Morphomechanics of Development

Beloussov, L. V.

doi:10.1007/978-3-319-13990-6

Cited by 33 publications

(7 citation statements)

References 150 publications

(198 reference statements)

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“…Moreover, enrichment in the subset of differentially expressed genes (DEGs) upregulated in vitro with molecules involved in diverse morphogenetic and differentiation processes ( table 1 ) indicates uncoordinated overexpression of genome regulatory programs following the loss of morphogenetic borders ( Beloussov 2015 ). Results revealed a transcriptionally heterogenous C cell population that differed transcriptionally from the in vivo system.…”

Section: Resultsmentioning

confidence: 99%

Transcription Profiling of CulturedAcropora digitiferaAdult Cells Reveals the Existence of Ancestral Genome Regulatory Modules Underlying Pluripotency and Cell Differentiation in Cnidaria

Reyes-Bermudez

Hidaka

Mikheyev

2021

Genome Biology and Evolution

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Due to their pluripotent nature and unlimited cell renewal, stem cells have been proposed as an ideal material for establishing long-term cnidarian cell cultures. However, the lack of unifying principles associated with "stemness" across the phylum complicates stem cells' identification and isolation. Here, we for the first time report gene expression profiles for cultured coral cells, focusing on regulatory gene networks underlying pluripotency and differentiation. Cultures were initiated from Acropora digitifera tip fragments, the fastest growing tissue in Acropora. Overall, in vitro transcription resembled early larvae, over-expressing orthologs of pre-metazoan and Hydra stem cell markers, and transcripts with roles in cell division, migration, and differentiation. Our results suggest the presence of pluripotent cell-types in cultures and indicate the existence of ancestral genome regulatory modules underlying pluripotency and cell differentiation in cnidaria. Cultured cells appear to be synthesizing protein, differentiating, and proliferating.

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Section: Resultsmentioning

confidence: 99%

Transcription Profiling of CulturedAcropora digitiferaAdult Cells Reveals the Existence of Ancestral Genome Regulatory Modules Underlying Pluripotency and Cell Differentiation in Cnidaria

Reyes-Bermudez

Hidaka

Mikheyev

2021

Genome Biology and Evolution

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“…Tensile patterns rather than cell positions would therefore play instructive roles in the acquisition of long-range morphological order. Importantly, they, at any given point in time, will reflect the recent developmental history of the tissue (Beloussov, 2015). Along this line, during the expansion and remodeling of the abdominal epithelia, the expression pattern of Ft modulated by Ds and fj evolves into an A/P gradient spanning whole compartments ( Fig.…”

Section: Discussionmentioning

confidence: 97%

“…The tendency of densely packed structural units to align to each other is as a rule energetically (entropically) favorable and hence widely observed in nature (Beloussov, 2015). This property is often observed in multicellular assemblies, where it has major consequences for tissue morphogenesis.…”

Section: Introductionmentioning

confidence: 99%

The Dachsous/Fat/Four-jointed pathway implements axial long-range cell orientation

Mangione¹,

Martı́n-Blanco²

2016

Preprint

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Despite a cumulative body of knowledge describing short-range cell interactions in morphogenetic processes, relatively little is known on the mechanism involved in the long-range spatial and temporal coordination of cells to build functional and structurally organized tissues. In particular, the attainment of a functionally optimized epithelia must require directional cues to instruct cell movements and cell orientations throughout the tissue field. In Drosophila, the adult epidermis of the abdominal segments is created de novo by the replacement of obsolete larval epidermal cells (LECs) by histoblasts (imaginal founder cells). As these proliferate, expand and fuse, they uniformly organize orienting on the surface along the antero-posterior axis. We found that the coordinated, axially oriented changes in shape of histoblasts respond to a dynamic, yet stereotyped redesign of the epithelial field mediated by the Dachsous/Fat/Four-jointed (Ds/Ft/Fj) pathway. The establishment and refinement of the expression gradients of the atypical cadherins Ds and Ft result in their axial polarization across cell interfaces and differential adhesiveness. We suggest that the role of Ds/Ft/Fj in long-range axially oriented planar cell alignment is a general function and that the regulation of the expression of its components would be crucial in the achievement of tissue uniformity in many other morphogenetic models or during tissue repair.3

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“…Rather soon, these effects (defined by Driesch as "embryonic regulations") were numerously confirmed and extended to the species belonging to almost all taxonomic groups of metazoans, from sponges to mammalians [31,32]. In 1901, Hans Spemann conducted an experiment on the separation of the amphibian embryo into individual cells, from which quite normal tadpoles grew (in 1935 he won the Nobel Prize for the discovery of organizing effects in embryonic development) [31]. These experimental results testify that complete sets of "causes" required for further development are contained not only within whole eggs/embryos but also in their halves, quarters, etc.…”

mentioning

confidence: 94%

“…The main result of Driesch's experiments was that fairly normal (although proportionally diminished) larvae with all of their organs properly arranged could be obtained from a single embryonic cell (blastomere) containing no more than 1⁄2 (if the two first blastomeres were separated), or even 1⁄4 (in the case of four blastomeres separation) of the entire egg's material. Rather soon, these effects (defined by Driesch as "embryonic regulations") were numerously confirmed and extended to the species belonging to almost all taxonomic groups of metazoans, from sponges to mammalians [31,32]. In 1901, Hans Spemann conducted an experiment on the separation of the amphibian embryo into individual cells, from which quite normal tadpoles grew (in 1935 he won the Nobel Prize for the discovery of organizing effects in embryonic development) [31].…”

mentioning

confidence: 99%

Symmetries in Genetic Systems and the Concept of Geno-Logical Coding

Petoukhov

Petukhova

2016

Information

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Abstract:The genetic code of amino acid sequences in proteins does not allow understanding and modeling of inherited processes such as inborn coordinated motions of living bodies, innate principles of sensory information processing, quasi-holographic properties, etc. To be able to model these phenomena, the concept of geno-logical coding, which is connected with logical functions and Boolean algebra, is put forward. The article describes basic pieces of evidence in favor of the existence of the geno-logical code, which exists in parallel with the known genetic code of amino acid sequences but which serves for transferring inherited processes along chains of generations. These pieces of evidence have been received due to the analysis of symmetries in structures of molecular-genetic systems. The analysis has revealed a close connection of the genetic system with dyadic groups of binary numbers and with other mathematical objects, which are related with dyadic groups: Walsh functions (which are algebraic characters of dyadic groups), bit-reversal permutations, logical holography, etc. These results provide a new approach for mathematical modeling of genetic structures, which uses known mathematical formalisms from technological fields of noise-immunity coding of information, binary analysis, logical holography, and digital devices of artificial intellect. Some opportunities for a development of algebraic-logical biology are opened.

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Morphomechanics of Development

Cited by 33 publications

References 150 publications

Transcription Profiling of CulturedAcropora digitiferaAdult Cells Reveals the Existence of Ancestral Genome Regulatory Modules Underlying Pluripotency and Cell Differentiation in Cnidaria

Transcription Profiling of CulturedAcropora digitiferaAdult Cells Reveals the Existence of Ancestral Genome Regulatory Modules Underlying Pluripotency and Cell Differentiation in Cnidaria

The Dachsous/Fat/Four-jointed pathway implements axial long-range cell orientation

Symmetries in Genetic Systems and the Concept of Geno-Logical Coding

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