Morphology Character and Andrographolide Quantifications on Sambiloto  ( Andrographis paniculata (Burm.F.)  Nees)   Karakter Morfologi dan Kuantifikasi Andrografolid Pada Sambiloto ( Andrographis paniculata (Burm.F.)  Nees )

Prihatini, Retno; Syarif, Auzar; Bakhtiar, Amri

doi:10.24036/0202041107669-0-00

Cited by 4 publications

(3 citation statements)

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“…Sample calculations were performed before incubation and after incubation for 24 hours. The formula for determining percentage of inhibition can use (Pratiwi et al, 2010):…”

Section: Mic Determinationmentioning

confidence: 99%

Effect of Papaya flower ethanolic extract (Carica Papaya) on the time kill of tetracyclin against Escherichia Coli

Anugraheni,

Rini

2023

Pharmaciana

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Papaya (Carica papaya) is found throughout Indonesia. Papaya flowers contain saponin, tannin, alkaloid, and flavonoid compounds which functions as antibacterial. Escherichia coli is a Gram-negative rod bacteria that could be found in the human large intestine as a cause of diarrhea. The study aimed to determine the effect of papaya flower extract and a combination of papaya flower extract with tetracycline antibiotics using the smallest concentration capable of inhibiting 50% of bacterial growth against Escherichia coli bacteria ATCC 25922 using the time-kill test method. This study used the method of Minimum Inhibitory Concentration (MIC) and time-kill. The MIC of the ethanol extract of papaya flower was 2 mg/mL. The time-kill test showed that the death phase was occurred at 4 -24 hours. The bacteriostatic effect of the extract was obtained at 0 hours to 24 hours, while the antibiotic and its combination with the extracts had a bactericidal effect at 8 hours and 24 hours.

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“…Sample calculations were performed before incubation and after incubation for 24 hours. The formula for determining percentage of inhibition can use (Pratiwi et al, 2010):…”

Section: Mic Determinationmentioning

confidence: 99%

Effect of Papaya flower ethanolic extract (Carica Papaya) on the time kill of tetracyclin against Escherichia Coli

Anugraheni,

Rini

2023

Pharmaciana

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“…Maserasi adalah metode ekstraksi sederhana yang menggunakan pelarut dengan pengadukan berulang dan pengocokan pada suhu kamar. Melakukan tahap maserasi untuk mendapatkan bahan yang dibutuhkan Pratiwi et al (2010) Penelitian ini menggunakan jenis rancangan post test only control grup design, dengan melibatkan enam kelompok perlakuan, termasuk kelompok kontrol awal (Aquadest) dan lima konsentrasi yaitu 0,2%. 0,4%.…”

Section: Hasil Dan Pembahasanunclassified

Test The Effectiveness Of Japanese Papaya Leaf Extract (Cnidoscolus aconitifolius) On Aedes aegypti Larvae Mortality

Ardiansyah,

Nafsi,

Hanum

2023

medicra

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Dengue hemorrhagic fever (DHF) is caused by the dengue virus which is transmitted through the bite of the Aedes aegypti mosquito. Prevention of DHF can be done by using larvicides. Synthetic chemical larvicides are considered to have side effects in long-term use and can cause environmental pollution. So we need an alternative larvicides with natural ingredients from plants, namely Japanese Papaya plants. This study aims to determine the effectiveness of Japanese Papaya (Cnidoscolus aconitifolius) leaf extract on the mortality of Aedes aegypti larvae. This type of research uses an experimental study design. This study used 6 treatments with 4 repetitions consisting of control without treatment, P1 (0.2%), P2 (0.4%), P3 (0.6%), P4 (0.8%), and P5 (1%). Observations were made for 48 hours. From the research results obtained LC50 of 1.095%. The results of statistical tests using One-Way ANOVA showed that there was a significant effect on the mortality of mosquito larvae.

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“…Senyawa aktif saponin yang terkandung pada daun bidara akan lebih banyak dihasilkan jika diekstraksi menggunakan pelarut metanol, karena metanol bersifat polar sehingga akan lebih mudah larut dibandingkan pelarut lain (Suharto et al, 2016). Ekstraksi dengan metode maserasi memiliki kelebihan yaitu terjaminnya zat aktif yang diekstrak tidak akan rusak (Pratiwi, 2010). Pada saat proses perendaman bahan akan terjadi pemecahan dinding sel dan membran sel yang diakibatkan oleh perbedaan tekanan antara luar sel dengan bagian dalam sel sehingga metabolit sekunder yang ada dalam sitoplasma akan pecah dan terlarut pada pelarut organik yang digunakan (Novitasari dan Putri, 2016).…”

Section: Pendahuluanunclassified

Pengaruh Suhu dan Waktu Maserasi terhadap Karakteristik Ekstrak Daun Bidara (Ziziphus mauritiana L.) sebagai Sumber Saponin

Chairunnisa¹,

Wartini²,

Suhendra³

2019

JRMA

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Bidara (Ziziphus mauritiana L.) is one of the most natural ingredients that has the potential as a source of saponins. Saponins can be used as a natural surfactant which can replace the synthesis surfactant. The purposes of this research were to determine the effect of temperature and time of maceration on the characteristics of bidara leaf extract (Ziziphus mauritiana L.) and to obtain the best maceration temperature and time in producing the bidara leaf extract (Ziziphus mauritiana L.) as a source of saponins. This research is using randomized block design with two factors. The first factor is the maceration temperature which consists of 3 levels, namely 29±1°C, 40±2°C, and 50±2°C. The second factor is the maceration time which consists of 3 levels, namely 36 hours, 48 hours, and 60 hours. Each treatment is grouped into 2 based on the time of implementation so obtained 18 units. The results showed that treatment of temperature and maceration time and interaction between the treatment were had very significant on the yield, crude saponins levels, and the height of bidara leaf extract foam (Ziziphus mauritiana L.) as the source of saponins. Temperature of 50±2°C and maceration time of 48 hours is the best treatment to produce bidara leaf extract (Ziziphus mauritiana L.) as a source of saponin with a yield characteristic of 42.59±0.02%, crude saponin levels of 40.84±0.09% and foam height 29.03±0.38 mm. Keywords: Ziziphus mauritiana L., saponins, extraction, temperature, maceration time

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Morphology Character and Andrographolide Quantifications on Sambiloto ( Andrographis paniculata (Burm.F.) Nees) Karakter Morfologi dan Kuantifikasi Andrografolid Pada Sambiloto ( Andrographis paniculata (Burm.F.) Nees )

Cited by 4 publications

References 1 publication

Effect of Papaya flower ethanolic extract (Carica Papaya) on the time kill of tetracyclin against Escherichia Coli

Effect of Papaya flower ethanolic extract (Carica Papaya) on the time kill of tetracyclin against Escherichia Coli

Test The Effectiveness Of Japanese Papaya Leaf Extract (Cnidoscolus aconitifolius) On Aedes aegypti Larvae Mortality

Pengaruh Suhu dan Waktu Maserasi terhadap Karakteristik Ekstrak Daun Bidara (Ziziphus mauritiana L.) sebagai Sumber Saponin

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