Morphometric analysis of pediatric and nonhyperplastic prostate glands: Evidence that BPH is not a unique stromal process

Shapiro, Ellen; Hartanto, Victor; Perlman, Elizabeth J.; Tang, Rui; Wang, Bo; Lepor, Herbert

doi:10.1002/(sici)1097-0045(19971101)33:3<177::aid-pros5>3.0.co;2-g

Cited by 39 publications

(47 citation statements)

References 15 publications

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“…There have been several reports about the morphometry of the histologically normal prostate glands (Bartsch et al 1979;Deng et al 1995;Doehring et al 1996;Arenas et al 2001;Chagas et al 2002;Matsuda et al 2006;Pirus 2006). For morphological quantitation of the prostatic tissue components in normality and the diseased state, different unit names are used, including "percent area density" (Shapiro et al 1997;Aoki et al 2001;Lepor 2005), "relative areas" (percent), (Kim et al 2009), and "volumetric density"…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, a dimensionless parameter such as the stromal-to-epithelial ratio was calculated in some studies (Bartsch et al 1979;Doehring et al 1996;Shapiro et al 1997). …”

Section: Discussionmentioning

confidence: 99%

“…The data resulting from the present study also agree well with median of published results for prostate morphometric parameters of men aged 51 to 70 years (Table 5) (Deng et al 1995;Doehring et al 1996;Arenas et al 2001;Pirus 2006). Shapiro et al (1997) reported that the stromal compartment (approximately 80 %) and the stromal/epithelial ratio of the prostate (approximately 6:1) remains constant in males throughout life. In contrast, the present study provides compelling evidence that the percent volume of stroma, epithelium, lumen, and the stromal-to-epithelial ratio of the prostate significantly change in males between ages 21 and 70 years.…”

Section: Discussionmentioning

confidence: 99%

“…The stromal-to-epithelial ratio (S/E ratio) was calculated in some morphological studies (Bartsch et al 1979;Doehring et al 1996;Shapiro et al 1997). Although morphological quantitation of histological normal prostates has been reported, these studies were performed either in men under 30-years of age (Bartsch et al 1979;Shapiro et al 1997;Chagas et al 2002;Matsuda et al 2006) or over 50 years (Deng et al 1995;Doehring et al 1996;Pirus 2006). Contradictory results were obtained in these studies.…”

mentioning

confidence: 99%

“…Contradictory results were obtained in these studies. For example, Shapiro et al (1997) observed that the percent area density of the stromal component (approximately 80 %) was not age dependent. Also, that study provided evidence that the S/E ratio of the prostate remains constant in males from birth to age 40 years and equals 6:1.…”

mentioning

confidence: 99%

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Age-related histological and zinc content changes in adult nonhyperplastic prostate glands

Zaichick

2013

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To clarify age-related histological and Zn content changes in nonhyperplastic adult prostate glands, a quantitative morphometric and energy-dispersive X-ray fluorescence analyses were performed. The prostates were obtained from autopsies of 63 subjects aged 21-70 years who died mainly from trauma. It was found that histologically normal prostate tissue undergoes substantial changes throughout aging. These changes are reflected in an increase of the percent volume of the glandular lumen for the third to fifth decades, reaching a maximum for the decade 41-50 years. Over the same period, the percent volume of the stroma remains steady, but the percent volume of epithelium decreases, approximately, linearly with age. The percent volume of glandular lumen (reflects the volume of prostatic fluid) in the prostate gland of men aged 41 to 50 years is 1.5-fold higher than that in men aged 21 to 30 years, but the epithelium/lumen (prostatic fluid) ratio is approximately twofold lower. This suggests that accumulation of the prostatic fluid develops from 30 to 50 years of age. This accumulation of the prostatic fluid results in an increase of the Zn mass fraction in the prostate. In turn, when the intraprostatic Zn level exceeds a certain level by the end of the fifth decade, it begins to work as a trigger for different factors, all of which increase the proliferation of stromal cells. Deductions from these results allow possible partial explanations of both relevant prostatic aging mechanisms and the effects of dietary interventions using supplementary Zn.

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Section: Discussionmentioning

confidence: 99%

“…Additionally, a dimensionless parameter such as the stromal-to-epithelial ratio was calculated in some studies (Bartsch et al 1979;Doehring et al 1996;Shapiro et al 1997). …”

Section: Discussionmentioning

confidence: 99%