Morphological evaluation of the protective role of dark soy sauce against acrylamide induced neurotoxicity in albino rats

Abdelall, H. F.; ElGhamrawy, T. A.; Helmy, Dina Omar

doi:10.5603/fm.2015.0004

Cited by 4 publications

(4 citation statements)

References 31 publications

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“…In accordance with our findings, Lai et al 12 found that ACR exerts toxic effects on the growth and development of hippocampal neurons. Abdelall et al 11 showed shrunken Purkinje cells and nuclear pyknosis in the cerebellum form ACR-treated rats. Dortaj et al 31 reported a lower number of Purkinje cells in rats' infants obtained from ACR-treated mothers.…”

Section: Discussionmentioning

confidence: 97%

“…Moreover, ACR induces direct toxic effects on neuronal cells both in vitro and in vivo. For example, Mehri et al 10 showed that ACR decreases the viability of PC12 cells and Abdelall et al 11 and Lai et al 12 reported progressive degeneration of Purkinje cells and hippocampal neurons by ACR in rats, respectively. ACR was also reported to affect reproductive organs 13 .…”

Section: Introductionmentioning

confidence: 99%

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Minocycline protects against acrylamide-induced neurotoxicity and testicular damage in Sprague-Dawley rats

et al. 2020

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This study investigated the protective effects of minocycline against acrylamide (ACR)-induced neurotoxicity and testicular damage in Sprague-Dawley rats. Forty rats were divided into five groups (eight rats each). Group I received saline (0.5 mL/rat) daily for 10 days and served as the untreated control group. Group II received ACR (30 mg/kg body weight (b.w.)) daily for 10 days. Group III received ACR (30 mg/kg b.w.) daily for 10 days and subsequently minocycline (60 mg/kg b.w.) for five days. Group IV received ACR (30 mg/kg b.w.) daily for 10 days followed by saline for five days and served as the control group for the ACR-minocycline-treated group. Group V received minocycline (60 mg/kg b.w.) for five days. All treatments were administered orally. Rats in group I and V showed normal locomotor behavior and normal histology of the brain and testes. Administration of ACR (Group II and IV) resulted in weight loss and gait abnormalities. Furthermore, neuronal degeneration in the hippocampus and cerebellum and degeneration of the seminiferous tubular epithelium with formation of spermatid giant cells were observed. Ultrastructurally, ACR specifically damaged spermatogonia and spermatocytes. Acrylamide was also seen to cause a significant increase of malondialdehyde levels in the brain and testes. Treatment of ACR-administered rats with minocycline (Group III) significantly alleviated the loss of body weight and improved locomotor function. Minocycline also ameliorated neuronal degeneration and seminiferous tubular damage and decreased malondialdehyde concentrations. In conclusion, minocycline protects against neurotoxic effects of acrylamide and seminiferous tubular damage. Decreasing lipid peroxidation by minocycline might play a role in such protection.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Minocycline protects against acrylamide-induced neurotoxicity and testicular damage in Sprague-Dawley rats

et al. 2020

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“…Li et al [12] found that ACR was efficient in producing crucial Parkinsonian-like pathology including dopaminergic damage and α-synuclein aggregation in C. elegans. In animal models, Abdelall et al [1] and Lai et al [10] reported ACR-induced progressive degeneration of Purkinje cells and hippocampal neurons in rats, respectively. Incubation of cultures with similar concentrations of ACR for 24 h did not significantly affect the number of dopaminergic neurons.…”

Section: Discussionmentioning

confidence: 99%

“…A direct toxic effect of acrylamide was also reported on neuronal cells both in in vitro and in vivo. For example, Mehri et al [16] showed that ACR decreased cell viability of PC12 cells, and Abdelall et al [1] and Lai et al [10] reported progressive degeneration of Purkinje cells and hippocampal neurons by ACR in rats, respectively.…”

Section: Introductionmentioning

confidence: 99%

Neurotoxic effects of acrylamide on dopaminergic neurons in primary mesencephalic cell culture

Radad

Al‐Shraim

Al-Emam

et al. 2019

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Introduction: Exposure to acrylamide is increasing worldwide as a result of its heavy use in industry and formation in carbohydrate-rich food cooked at high temperature. Despite its neurotoxicity, no studies have shown its toxic effects on dopaminergic neurons yet. Therefore, the current study was carried out to show whether acrylamide adversely affects primary cultured dopaminergic neurons. Material and methods: Acrylamide (0.001, 0.01, 0.1, 1, 2 mM) was added to two different groups of primary mesencephalic cell cultures on the 9 th day in vitro for 24 and 48 h, respectively. Moreover, a group of cultures was treated with lower concentrations of acrylamide (0.01, 0.05, 0.1, 0.5 mM) on the 6 th day in vitro for 5 consecutive days to investigate its long-term effects on dopaminergic neurons. Following each treatment, culture media were obtained for measuring lactate dehydrogenase, and cultured cells were stained immunocytochemically against tyrosine hydroxylase and neuronal nuclear antigens. Results: Treatment of cultures with acrylamide for 48 h significantly reduced the number of dopaminergic neurons, adversely altered the morphology of the surviving neurons and increased levels of lactate dehydrogenase in the culture media. Similar treatment of cultures with acrylamide also resulted in lower numbers of total neuronal cells as shown by a reduced expression of the neuronal nuclear antigen. Prolonged treatment of cultures with lower concentrations of acrylamide slightly reduced the survival of dopaminergic neurons but increased the release of lactate dehydrogenase into the culture media as well. Conclusions: The current study shows, for the first time, neurotoxicity of acrylamide on dopaminergic neurons in the primary mesencephalic cell culture.

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Tempeh and Other Fermented Soybean Products Rich in Isoflavones

Mani

Ming

2017

Fermented Foods in Health and Disease Prevention

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Morphological evaluation of the protective role of dark soy sauce against acrylamide induced neurotoxicity in albino rats

Cited by 4 publications

References 31 publications

Minocycline protects against acrylamide-induced neurotoxicity and testicular damage in Sprague-Dawley rats

Minocycline protects against acrylamide-induced neurotoxicity and testicular damage in Sprague-Dawley rats

Neurotoxic effects of acrylamide on dopaminergic neurons in primary mesencephalic cell culture

Tempeh and Other Fermented Soybean Products Rich in Isoflavones

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