Morphological Modification of Carbon Nanoparticles after Interacting with Methotrexate as a Potential Anticancer Agent

Thangavelu, Muthukumar; Aravinthan, Adithan; Parvathaleswara, Sastry Thotapalli; Chamundeeswari, M.

doi:10.1007/s11095-018-2468-4

Cited by 3 publications

(1 citation statement)

References 40 publications

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“…Duo to their specific properties in size, shape, and chemical composition, nanoparticles presented promising capabilities by surface modification. Drug delivery systems constructed from nanoparticles showed good biocompatibility, hemocompatibility, penetrating, and targeting ability, and thus improved drug efficacy and reduced toxicity [23][24][25]. Some anticancer drugs have obtained approval for clinical use, such as liposomal paclitaxel [26] and Marqibo (vincristine sulfate liposome injection) [27].…”

Section: Discussionmentioning

confidence: 99%

Do carbon nanoparticles really improve thyroid cancer surgery? A retrospective analysis of real-world data

Liu

Wang

et al. 2020

World J Surg Onc

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Background: Parathyroid protection and central neck dissection (CND) are basic points of thyroid cancer surgery and draw persistent concern. We aimed to evaluate the value of carbon nanoparticles (CNs) for parathyroid gland protection and CND in thyroid surgery for thyroid cancer patients. Methods: A total of 386 consecutive thyroid cancer patients were enrolled in the retrospective study. Three hundred thirty-four patients using CNs intraoperatively were included in the CN group, and 52 patients without using CNs or any other helping agent were included in the control group. Intact parathyroid hormone (iPTH) was examined. Medical records and histopathologic reports were reviewed. Histopathologic examination was performed. Results: There were no statistical significances in demographic and basic surgical information, preoperative iPTH, and serum calcium between the two groups (P > 0.05). In the CN group, the thyroid tissue and central neck lymph nodes were stained black by CNs, while the parathyroid glands were not. Histopathological examination showed that the carbon nanoparticles might accumulated in the subcapsular sinus of lymph nodes compared with the none-stained samples. The staining with CNs did not impact the histopathological examination. There were no significant differences in postoperative hypocalcemia and hypoPT at day 1, 1 month, and half year after surgery between the two groups, respectively. There was a big decline of iPTH level after surgery, whereas the perioperative decreasing amplitude of PTH was not statistically different between the CNs and control group (57.2 ± 28.6 vs 55.7 ± 27.8, P = 0.710). There were 43 patients occurring incidental parathyroidectomy in the CN group (43/334, 12.9%) and 7 patients in the control group (7/52, 13.5%), without significant difference (P = 0.907). There was no significant difference in the number of lymph nodes identified by pathology per patient between the CNs and control group regardless of unilateral and bilateral CND.

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Section: Discussionmentioning

confidence: 99%

Do carbon nanoparticles really improve thyroid cancer surgery? A retrospective analysis of real-world data

Liu

Wang

et al. 2020

World J Surg Onc

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Green synthesis and optimization of zinc oxide quantum dots using the Box–Behnken design, with anticancer activity against the MCF-7 cell line

et al. 2022

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A green strategy and cost-effective approach was adapted to prepare Zinc oxide quantum dots (ZnO-QDs) for biomedical applications. The prepared ZnO-QDs may hold great promise as sensing scanners for diagnostics and therapy, as demonstrated in our current study. Zinc Sulphate, Azadirachta indica, and Catharanthus roseus leaves extract were used to synthesis a novel natural Zinc oxide bionanocomposite (ZnO-BC) and used as a precursor to prepare ZnO-QDs by microwave-assisted technique. The ZnO-BC was characterized by SEM-EDX, FTIR, XRD, Zeta potential and particle size analysis. The optical properties of QDs were investigated using UV and PL spectrophotometers. Experimental factors like the concentrations of ZnO-NPs, C. roseus and A. verawere evaluated using Box-Behnken design (BBD). MTT and haemolysis assay was performed using ZnO-BC and ZnO-QDs. Maximum absorbance observed at optimized values of 0.5% ZnO-NPs, 1g A.vera gel and 0.5ml C.roseus leaf extract of ZnO-QDs against BBD. There was decreased viability rate, ranging from 60-15% for 0.5mg/ml ZnO-BC and 45-5% for 5 mg/ml ZnO-QDs which revealed a tenfold decrease in cell viability with less concentration scale for 5mg/ml of ZnO-QDs when compared with that of 0.5 mg/ml ZnO-BC. Also, hemolysis test shows that the hemolysis ratio was below 0.5%, indicating non-haemolysis of ZnO-QDs. cellular morphology by results was supported by phase-contrast microscopy images. A good biocompatibility and high anticancer activity was noticed for ZnO-QDs when compared to ZnO-BC and provide versatile applications in the eld of Nano biomedicine.

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A reign of bio-mass derived carbon with the synergy of energy storage and biomedical applications

Rajkumar

Diwakar

Subadevi

et al. 2022

Journal of Energy Storage

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Morphological Modification of Carbon Nanoparticles after Interacting with Methotrexate as a Potential Anticancer Agent

Abstract: The morphologically modified CNPs has shown good anticancer, biocompatibility and haemocompatibility property which is an important criterion to be satisfied by a biomedical product.

Cited by 3 publications

References 40 publications

Do carbon nanoparticles really improve thyroid cancer surgery? A retrospective analysis of real-world data

Do carbon nanoparticles really improve thyroid cancer surgery? A retrospective analysis of real-world data

Green synthesis and optimization of zinc oxide quantum dots using the Box–Behnken design, with anticancer activity against the MCF-7 cell line

A reign of bio-mass derived carbon with the synergy of energy storage and biomedical applications

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