Morphological characteristics of renal changes in Fabry disease

Lerner, Yu V; Tsoy, Larisa V.; Grishina, A. N.; Varshavsky, V A

doi:10.17116/patol20228401121

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…The tendency to overestimate health-related risks from low-dose low-rate exposures to ionizing radiation in publications from the former SU has been noticed in Chernobyl-related studies since the 1990 [42][43][44] and in those from the Urals since the mid-2000s [12,13,[25][26][27][28][29][30] ; commented previously [2,3,11,[45][46][47] . Earlier data by the same and other Russian researchers did not confirm associations of cataracts with doses ≤ 2-4 Gy [48][49][50][51] .…”

Section: Discussionmentioning

confidence: 99%

Exaggeration of consequences of low-dose radiation exposures with special reference to cataracts

Jargin

2024

Imaging. Radiat. Res.

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Publications overestimating the medical and ecological sequels of a slight anthropogenic increase in the radiation background have been reviewed recently with examples of different organs and pathological conditions. The overestimation contributed to the strangulation of atomic energy. The use of nuclear energy for electricity production is on the agenda today due to the increasing energy needs of humankind. Apparently, certain scientific writers acted in the interests of fossil fuel producers. Health risks and environmental damage are maximal for coal and oil, lower for natural gas, and much lower for atomic energy. This letter is an addition to previously published materials, this time focused on studies of cataracts in radiation-exposed populations in Russia. Selection and self-selection bias are of particular significance. Apparently, the self-reporting rate correlates with dose estimates and/or with professional awareness about radiation-related risks among nuclear workers or radiologic technologists, the latter being associated with their work experience/duration and hence with the accumulated dose. Individuals informed of their higher doses would more often seek medical advice and receive more attention from medics. As a result, lens opacities are diagnosed in exposed people earlier than in the general population. This explains dose-effect correlations proven for the incidence of cataracts but not for the frequency of cataract surgeries. Along the same lines, various pathological conditions are more often detected in exposed people. Ideological bias and the trimming of statistics have not been unusual in the Russian medical sciences. It is known that ionizing radiation causes cataracts; however, threshold levels associated with risks are understudied. In particular, thresholds for chronic and fractionated exposures are uncertain and may be underestimated.

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Section: Discussionmentioning

confidence: 99%

Exaggeration of consequences of low-dose radiation exposures with special reference to cataracts

Jargin

2024

Imaging. Radiat. Res.

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Urinary complement proteins in IgA nephropathy progression from a relative quantitative proteomic analysis

Niu

Zhang

Shao

et al. 2023

PeerJ

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Aim IgA nephropathy (IgAN) is one of the leading causes of end-stage renal disease (ESRD). Urine testing is a non-invasive way to track the biomarkers used for measuring renal injury. This study aimed to analyse urinary complement proteins during IgAN progression using quantitative proteomics. Methods In the discovery phase, we analysed 22 IgAN patients who were divided into three groups (IgAN 1-3) according to their estimated glomerular filtration rate (eGFR). Eight patients with primary membranous nephropathy (pMN) were used as controls. Isobaric tags for relative and absolute quantitation (iTRAQ) labelling, coupled with liquid chromatography-tandem mass spectrometry, was used to analyse global urinary protein expression. In the validation phase, western blotting and parallel reaction monitoring (PRM) were used to verify the iTRAQ results in an independent cohort (N = 64). Results In the discovery phase, 747 proteins were identified in the urine of IgAN and pMN patients. There were different urine protein profiles in IgAN and pMN patients, and the bioinformatics analysis revealed that the complement and coagulation pathways were most activated. We identified a total of 27 urinary complement proteins related to IgAN. The relative abundance of C3, the membrane attack complex (MAC), the complement regulatory proteins of the alternative pathway (AP), and MBL (mannose-binding lectin) and MASP1 (MBL associated serine protease 2) in the lectin pathway (LP) increased during IgAN progression. This was especially true for MAC, which was found to be involved prominently in disease progression. Alpha-N-acetylglucosaminidase (NAGLU) and α-galactosidase A (GLA) were validated by western blot and the results were consistent with the iTRAQ results. Ten proteins were validated in a PRM analysis, and these results were also consistent with the iTRAQ results. Complement factor B (CFB) and complement component C8 alpha chain (C8A) both increased with the progression of IgAN. The combination of CFB and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) also showed potential as a urinary biomarker for monitoring IgAN development. Conclusion There were abundant complement components in the urine of IgAN patients, indicating that the activation of AP and LP is involved in IgAN progression. Urinary complement proteins may be used as biomarkers for evaluating IgAN progression in the future.

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Morphological characteristics of renal changes in Fabry disease

Cited by 2 publications

References 17 publications

Exaggeration of consequences of low-dose radiation exposures with special reference to cataracts

Exaggeration of consequences of low-dose radiation exposures with special reference to cataracts

Urinary complement proteins in IgA nephropathy progression from a relative quantitative proteomic analysis

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