Morphological Features and Effects on Reproductive Parameters of Ovarian Cysts of Follicular Origin in Superovulated Rabbit Does

López-Béjar, Manel; López‐Gatius, F.; Camón, J.; Rutllant, J.; Valls, Xavier Binefa i; Labèrnia, J.; Santolaria, P.

doi:10.1111/j.1439-0531.1998.tb01374.x

Cited by 4 publications

(1 citation statement)

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“…Introduction Follicular cysts have been reported in many mammalian species, including cattle (Roberts 1971, Kesler & Garverick 1982, swine (Heinonen et al 1998), dogs (Arbeiter 1993, rabbits (Lopez-Bejar et al 1998), rats (Brawer et al 1986), mares (McCue & Squires 2002), sheep (Christman et al 2000), elephants (Brown et al 1999) and women (Stein & Leventhal 1935). In cattle, this condition is characterized by large (generally $25 mm in diameter) anovular structures that persist on the ovary for at least 10 days in the absence of a corpus luteum (CL) (Roberts 1971).…”

Section: Reproduction (2005) 129 737-745mentioning

confidence: 99%

Follicular cysts occur after a normal estradiol-induced GnRH/LH surge if the corpus hemorrhagicum is removed

Gümen

Wiltbank²

2005

Reproduction

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The pathophysiology underlying follicular cysts appears to be lack of an estradiol (E 2 )-induced GnRH/LH surge due to hypothalamic insensitivity to E 2 . In addition, progesterone (P 4 ) can cause animals with follicular cysts to resume normal cyclicity and normal hypothalamic responsiveness to E 2 . We postulated that follicular cysts may be a pathological manifestation of a physiological state that cows, and possibly other species, go through during the normal estrous cycle but the rise in P 4 following ovulation induces them back to normal hypothalamic responsiveness to E 2 . Based on this hypothesis, we expected that removal of the ovary containing the corpus hemorrhagicum would prevent the normal rise in P 4 following ovulation and induce development of follicular cysts. Cows (n 5 24) on day 7 of the estrous cycle were treated with prostaglandin F 2a (PGF 2a ) and time of ovulation was detected by ovarian ultrasonography every 8 h. Immediately following detection of ovulation, cows were randomly but unequally assigned to have the ovary containing the corpus hemorrhagicum removed (TRT; n 5 16) or the ovary opposite to the corpus hemorrhagicum removed (CON; n 5 8). Cows were subsequently evaluated by daily ultrasound and blood sampling to determine follicular dynamics. Ovulation was detected at 93.7 6 4.5 h after PGF 2a injection. All CON cows had a normal estrous cycle length (22.0 6 0.6 days) after ovariectomy (OVX). Half of the TRT cows became anovular (TRT-ANO; n 5 8) after OVX with large anovular follicles developing on the ovary (maximal size, 25.4 6 1.4 mm; range, 20-32 mm). However, eight TRT cows ovulated (TRT-OV; n 5 8) 7.3 6 0.6 days after OVX. Control cows had a normal P 4 rise after ovulation. Removal of the newly formed corpus hemorrhagicum prevented the rise in circulating serum P 4 in TRT-ANO cows throughout the 25-day experimental period. The TRT-OV cows had a delayed increase in circulating P 4 but it was normal in relation to time of ovulation. Serum E 2 concentrations were similar among groups (TRT-OV, TRT-ANO and CON cows) until 7 days after OVX. Serum E 2 concentrations then decreased in TRT-OV and CON cows but remained elevated (> 5 pg/ml) in TRT-ANO cows. Thus, the endogenous increase in circulating E 2 that induces the GnRH/LH surge and estrus is sufficient to induce cows into a physiological state that resembles follicular cysts if it is not followed by increased circulating P 4 . Reproduction (2005) 129 737-745Introduction Follicular cysts have been reported in many mammalian species, including cattle (Roberts 1971, Kesler & Garverick 1982, swine (Heinonen et al. 1998), dogs (Arbeiter 1993, rabbits (Lopez-Bejar et al. 1998), rats (Brawer et al. 1986), mares (McCue & Squires 2002), sheep (Christman et al. 2000), elephants (Brown et al. 1999) and women (Stein & Leventhal 1935). In cattle, this condition is characterized by large (generally $25 mm in diameter) anovular structures that persist on the ovary for at least 10 days in the absence of a corpus luteum (CL) (Roberts 1...

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Section: Reproduction (2005) 129 737-745mentioning

confidence: 99%

Follicular cysts occur after a normal estradiol-induced GnRH/LH surge if the corpus hemorrhagicum is removed

Gümen

Wiltbank²

2005

Reproduction

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Ovarian response and embryo gene expression patterns after nonsuperovulatory gonadotropin stimulation in primiparous rabbits does

Álvarez¹,

García-García²,

Rebollar³

et al. 2013

Theriogenology

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Temperature gradients in vivo influence maturing male and female gametes in mammals: evidence from the cow

Hunter

López‐Gatius

López-Albors

2017

Reprod. Fertil. Dev.

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Since 1980 several reports have indicated that temperatures vary between preovulatory follicles and other ovarian tissues in rabbit, cow, pig and human. However, these observations did not achieve prominence; they were regarded as artefacts due to the use of anaesthetics and open surgery (laparotomy). Recently, without resorting to anaesthesia or surgery, direct measurements of temperature in preovulatory follicles have been performed in the cow by means of a thermistor probe introduced into the antrum under ultrasonic guidance. Such follicles revealed a mean antral (follicular fluid) temperature 0.74°C and 1.54°C cooler than uterine surface and rectal temperatures respectively in ovulating cows, whereas no such temperature differences were detected in non-ovulating cows. Cows are predominantly monovular and preovulatory follicles attain a diameter of 15-22mm or more. These features and the timescale of response to the preovulatory gonadotrophin surge make them a valuable model for the human preovulatory follicle. Temperature gradients are interpreted primarily in a context of final maturation of gametes immediately before the onset of fertilisation. Preovulatory follicular temperature in women could be assessed by a comparable approach and might become a valuable selection guide for oocyte viability.

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Morphological Features and Effects on Reproductive Parameters of Ovarian Cysts of Follicular Origin in Superovulated Rabbit Does

Cited by 4 publications

References 38 publications

Follicular cysts occur after a normal estradiol-induced GnRH/LH surge if the corpus hemorrhagicum is removed

Follicular cysts occur after a normal estradiol-induced GnRH/LH surge if the corpus hemorrhagicum is removed

Ovarian response and embryo gene expression patterns after nonsuperovulatory gonadotropin stimulation in primiparous rabbits does

Temperature gradients in vivo influence maturing male and female gametes in mammals: evidence from the cow

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