Radioprotective effect of sugar cane extract in chickens

Abstract

To evaluate the radioprotective effect of sugar cane extract (SCE), SCE was orally administered into the crop of 3-week-old chickens for 3 consecutive days before or after x-ray radiation at a dose of 500 mg/kg/day. The survival rate of SCE administered chickens before x-ray radiation at a dose of 920 rad increased to 68.8% when compared with that of the irradiated control (50%). Histopathological examination revealed the intestine of SCE administered chickens to have mild to moderate pathological changes, when compared with that of the irradiated control animals.

Reduced Lipopolysaccharide (LPS)-Induced Nitric Oxide Production in Peritoneal Macrophages and Inhibited LPS-Induced Lethal Shock in Mice by a Sugar Cane (Saccharum officinarumL.) Extract

“…In addition, it has been reported to have many biological activities in chickens orally administered SCE. [4][5][6][7][8][9] The present results demonstrate that SCE prevented lethal shock in mice challenged with LPS+GalN. This protective effect was observed with a peritoneal injection of SCE, but not in the mice receiving either an oral administration or intravenous injection of SCE.…”

“…3) We have also demonstrated that our sugar cane extract (SCE) had an adjuvant effect on the activation of antibody and cell-mediated immune responses, 4,5) a protective effect against Eimeria tenella infection, 6) a radioprotective effect on immune functions and intestinal damage in X-ray irradiated chickens, 7,8) and a reconstituting effect on the bursa-dependent immune system in the immunosuppression experimentally induced by injecting cyclophosphamide into chickens. 9) Tumor necrosis factor (TNF)-induces various biological responses including tissue injury, shock and apoptosis.…”

Protective effects of sugar cane extract on endotoxic shock in mice

“…Previous studies in the chicken demonstrated that oral administration of SCE resulted in an increase in immune responses including antibody production and delayed type hypersensitivity (El-Abasy et al, 2002;ElAbasy et al, 2003a;El-Abasy et al, 2003b;Amer et al, 2004;Amer et al, 2005) and the relative proportion of CD4 in the peripheral blood leukocytes (unpublished data). In addition, the phagocytic activities of chicken polymorphonuclear cells were enhanced by the addition of SCE and its polyphenol rich fraction (approximately 25%) in vitro (El-Abasy et al, 2002).…”

“…SCE was kindly provided by Mitsui Sugar Co. Ltd, Japan. Original materials including El-Abasy et al, 2003a;Amer et al, 2004;Amer et al, 2005), as shown in Table 1. In addition, the relative content of polyphenol in the SCE was 4.27%, and the concentration of LPS in the SCE solution was less than 0.05 ng/mL when determined by the limulus test (Prior and Spagna, 1983).…”

“…It was found that green tea (Yang et al, 1998;He et al, 2001) and flavonoids such as wogonin (Van Dien et al, 2001) or naringin (Kawaguchi et al, 1999) possess protective effects against LPS-induced lethal shock in d-galactosamine (GalN)-sensitized mice by suppressing TNF-α production. It has been reported that sugar cane extract (SCE), one of the natural byproducts of the sugar cane industry, has enhancing effects on the immune responses in normal chickens (El-Abasy et al, 2002;El-Abasy et al, 2003a) and in immunosuppressed chickens injected with cyclophosphamide or exposed to x-ray irradiation (Amer et al, 2004;Amer et al, 2005). Furthermore, it was found that the SCE has protective effects on Eimeria tenella infection in chickens (ElAbasy et al, 2003b).…”