Morphology of neural endings in the human periodontal ligament: An electron microscopic study

Lambrichts, Ivo; Creemers, J; Steenberghe, Daniël van

doi:10.1111/j.1600-0765.1992.tb01668.x

Cited by 44 publications

(37 citation statements)

References 25 publications

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“…In previous studies, cAP changes above 50% exhibited full recovery of cAPs. 27,28 Therefore, SLA-surface ITI implants and TiO 2 -blasted Astra Tech implants caused reversible inhibition of nerve conduction.…”

Section: Resultsmentioning

confidence: 97%

“…The purpose of this study was, therefore, to compare the effects of machined/turned, TiO 2 -blasted and sandblasted/acid-etched (SLA) titanium oral implant surfaces on cAPs of nerves. As natural teeth have intimate contact with intraosseous myelinated nerve fibers 9,28 and would lead to predictable and reproducible cAP values, 29 they were also used and served as a positive control to evaluate the relevance of cAP amplitudes obtained from implants.…”

Section: Introductionmentioning

confidence: 99%

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Effects of machined/turned, TiO₂‐blasted and sandblasted/acid‐etched titanium oral implant surfaces on nerve conduction: A study on isolated rat sciatic nerves

et al. 2003

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The purpose of this study was to explore the clinical relevance of the effects of machined/turned, TiO(2)-blasted and sandblasted/acid-etched titanium oral implant surfaces on nerve conduction. Isolated rat sciatic nerves were placed between two suction electrodes in a pyrex bath containing a tyrode solution. Evoked compound action potentials (cAPs) of the nerves were recorded before and after contact with the implants. The mandibular incisors of randomly selected animals were extracted and changes in cAP amplitudes were used as controls. The differences in final cAP values of Astra Tech implants and rat natural teeth were insignificant (P < 0.05), whereas the differences between other groups were significant (P < 0.05). Machined/turned-surface implants did not cause any change in cAPs. A slight decrease in cAPs was observed for TiO(2)-blasted and sandblasted/acid-etched implants, and the natural teeth. The reductions of cAPs in latter groups were not 50% after an application time of 300 min. The cAP changes of nerves contacting TiO(2)-blasted and sandblasted/acid-etched oral implants fall within physiologic limits in vitro. Machined/turned, TiO(2)-blasted, and sandblasted/acid-etched titanium implant surfaces do not lead to irreversible neurotoxic effects.

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Section: Resultsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Effects of machined/turned, TiO₂‐blasted and sandblasted/acid‐etched titanium oral implant surfaces on nerve conduction: A study on isolated rat sciatic nerves

et al. 2003

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“…There are four types of specialized nerve endings: Ruffini-like endings, that are found mainly near the root apex; coiled nerve endings, found near the mid-range of the tooth root; and spindle and expanded nerve endings, both found near the root apex. A similar description of these receptors comes from a study that used extracted teeth from humans (Lambrichts et al ., 1992).…”

Section: P Eriodontal Mechanoreceptors (Pmrs )mentioning

confidence: 99%

Reflex Control of Human Jaw Muscles

Türker

2002

Critical Reviews in Oral Biology & Medicine

139

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Introduction The main function of the masticatory muscles is to break food down into pieces small enough to be swallowed. These are strong muscles that generate very large forces across very short distances and apply themvia rigid teeth. Such large forces can easily damage the teeth and their supporting tissues, tongue, cheeks, and the joints unless they are controlled precisely and effectively. There is evidence that the masticatory forces are controlled very precisely and that these forces change from bite to bite, depending on the consistency of the bolus. However, we do not fully understand this control mechanism. Unless the details of the mechanism that controls the masticatory forces in health and disease are thoroughly understood, the diagnosis and treatment of masticatory-related dysfunctions (such as temporomandibular dysfunction) will remain at the present "symptomatic" state.The aim of this review is to discuss what is known about the control of the human masticatory system and to propose a method for standardized investigation. This review is divided into six parts. The first part discusses the activation of human jaw muscle motoneurons by the central and peripheral sources. The second part discusses the receptors that are thought to contribute to the control of human mastication. In part 3, the reflexes elicited in human subjects are discussed. In part 4, simulated chewing experiments are discussed. In part 5, recording and analyzing methods are discussed, and a new method for estimating synaptic potential in human motoneurons is introduced. Finally, in part 6, three frequently asked questions are used to discuss the issues put forward in this review.Presently, our knowledge of mastication and its control by various receptors is patchy. Most of the work in this area comes from animal species with which investigators have used widely varying reduction techniques (anesthetization, decerebration, curarization, etc.). In these preparations, when nerve pathways are the subject of the study, the nerve to be stimulated is dissected free and teased so that one or a few identified nerve fibers are stimulated. The synaptic potential that is induced by this stimulation is recorded by means of microelectrodes that are placed within the central nervous system (reviewed in Lund, 1991;Linden, 1990). It is also possible for investigators to initiate "chewing" in animal preparations, and to study the effects of various receptor systems on the development of force (Lavigne et al ., 1987;.In humans, one must establish the connections of various afferents to the motoneurons that innervate the masticatory muscles under static or dynamic conditions to begin to understand the mechanism and control of mastication. The human work is challenging, since direct recording from motoneurons is not yet possible and precise stimulation of nerves is not easily controlled. Therefore, various indirect measurements have been used for the study of synaptic potential in human subjects. In most of these studies, afferent nerves are stimul...

