Morphology of and visual performance with posterior subcapsular cataract

Vasavada, Abhay R.; Mamidipudi, Praveen R.; Sharma, Preeti

doi:10.1016/j.jcrs.2004.02.076

Cited by 32 publications

(16 citation statements)

References 28 publications

(3 reference statements)

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“…We reported similar observations in an earlier prospective study of 150 consecutive patients with presenile cataract. 34 In the present study, high myopia was also an important risk factor. In the young patients with cataract studied here, it was observed that nuclear sclerosis was the most frequent subgroup of high myopia.…”

Section: Discussionsupporting

confidence: 53%

A study to explore the risk factors for the early onset of cataract in India

Praveen

Shah

Vasavada

et al. 2009

Eye

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Purpose The aim of this study was to identify risk factors for the development of cataract in young patients. Settings The study was undertaken at Iladevi Cataract and IOL Research Centre, Ahmedabad, Gujarat, India. Methods In a clinic-based observational study, 340 consecutive patients in the age group of 30-45 years presenting with nuclear, cortical, posterior subcapsular (PSC), mixed, and posterior polar cataract were prospectively studied. A detailed history regarding sunlight exposure, atopy, diabetes, steroid intake, myopia, glaucoma, and uveitis was elicited. Results The mean age of the patients was 40.2±4.6 years; there were 202 men. The major risk factors were atopy (25.6%), idiopathic (19.1%), high myopia (12.4%), atopy with steroid intake (10.9%), steroid usage (7.4%), sunlight exposure (3.8%), and diabetes mellitus (3.2%). PSC was observed in 53.5% eyes. Multinomial logistic regression revealed that atopy (P ¼ 0.016), steroid usage (P ¼ 0.100), and diabetes mellitus (P ¼ 0.076) documented higher odds for PSC. High myopia (Po0.001) and sunlight exposure (P ¼ 0.003) documented higher odds for nuclear cataract.

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Section: Discussionsupporting

confidence: 53%

A study to explore the risk factors for the early onset of cataract in India

Praveen

Shah

Vasavada

et al. 2009

Eye

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“…51-54 Nonetheless, P remained the third most important contributor to change in visual acuity for the study cohort and the second most important variable in the subset that lost 4 or more letters of acuity. Posterior subcapsular cataracts are located close to the visual axis, and are known for their impact on visual performance.…”

Section: Resultsmentioning

confidence: 92%

“…Posterior subcapsular cataracts are located close to the visual axis, and are known for their impact on visual performance. 51-54 Among all subjects completing the 4 year study gradable P (above the minimum LOCS-III score of 0.1) was found in 26 of 152 subjects on the first visit and 53 of 152 subjects on the final visit, a 104% increase compared to an 18% increase in gradable cortical cataracts (from 121 to 143 subjects).…”

Section: Resultsmentioning

confidence: 98%

Factors Accounting for the 4-Year Change in Acuity in Patients Between 50 and 80 Years

Koenig

Nguyen

Parker

et al. 2013

Optometry and Vision Science

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Purpose It is well known acuity slowly decreases in later decades of life. We wish to determine the extent 4 year longitudinal acuity changes can be accounted for by changes in optical quality, or combination of optical quality metrics and age between 50 and 80. Methods High contrast logMAR acuity, 35 image quality metrics, 4 intraocular scatter metrics, and 4 Lens Opacification Classification System-III metrics and entry age were measured on one eye of each of 148 subjects. Acuity change between baseline and the last visit was regressed against change in each metric for all eyes and a faster changing subset of 50 eyes with a gain or loss of 4 or more letters. Results Average change across 148 subjects was a 1.6 ± 4 letter loss (t148 = 4.31, p < 0.001) and loss for the faster changing subset was 3.4 ± 6.1 letters (t50 = 2.73, p = 0.008). The multiple-regression model for faster changing eyes included change in point spread function entropy, posterior subcapsular cataract, and trefoil and baseline age (sequential r2-adj values 0.19, 0.27, 0.32, 0.34 respectively p = 1.48×10−4 for the full 4 factor model). The same variables entered the multiple-regression model for the full 148 data set where the majority of the acuity measurements were within test re-test error and accounted for less of the variance (r2-adj = 0.15, p = 2.37×10−5). Conclusions Despite being near noise levels for the measurement of acuity, change in optical quality metrics were the most important factors in eyes that lost or gained 4 or more letters of acuity. These findings should be generalizable given our four year acuity change is essentially identical to other studies, and indicate these optical quality markers can be used to help identify those on a faster track to an acuity change.

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“…Our findings of a poor correlation between signs and symptoms are in line with previous cataract studies that compared different variables 26,27 and are consistent with previous research that found that posterior subcapsular cataracts cause disproportionately more visual disability than nuclear or cortical cataracts. 28,29 Vasavada et al 30 found that patients with posterior subcapsular cataracts experience reduced vision and not glare, despite objective glare disability being more common in posterior subcapsular cataracts than nuclear or cortical cataract. 31 Binocularity may be a significant confounder of this relationship because perception of visual symptoms will consist of the complexities of using both eyes together, not just the eye undergoing surgery.…”

Section: Commentmentioning

confidence: 99%