Morphology of cystic fibrosis at 17 weeks of gestation

Cystic fibrosis: An update for clinicians. Part 2: Hepatobiliary and pancreatic manifestations

“…Pancreatic damage generally arises from ductal/glandular obstruction due to an inability to hydrate macromolecules within ductal lumens . Pancreatic damage begins in utero, with lesions found in neonates and fetuses as young as 17 weeks gestation, and this process continues into infancy and early childhood . Typical lesions consist of luminal dilation of acini by zymogen material with progressive thinning of lining epithelium .…”

“…48,49 Pancreatic damage begins in utero, with lesions found in neonates and fetuses as young as 17 weeks gestation, and this process continues into infancy and early childhood. 50,51 Typical lesions consist of luminal dilation of acini by zymogen material with progressive thinning of lining epithelium. 52 The interstitial pools of zymogen elicit an inflammatory response, with eventual loss of exocrine tissue and replacement by connective tissue.…”

Early prenatal diagnosis of cystic fibrosis by ultrasound

“…We have recently shown that trehalase assay in the amniotic fluid is a potential prenatal test for cystic fibrosis (Szabo et al 1984 and that in fetuses with cystic fibrosis slight deviations can be observed on histochemical and biochemical study as early as the 17th week of gestation (Szab6 et al 1985, Szeifert et al 1985. We have also demonstrated fetal meconium ileus by ultrasound at the 28th week of gestation by dilated intestinal lumens and unusual intensive echogenic abdominal mass which was associated with cystic fibrosis detected by low trehalase activity in amniotic fluid at the 18th week .…”

“…Abortion was induced and the female fetus weight, 170 g, was autopsied two hours after delivery. The large intestine of the fetus contained inspissated meconium closely attached to the mucosa and this caused wide dilation of the crypts and flattening of the lining epithelial cells (Szeifert et al 1985).…”

Μελέτη Της Κατάστασης Θρέψης Και Της Επίδρασης Της Στην Αναπνευστική Λειτουργία Ασθενών Με Κυστική Ίνωση

“…Κατά την εµβρυϊκή περίοδο δεν υπάρχουν µεταβολές στο πάγκρεας πριν την 17 η εβδοµάδα της κύησης [Szeifert 1985]. Σταδιακή απόφραξη των µικρών παγκρεατικών πόρων αρχίζει από την 20 η εβδοµάδα της εµβρυϊκής ζωής µε συσσώρευση ηωσινοφιλικών εκκρίσεων, η οπoία συνοδεύεται από διάταση των µικρών πόρων.…”