Morphological Profiles of Neutron and X-Irradiated Small Intestine.

Abstract

This paper describes the response of mouse small intestine, at several time points after treatment with neutron or X-irradiation, using doses expected to give similar effects in terms of crypt/microcolony survival. Using resin histology, the effects of radiation on the numbers of duodenal cell types and measurements of tissue areas were assessed. The results for individual parameters and for an estimate of overall damage are given in a data display, which summarises the morphological profile of the organ after both types of radiation. Damage and recovery were seen for many of the parameters studied but there was no standard response pattern applicable for all parameters. In particular, the response of individual crypt cell types could not be predicted from knowledge of the change in crypt numbers. With regard to the holistic response of the gut, neutron irradiation appeared to have caused more damage and produced more early effects than the X-irradiation. More specifically, neutron treatment led to more damage to the neuromuscular components of the wall, while X-irradiation produced early vascular changes.

Radioprotective effect of sugar cane extract in chickens

“…Leucocytic infiltration in and around the affected crypts was occasionally shown, indicating that these cells suffered from severe pycnotic changes. These results are highly in agreement with those obtained from other experimental models (Carr et al, 1996). Moreover the lumen of many crypts became conspicuous, accompanied with extreme squamation of the lining epithelium.…”

Genome-Wide Expression Changes in Saccharomyces cerevisiae in Response to High-LET Ionizing Radiation

“…Two genes involved in cell wall function (ECM4 and SPI1) have been associated with toxin resistance and acid stress. It has also been reported that neutron irradiation causes more damage to the cell wall and produces more early effects than X-ray treatment of the intestinal wall of mice [56].…”

Alterations of the VIP-stimulated cAMP pathway in rat distal colon after abdominal irradiation

“…Nevertheless, this small 25% reduction of the cell number may concern an important number of secretory cells, leading to a significant loss of secretory response. Indeed, the proportion of cryptal cells of different types has been shown to vary differently after an irradiation (8). The hyporesponsiveness to VIP is transitory, because I sc responses returned to normal values at 7 days after exposure.…”