Morphology of collagen matrices for tissue engineering (biocompatibility, biodegradation, tissue response)

Shekhter, Anatoly B.; Guller, Anna; Истранов, Л. П.; Истранова, Е. В.; Butnaru, Denis; Винаров, А.З.; Захаркина, О. Л.; Kurkov, A. V.; Kantimerov, D. F.; Антонов, Е. Н.; Marisov, L V; Glybochko, Petr

doi:10.17116/patol201577629-38

Cited by 19 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Histological and immunohistochemical analysis of heterotopic implants supplemented our understanding of the biocompatibility of tissue engineered constructs at the tissue level. The presence of a thin connective tissue capsule without pronounced fibrosis, the absence of microcirculation and immune disorders suggest that the implanted matrices are biocompatible and non-toxic, which corresponds to the reactions to biocompatible polymer materials described in the literature [3].…”

Section: Resultsmentioning

confidence: 64%

Comparative Morphological Characteristics of the Results of Implantation of Decellularized and Recellularized Porcine Skin Scaffolds

et al. 2021

View full text Add to dashboard Cite

The tissue reaction of pig skin to implantation of decellularized and recellularized dermal matrices on a formed wound defect was evaluated by histological methods on days 2, 5, 8, 16, and 20 after surgery. Differences in tissue response to different matrices were identified. In experimental wounds coated with decellularized dermal matrices, we observed the formation of a scar tissue, which required autodermoplasty on day 12 of the experiment. In wounds coated with recellularized dermal matrices, all layers of the skin completely recovered by day 20 after surgery with the formation of full dermal and epidermal layers. Our findings suggest that reparative morphological changes in the wound depend on the presence of fibroblasts in the implanted dermal matrix.

show abstract

Section: Resultsmentioning

confidence: 64%

Comparative Morphological Characteristics of the Results of Implantation of Decellularized and Recellularized Porcine Skin Scaffolds

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Данный материал обладает низкой антигенностью и стимулирует регенерацию, выполняя роль направляющей матрицы для формирования собственной соединительной ткани пациента, поэтому оптимален для восполнения хронических дефектов мягких тканей при СДС даже в случаях глубоких и извитых раневых каналов, когда аутопластика невозможна [12]. Кроме того, введение биологического материала на основе нативного коллагена в область коррекции приводит к уменьшению активности раневых ММП и обеспечивает ткани основными биологическими ресурсами (натуральным нереконструированным коллагеном с сохраненной волокнистой структурой), который требуется для восстановления разрушенной архитектоники соединительной ткани и заживления ран [8,9,13,14].…”

Section: материалы и методыunclassified

Diabetic foot syndrome. Replacement for inpatient treatment technique based on the fast track surgery

Корейба

MINABUTDINOV²,

Туешев

et al. 2019

Stacionarozameshchayushchie tekhnologii: Ambulatornaya khirurgi

View full text Add to dashboard Cite

“…Scaffolds can be produced using fibrous and porous materials made from synthetic polymers (e.g., polylactate, polycaprolactone, polylactoglycolide) or materials of natural origin (collagen, chitosan, hyaluronic acid) [ 17 ], as well as specially treated natural tissues and organs [ 25 , 26 ]. The major advantage of synthetic scaffolds fabricated by engineering methods (electrospinning, 3D printing, etc.)…”

Section: Tumor Tec Componentsmentioning

confidence: 99%

Bioreactor-Based Tumor Tissue Engineering

Guller

Grebenyuk²,

Shekhter

et al. 2016

Acta Naturae

Self Cite

View full text Add to dashboard Cite

This review focuses on modeling of cancer tumors using tissue engineering technology. Tumor tissue engineering (TTE) is a new method of three-dimensional (3D) simulation of malignant neoplasms. Design and development of complex tissue engineering constructs (TECs) that include cancer cells, cell-bearing scaffolds acting as the extracellular matrix, and other components of the tumor microenvironment is at the core of this approach. Although TECs can be transplanted into laboratory animals, the specific aim of TTE is the most realistic reproduction and long-term maintenance of the simulated tumor properties in vitro for cancer biology research and for the development of new methods of diagnosis and treatment of malignant neoplasms. Successful implementation of this challenging idea depends on bioreactor technology, which will enable optimization of culture conditions and control of tumor TECs development. In this review, we analyze the most popular bioreactor types in TTE and the emerging applications.

show abstract

Morphology of collagen matrices for tissue engineering (biocompatibility, biodegradation, tissue response)

Cited by 19 publications

References 9 publications

Comparative Morphological Characteristics of the Results of Implantation of Decellularized and Recellularized Porcine Skin Scaffolds

Comparative Morphological Characteristics of the Results of Implantation of Decellularized and Recellularized Porcine Skin Scaffolds

Diabetic foot syndrome. Replacement for inpatient treatment technique based on the fast track surgery

Bioreactor-Based Tumor Tissue Engineering

Contact Info

Product

Resources

About