Morphology and radio-opaque lines in bones of foetal lambs: The effects of maternal nutrition

Spence, J.A.; Aitchison, G.U.

doi:10.1016/0021-9975(82)90091-3

Cited by 11 publications

(3 citation statements)

References 14 publications

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“…The length between the radial metaphyses was measured on lateral radiographs of isolated limbs by the method of Spence et al (24). The same approach was used to measure tibia, metacarpals, and metatarsals; the distance between the midpoints of the proximal and distal metaphyses was measured.…”

Section: Bone Lengthsmentioning

confidence: 99%

Effect of Hypophysectomy with and without Thyroxine Replacement on Growth and Circulating Concentrations of Insulin-Like Growth Factors I and II in the Fetal Lamb*

et al. 1987

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The role of the pituitary gland in the regulation of skeletal growth and plasma insulin-like growth factor (IGF)-I and IGF-II concentrations in the late gestation sheep fetus has been studied. Singleton fetuses were either hypophysectomized (n = 14) or sham operated (n = 8) between days 110 and 125. Fetal and maternal blood samples were collected three times weekly through the remainder of gestation. In some hypophysectomized fetuses (HXT4 group, n = 4), T4 was administered (100 micrograms L-T4/day) to overcome the hypothyroidism caused by hypophysectomy. The other hypophysectomized fetuses received no replacement therapy (HXNR group, n = 10). Six HXNR fetuses were allowed to remain in utero post term and were killed at day 163 of gestation. All other animals were killed at day 147. All values are group means +/- SE. Hypophysectomized fetuses had significantly shorter limbs and long bones and delayed osseous maturation at term compared to sham controls. Plasma free T4 concentrations in HXT4 fetuses were not significantly different from those measured in sham fetuses (P greater than 0.05). Bone maturation at term was normal in HXT4 fetuses although there was no improvement in limb or bone elongation. Retention of hypophysectomized fetuses in utero until 16 days past term yielded fetuses which were heavier than controls but whose limb and bone lengths were no greater than hypophysectomized fetuses killed at term. Osseous maturation was appropriate for term in five of the six postterm hypophysectomized fetuses. The plasma IGF-I and IGF-II concentrations were not significantly affected by hypophysectomy, hypophysectomy with T4 replacement, gestational age, or prolonged gestation. The plasma IGF-I concentrations in the sham, HXNR, and HXT4 fetuses were 35.4 +/- 6.6, 28.2 +/- 3.0, and 34.4 +/- 1.7 ngeq human (h)IGF-I/ml, and the IGF-II concentrations were 656.3 +/- 59.2, 635.3 +/- 56.3, and 645.5 +/- 71.9 ngeq hIGF-II/ml, respectively, and remained within these ranges throughout the experiment. Fetal IGF-I concentrations were significantly lower than mean maternal IGF-I concentrations (88.0 +/- 6.8 ngeq hIGF-I/ml, P less than 0.05), and fetal IGF-II concentrations were significantly higher than mean maternal IGF-II concentrations (362.4 +/- 24.0 ngeq hIGF-II/ml, P less than 0.05). We conclude that in the late gestation fetal sheep, elongation of the appendicular skeleton is under some direct pituitary control whereas appendicular maturation exhibits some dependence on circulating T4 concentrations.(ABSTRACT TRUNCATED AT 400 WORDS)

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Section: Bone Lengthsmentioning

confidence: 99%

Effect of Hypophysectomy with and without Thyroxine Replacement on Growth and Circulating Concentrations of Insulin-Like Growth Factors I and II in the Fetal Lamb*

et al. 1987

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“…Spence et al [8] report a method of assessing fetal growth in utero by injection of oxytetracycline hydrochloride directly into the sheep fetus. Necroscopic studies of trabecular bone were used to determine rates of bone mineralization.…”

Section: Discussionmentioning

confidence: 99%

Fetal Metatarsal Length: An Accurate Predictor of Gestational Age and Weight in the Ovine Fetus

Santucci

Kuller

Battelli

et al. 1993

Gynecol Obstet Invest

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Accurate assessment of gestational age and fetal weight in the pregnant ewe is important in both acute and longitudinal perinatal studies. We describe two morphometric methods based on the length of the fetal metatarsal bone. These measurements can be made intraoperatively or at postmortem. Metatarsal bone lengths can be used to better predict gestational age and fetal weight than previously described methods.

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“…Eine Erweichung derKnochenstrukturen und die konsekutive Ve rbiegung derR öhrenknochen prägend as klinische Bildd er Rachitis.B egründetl iegt diese Erkrankung in einern icht ausgewogenen Fütterung beie inem relativenMangelanKalzium, anorganischemPhosphatund Vitamin D 3 (9,11). DieEpiphysiolysis beiälterenSchaflämmern entsteht durchaseptischeNekrosen desFugenknorpels aufgrund akzelerierten Wachstums beirascher Gewichtszunahme (23,28).…”

Section: Introductionunclassified

Bericht über das Auftreten einer hereditären Chondrodysplasie bei Jungschafen (Spider Lamb Syndrome)

Seidel¹,

Köhler²,

Hecht³

et al. 2006

Tierarztl Prax Ausg G

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Zusammenfassung Gegenstand und Ziel: Bei neonatalen Lämmern und Jungtieren einer Herde von Suffolk-Schafen traten plötzlich progressive skelettale Anomalien auf. Ziel dieser Untersuchung war, klinische und genetische Nachweise auf das Vorliegen einer hereditären Chondrodysplasie bei den Jungtieren durchzuführen. Falldarstellung: Vier betroffene Jungtiere, ein weibliches und drei männliche Lämmer im Alter von zwei bis vier Monaten, wurden zur Abklärung des Krankheitsgeschehens näher untersucht. Ergebnisse: Die Befunde der klinischen und röntgenologischen Untersuchung, die histologische Auswertung des unregelmäßigen Wachstums in den Röhrenknochen sowie der genetische Nachweis bestätigten das Vorliegen einer hereditären Chondrodysplasie, des so genannten “Spider Lamb Syndrome”. Klinische Relevanz: In der vorliegenden Arbeit werden die Befunde der klinischen, röntgenologischen, postmortalen und genetischen Untersuchungen präsentiert, der derzeitige Stand der Wissenschaft dokumentiert und die züchterischen Konsequenzen diskutiert.

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Morphology and radio-opaque lines in bones of foetal lambs: The effects of maternal nutrition

Cited by 11 publications

References 14 publications

Effect of Hypophysectomy with and without Thyroxine Replacement on Growth and Circulating Concentrations of Insulin-Like Growth Factors I and II in the Fetal Lamb*

Effect of Hypophysectomy with and without Thyroxine Replacement on Growth and Circulating Concentrations of Insulin-Like Growth Factors I and II in the Fetal Lamb*

Fetal Metatarsal Length: An Accurate Predictor of Gestational Age and Weight in the Ovine Fetus

Bericht über das Auftreten einer hereditären Chondrodysplasie bei Jungschafen (Spider Lamb Syndrome)

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