Morphology of hybrid doxorubicin delivery systems (dextran sulfate-coated CaCO3 vaterites) in human blood plasma

Dextran sulfate coated CaCO3 vaterites as the systems for regional administration of doxorubicin to rats

“…administration, the delivery systems enter intercellular fluid which is nearly similar to blood plasma. In our earlier works [14,16], it has been demonstrated that vaterites were gradually destroyed in plasma, resulting into increased release rate of encapsulated compounds from porous carrier. Moreover, treatment of vaterites with DexS made it possible to reach prolonged release of DOX into blood plasma.…”

“…Preparation techniques for porous carbonate vaterites, methods for coating vaterites with DexS polyanion and introducing DOX into these carriers are described in [14]. Briefly, porous vaterites (СаСО 3 cores) were prepared by co-precipitation.…”

“…Moreover, treatment of vaterites with DexS made it possible to reach prolonged release of DOX into blood plasma. Scanning electron microscopy demonstrated that structural changes in hybrid delivery systems occurring in plasma correlated with DOX release profiles [14]. After introduction of various delivery systems, DOX concentration in rat blood plasma was determined and compared with the concentration reached after administration of free DOX.…”

Subcutaneous administration of doxorubicin delivery systems based on CaCO3 vaterites coated with dextran sulfate

“…Coating of carbonate cores with dextran sulfate polyanions was performed as follows: the suspension of СаСО 3 vaterites (С=10 mg/mL) in aqueous solution of the polymer (С=5 mg/mL) was stirred for 1 h, then centrifuged; the precipitate was washed and dried [15].…”