle, tendon and periosteum in the senescence-accelerated mouse (SAMP6): A murine model for senile osteoporosis

Chen, H.; Yao, Xianfeng; Emura, S.; Shoumura, Shízuko

doi:10.1016/j.tice.2006.08.001

Cited by 19 publications

(15 citation statements)

References 15 publications

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“…However, in support of our findings, a study of older women aged 65–85 undergoing hip arthroplasty showed that there was a preferential type II fibre atrophy in skeletal muscle obtained from the vastus lateralis as well as a significant negative correlation between increased proportion of type II fibre atrophy and BMD [23]. Furthermore, in a mouse model (SAMP 6 phenotype) of senile osteoporosis, soleus muscle type I and type II fibres exhibited significant atrophy [22]. Satellite cells are quiescent unipotent stem cells that have the ability to differentiate into myogenic cell lineage in response to muscle injury [46, 47].…”

Section: Discussionsupporting

confidence: 78%

Muscle Mass, Muscle Morphology and Bone Health Among Community-Dwelling Older Men: Findings from the Hertfordshire Sarcopenia Study (HSS)

et al. 2018

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Sarcopenia and osteoporosis are associated with poor health outcomes in older people. Relationships between muscle and bone have typically been reported at a functional or macroscopic level. The aims of this study were to describe the relationships between muscle morphology and bone health among participants of the Hertfordshire Sarcopenia Study (HSS). 105 older men, mean age 72.5 (SD 2.5) years, were recruited into the HSS. Whole body lean mass as well as appendicular lean mass, lumbar spine and femoral neck bone mineral content (BMC) and bone mineral density (BMD) were obtained through dual-energy X-ray absorptiometry scanning. Percutaneous biopsy of the vastus lateralis was performed successfully in 99 participants. Image analysis was used to determine the muscle morphology variables of slow-twitch (type I) and fast-twitch (type II) myofibre area, myofibre density, capillary and satellite cell (SC) density. There were strong relationships between whole and appendicular lean body mass in relation to femoral neck BMC and BMD (r ≥ 0.43, p < 0.001). Type II fibre area was associated with both femoral neck BMC (r = 0.27, p = 0.01) and BMD (r = 0.26, p = 0.01) with relationships robust to adjustment for age and height. In unadjusted analysis, SC density was associated with whole body area (r = 0.30, p = 0.011) and both BMC (r = 0.26, p = 0.031) and area (r = 0.29, p = 0.017) of the femoral neck. We have demonstrated associations between BMC and changes in muscle at a cellular level predominantly involving type II myofibres. Interventions targeted at improving muscle mass, function and quality may improve overall musculoskeletal health. Larger studies that include women are needed to explore these relationships further.

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Section: Discussionsupporting

confidence: 78%

Muscle Mass, Muscle Morphology and Bone Health Among Community-Dwelling Older Men: Findings from the Hertfordshire Sarcopenia Study (HSS)

et al. 2018

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“…The OVX-SAMP8 mice used in our study differ from the previously described SAMP6 animal model (32,33). In the SAMP6 study, transplantation of allogeneic bone marrow cells from normal mouse strains into osteoporotic SAMP6 mice restored the bone architecture (34).…”

Section: Discussionmentioning

confidence: 91%

Transplantation of Embryonic Fibroblasts Treated with Platelet-Rich Plasma Induces Osteogenesis in SAMP8 Mice Monitored by Molecular Imaging

Chiou²,

Gelovani

et al. 2009

J Nucl Med

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The aim of this study was to develop a cell-based boneregeneration approach evaluated by molecular imaging and immunohistochemistry. Methods: Genetically modified NIH3T3 embryonic fibroblasts carrying enhanced green fluorescent protein (NIH3T3-G) were predifferentiated into osteoblastlike cells using platelet-rich plasma (PRP) medium, followed by intraosseous transplantation into ovariectomized senescenceaccelerated mouse prone substrain 8 (OVX-SAMP8 mice). Results: PRP-conditioned NIH3T3-G (PRP/NIH3T3-G) engraftment prevented the development of osteoporosis. Molecular imaging and immunohistochemistry demonstrated the migration of NIH3T3-G cells from the implantation site throughout the skeleton. In situ analyses revealed coexpression of osteopontin and green fluorescent protein in the newly formed bone tissue, demonstrating that the transplant restored the bone trabecular architecture and mineral density in treated OVX-SAMP8 mice. Interestingly, the life span of OVX-SAMP8 mice receiving PRP/ NIH3T3-G transplantation was significantly prolonged and similar to that of the congenic senescence-resistant strain of mice. Conclusion: This unique and yet simple approach could potentially be applied to the treatment of senile postmenopausal osteoporosis and perhaps inborn genetic syndromes associated with accelerated aging, such as Hutchinson-Gilford progeria syndrome, and for the prolongation of life expectancy in general.

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“…We used the senescence-accelerated mouse prone 6 (SAMP6) model, which is the animal model used to study age-related adaptations in the neuromuscular system [11]. Compared with senescenceresistant inbred strains (SAMR), the median survival time of SAMP6 is 40 % shorter [12], the cross-section area of the soleus muscle is smaller [13], and the body weight is higher [14]. In this study, we compared the effects of casein, whey protein, and whey peptide as the sources of dietary protein in the diets of SAMP6 mice.…”

Section: Introductionmentioning

confidence: 99%

Whey peptide ingestion suppresses body fat accumulation in senescence-accelerated mouse prone 6 (SAMP6)

et al. 2014

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Morphological changes of skeletal muscle, tendon and periosteum in the senescence-accelerated mouse (SAMP6): A murine model for senile osteoporosis

Cited by 19 publications

References 15 publications

Muscle Mass, Muscle Morphology and Bone Health Among Community-Dwelling Older Men: Findings from the Hertfordshire Sarcopenia Study (HSS)

Muscle Mass, Muscle Morphology and Bone Health Among Community-Dwelling Older Men: Findings from the Hertfordshire Sarcopenia Study (HSS)

Transplantation of Embryonic Fibroblasts Treated with Platelet-Rich Plasma Induces Osteogenesis in SAMP8 Mice Monitored by Molecular Imaging

Whey peptide ingestion suppresses body fat accumulation in senescence-accelerated mouse prone 6 (SAMP6)

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