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“…On the other hand, the periodontal ligament is a highly specialized tissue that serves to attach the teeth to the supporting bone, and functions as a cushion that relieves mastication forces, and are innervated by several kinds of sensory nerve endings (Lambrichts, 1992). The PDL fibroblasts that are principal constituent cells in periodontal ligament play a major part of PDL functions such as support of teeth, formation and maintenance of connective fibers, and generation of PDL fibroblasts.…”

Section: Controlmentioning

confidence: 99%

The Presence of Arachidonic Acid-Activated K⁺Channel, Trek-1, in Human Periodontal Ligament Fibroblasts

Saeki

Ohara

Nishikawa

et al. 2007

Drug Metabolism Reviews

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Human periodontal ligament (PDL) fibroblasts expressed following two-pore-domain K(+) channels, TWIK-2 > TREK-1 > TWIK-1 >> TASK-1 > TRAAK > TASK-2. TREK-2 message was not detectable. We found the presence of arachidonic acid-activated and mechanical stress-sensitive K(+) channel, TREK-1, in the PDL fibroblasts by patch-clamp technique. It was also found the significant increase of intracellular concentration of arachidonic acid upon the application of cyclic stretch. Therefore, we suppose that the mechanical stretch due to the mastication activates phospholipase A(2) to release arachidonic acid (AA) from membrane, then, the released AA activates TREK-1. Thus, TREK-1 K(+) channels may play a protective role to maintain the negative membrane potential of PDL fibroblasts against the environmental stimuli.

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Morphology of neural endings in the human periodontal ligament: An electron microscopic study

Cited by 44 publications

References 25 publications

Effects of machined/turned, TiO₂‐blasted and sandblasted/acid‐etched titanium oral implant surfaces on nerve conduction: A study on isolated rat sciatic nerves

Effects of machined/turned, TiO₂‐blasted and sandblasted/acid‐etched titanium oral implant surfaces on nerve conduction: A study on isolated rat sciatic nerves

Reflex Control of Human Jaw Muscles

The Presence of Arachidonic Acid-Activated K⁺Channel, Trek-1, in Human Periodontal Ligament Fibroblasts

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Morphology of neural endings in the human periodontal ligament: An electron microscopic study

Cited by 44 publications

References 25 publications

Effects of machined/turned, TiO2‐blasted and sandblasted/acid‐etched titanium oral implant surfaces on nerve conduction: A study on isolated rat sciatic nerves

Effects of machined/turned, TiO2‐blasted and sandblasted/acid‐etched titanium oral implant surfaces on nerve conduction: A study on isolated rat sciatic nerves

Reflex Control of Human Jaw Muscles

The Presence of Arachidonic Acid-Activated K+Channel, Trek-1, in Human Periodontal Ligament Fibroblasts

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Product

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Effects of machined/turned, TiO₂‐blasted and sandblasted/acid‐etched titanium oral implant surfaces on nerve conduction: A study on isolated rat sciatic nerves

Effects of machined/turned, TiO₂‐blasted and sandblasted/acid‐etched titanium oral implant surfaces on nerve conduction: A study on isolated rat sciatic nerves

The Presence of Arachidonic Acid-Activated K⁺Channel, Trek-1, in Human Periodontal Ligament Fibroblasts