Morphological transitions of micelles induced by the block arrangements of copolymer blocks: dissipative particle dynamics simulation

Abstract

Polymer micelles with distinct morphologies and unique microphase separation microstructures can exhibit different properties and functions, holding the great promises for a range of biomedical applications. In current work, the...

Multicompartment colloid systems with lipid and polymer membranes for biomedical applications

“…Block copolymers undergo microphase separation in bulk and tend toward the self-assembly in solution and the formation of internally ordered microparticles. 185,186 Common block copolymers undergo microphase separation in selective solvents to form micelles. If A is a solvophilic block, an AB diblock copolymer in a selective solvent for the A block is self-organized in spherical micelles, worm-like micelles or vesicles.…”

Folate modified dual pH/reduction-responsive mixed micelles assembled using FA-PEG-PDEAEMA and PEG-SS-PCL for doxorubicin delivery

“…Since computational simulations have been demonstrated to be a powerful support and supplement for experimental systems, in this work, dissipative particle dynamics (DPD) simulations, a mesoscopic stochastic coarse-grained method proposed by Hoogerbrugge and Koelman in 1992 34 suitable for complex multiphase systems, was employed to optimize the molecular structure of the polymers and the drug-loading proportion of the mixed micelles, [35][36][37][38] as well as to investigate the relationship between the mesoscopic structure and macroscopic properties of the drug-loaded mixed polymeric micelles. Then, the target polymers PEG-PDEAEMA, FA-PEG-PDEAEMA and PEG-SS-PCL were experimentally synthesized and characterized, and their mixed micelles were applied for doxorubicin (DOX) delivery.…”