The numerous processes (superficial and deep) occurring on margins, their origins, consequences, interactions and quantifications are only very partially described and understood. The identification of the relative role of factors is sometimes completely contradictory between authors. Here, we showed the results of a long-term multidecadal and multidisciplinary study (using geophysical, geological, stratigraphic, paleontological, geomorphologic, geochemical, microbiological and numerical models) in the Western Mediterranean Sea that acts as a natural laboratory at many different scales. We showed how sediments efficiently recorded at the same time: variations of glacio-eustatic sea-level changes, variations of sediments yield and sources, and also enabled quantifying vertical movements and geodynamic worldwide events but also detailed regional mass transport, turbidites and contourites deposits. They are also an archive of paleoclimatic, palaeoceanographic and diagenetic processes.